Differentiation of B Lymphocytes

1. Front Matter

   Pages I-IX

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2. Stromal Cell and Factor-Dependent B Lymphopoiesis in Culture

   • P. W. Kincade, P. L. Witte, K. S. Landreth

   Pages 1-21

3. Long-Term Murine Hemopoietic Cultures as Model Systems for Analysis of B Lymphocyte Differentiation

   • K. Dorshkind, O. N. Witte

   Pages 23-41

4. Peyer’s Patches and the Early Development of B Lymphocytes

   • J. D. Reynolds

   Pages 43-56

5. B-Cell Commitment and Diversification in the Bursa of Fabricius

   • J. R. L. Pink, O. Lassila

   Pages 57-64

6. Differentiation of Murine B-Cell Progenitors in Agar Culture: Determination of the Developmental Potential of Clonable Pre-B Cells

   • H. Sauter, C. J. Paige

   Pages 65-74

7. Expression of the Immunoglobulin Heavy-Chain Variable Gene Repertoire

   • B. A. Malynn, J. E. Berman, G. D. Yancopoulos, C. A. Bona, F. W. Alt

   Pages 75-94

8. Programmed Development of the Antibody Repertoire

   • R. M. Perlmutter

   Pages 95-109

9. Questioning the Role of the Embryonic Bursa in the Molecular Differentiation of B Lymphocytes

   • J.-C. Weill, M. Leibowitch, C.-A. Reynaud

   Pages 111-124

10. Immunoglobulin Gene Rearrangements in Pre-B Cells

    • P. D. Burrows, H. Kubagawa

    Pages 125-138

11. Cloning of Murine B-Lymphocyte Differentiation Stage-Specific Genes

    • N. Sakaguchi, C. N. Berger, F. Melchers

    Pages 139-148

12. Back Matter

    Pages 149-150

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Rapid progress continues to be made in understanding the molecular and cellular events that comprise B-Iymphocyte differentiation. This is due in part to the high level of inter­ est shown by many investigators from diverse disciplines, who find this subject suitable for addressing some of the fundamental issues of immunobiology. B-cell developmen­ tal models are being extensively used to investigate cell-cell interactions, molecular mediators of differentiation and proliferation, differential onset of gene programs, and gene rearrangement and expression, as well as the generation of the immune response itself. Not surprisingly, increased understanding of B-cell differentiation sometimes results from the application of new techniques that permit greater insight into the cells comprising the system and the genetic mechanisms by which these cells express their differentiative potential. However, experimental strategies based upon the novel application of established technologies have also led to the clarification of many issues, as well as to the discov­ ery of previously unrecognized problems. One problem, well recognized by those active in the field, is how to keep up with significant developments as they appear. The purpose of this book, part of a series devoted to analysing current issues in biology, is to help overcome this problem. No attempt at comprehensive cov­ erage of all of the issues has been made. Rather, a more thorough analysis of a few topics is presented.

• gene
• immune response
• immunobiology
• lymphocytes
• proliferation

• Basel Institute for Immunology, Basel, Switzerland

  Christopher J. Paige, Roland H. Gisler

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