Mesenchymal-Epithelial Interactions in Neural Development

1. Front Matter

   Pages I-XIV

   PDF

2. Molecular and Cell Biology of the Extracellular Matrix

   1. Front Matter

      Pages 1-1

      PDF

   2. Components of the Extracellular Matrix (Collagens, Elastin, Glyco-Proteins and Proteoglycans)

      • D. Schuppan, E. G. Hahn

      Pages 3-29

   3. Structure, Expression and Function of Mouse Laminin

      • Y. Yamada, A. Albini, I. Ebihara, J. Graf, S. Kato, P. Killen et al.

      Pages 31-43

   4. Distribution of ECM Components in Early Embryos

      • R. Herken, Ch. Brandes, M. Fussek

      Pages 45-52

   5. Production and Formation of the Basal Lamina

      • H.-J. Merker

      Pages 53-64

   6. Cell Surface Extracellular Matrix Glycoproteins Proteoglycans in Nervous Tissue

      • R. U. Margolis, J. A. Ripellino, R. K. Margolis

      Pages 65-76

   7. Hyaluronectin and Hyaluronic Acid During the Development of Rat Brain Cortex

      • Annie Delpech, Bertrand Delpech, Nicole Girard, Philippe Bertrand, Claude Chauzy

      Pages 77-87

3. Mesenchymal-Epithelial Interaction in the Morphogenesis of Epithelial Organs

   1. Front Matter

      Pages 89-89

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   2. Control of Epithelial Polarity and Induction in the Early Chick Embryo

      • Claudio D. Stern

      Pages 91-100

   3. Cell Interactions During Kidney Development

      • P. Ekblom, E. Aufderheide, G. Klein, A. Kurz, A. Weller

      Pages 101-110

   4. Cell-Matrix Interaction in the Differentiation of the Intestinal Epithelium

      • Ursula Hahn, D. Schuppan, E. G. Hahn, H.-J. Merker, E.-O. Riecken

      Pages 111-117

   5. Connective Tissue and Ductular Metaplasia of Hepatocytes

      • R. Schulz, D. Schuppan, E. G. Hahn

      Pages 119-125

   6. Effects of an Inhibitor of Proteoglycan Biosynthesis on Neuron-Induced Schwann Cell Proliferation and Basal Lamina Formation By Schwann Cells

      • N. Ratner, C. Eldridge, R. Bunge, L. Glaser

      Pages 127-139

   7. Mechanisms of Morphogenetic Specification in Skull Development

      • Peter Thorogood

      Pages 141-152

   8. Influence of the Notochord on the Morphogenesis of the Neural Tube

      • H. W. M. van Straaten, J. Drukker

      Pages 153-162

   9. Is There a Specific Interaction Between Donor Embryonic Entoderm (Chick or Quail) and Host Embryonic Mesoderm (Chick)?

      • E. Wiertz-Hoessels, J. Drukker

      Pages 163-170

   10. Influences of Meningeal Cells on the Development of the Brain

       • J. Sievers, D. Hartmann, S. Gude, F. W. Pehlemann, M. Berry

       Pages 171-188

4. Cell Proliferation, Growth and Differentiation

   1. Front Matter

      Pages 189-189

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   2. Fibroblast Growth Factor: Molecular and Biological Properties

      • D. Gospodarowicz, G. Neufeld

      Pages 191-221

This book is based on the NATO Advanced Research Workshop on "Mesenchymal-Epithelial Interactions in Neural Development" which was held in Berlin during March 1986. The idea that it may be the time for this workshop arose from a discussion among the organizers who met at a conference in Innsbruck. During the twenties, Spemann demonstrated that, in vertebrates, the formation of neuroepithelium depends on the induction by specific mesodermal derivatives. This was about the first time that mesenchymal-epithelial interactions had been recognized as an important mechanism in the development of an epithelial organ. Since then two things had become clear: 1) The identity and role of molecules, elaborated at mesenchymal-neuroepithelial interfaces had been partially elucidated in spinal cord and peripheral nerve ontogeny but, until recently, had been ignored in studies on the development of the brain. 2) In many-non-neural epithelia, the surrounding mesenchyme regulates such fundamental developmental steps as, for example, cell proliferation, morphogenesis and cell differentia­ tion, and there is no reason to exclude similar influences and interactions from brain development. It seemed to us that the importance and implications of many of these findings had not been appreciated by many developmental neurobiologists and that an attempt should be made to initiate discussions and exchange of ideas among different groups of scientists involved in extracellular matrix (ECM) research. This turned out to be a formidable task because of the great diversity of disciplines contributing findings to this active field.

• brain
• cell
• influence
• morphogenesis
• spinal cord

• Berlin Institute for Advanced Study, Zentrum Anatomie, Göttingen, Germany

  Joachim R. Wolff

• Universität Göttingen, Zentrum Anatomie, Göttingen, Germany

  Joachim R. Wolff

• Anatomiches Institut, Universität Kiel, Kiel, Germany

  Jobst Sievers

• Department of Anatomy, Guy’s Hospital Medical School, London, England

  Martin Berry

Policies and ethics