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Somatic Diversification of Immune Responses

  • Book
  • © 1998

Overview

Editors:
  1. Garnett Kelsoe

    1. Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Martin F. Flajnik

    1. Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • As knowledge from experimentation accumulates, we begin to have a somewhat clearer picture of the muation/conversion process(es).
  • This volume takes one step forward in the analysis of somatic diversification.

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 229)

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Table of contents (14 chapters)

  1. Front Matter

    Pages I-IX
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  2. The Role of Promoter-Intron Interactions in Directing Hypermutation

    • D. B. Winter, N. Sattar, P. J. Gearhart
    Pages 1-10

  3. Somatic Hypermutation of Immunoglobulin Genes is Linked to Transcription

    • U. Storb, A. Peters, E. Klotz, N. Kim, H. M. Shen, K. Kage et al.
    Pages 11-19

  4. On the Possible Role of Natural Reverse Genetics in the V Gene Loci

    • R. V. Blanden, H. S. Rothenfluth, E. J. Steele
    Pages 21-32

  5. Characteristics of Somatic Hypermutation of Human Immunoglobulin Genes

    • R. A. Insel, W. S. Varade
    Pages 33-44

  6. Antibody Diversification in the Rabbit: Historical and Contemporary Perspectives

    • D. K. Lanning, K. L. Knight
    Pages 45-57

  7. Rabbit Appendix: A Site of Development and Selection of the B Cell Repertoire

    • R. Pospisil, R. G. Mage
    Pages 59-70

  8. Affinity Maturation of the Primary Response by V Gene Diversification

    • D. M. Tarlinton, A. Light, G. J. V. Nossal, K. G. C. Smith
    Pages 71-83

  9. Lymphocyte Development and Selection in Germinal Centers

    • J. Przylepa, C. Himes, G. Kelsoe
    Pages 85-104

  10. Somatic Mutagenesis and Evolution of Memory B Cells

    • L. J. Wysocki, A. H. Liu, P. K. Jena
    Pages 105-131

  11. Repertoire Diversification of Primary vs Memory B Cell Subsets

    • N. R. Klinman
    Pages 133-148

  12. Plasticity Under Somatic Mutation in Antigen Receptors

    • T. B. Kepler, S. Bartl
    Pages 149-162

  13. Theoretical Limits to Massive Receptor Editing in Immature B Cells

    • D. Nemazee
    Pages 163-171

  14. Clone: A Monte-Carlo Computer Simulation of B Cell Clonal Expansion, Somatic Mutation, and Antigen-Driven Selection

    • M. J. Shlomchik, P. Watts, M. G. Weigert, S. Litwin
    Pages 173-197

  15. Somatic Mutation in Ectothermic Vertebrates: Musings on Selection and Origins

    • L. Du Pasquier, M. Wilson, A. S. Greenberg, M. F. Flajnik
    Pages 199-216

  16. Back Matter

    Pages 217-225
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Keywords

About this book

Discovery of the mechanism for V(D)J hypermutation remains a basic goal of immunology despite the best efforts of many labo­ ratories. The existence of catalyzed, site-specific mutation and its exploitation for the somatic evolution of lymphocytes are re­ markable adaptations, yet since the discovery of hypermutation in 1970 (see cover), much hard work has generated little. Indeed, our knowledge of what is probably absolutely required for the mutator's action can be succinctly expressed: /g gene enhancers. Table 1 of Winter et a!.'s chapter puts into a historical perspec­ tive how our notions of the mutator have changed over the years. Despite these modest gains, most of us feel that this is the best of times. Our work has not only shown us what the mutator is not, it has also, like an artist's preliminary sketch, defined the questions and experiments we must face without diminishing the potential for new biology. In short, it is great fun to toil against a significant and enigmatic problem.

Editors and Affiliations

  • Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, USA

    Garnett Kelsoe

  • Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, USA

    Martin F. Flajnik

Bibliographic Information

  • Book Title: Somatic Diversification of Immune Responses

  • Editors: Garnett Kelsoe, Martin F. Flajnik

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-71984-4

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 1998

  • Softcover ISBN: 978-3-642-71986-8Published: 10 December 2011

  • eBook ISBN: 978-3-642-71984-4Published: 06 December 2012

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: X, 221

  • Topics: Immunology, Cell Biology, Molecular Medicine, Microbiology, Animal Physiology

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