Calcium in Drug Actions

1. Front Matter

   Pages I-XXVI

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2. The Multiple Physiological Roles of Calcium: Possible Sites for Pharmacological Intervention

   1. The Multiple Physiological Roles of Calcium: Possible Sites for Pharmacological Intervention

      • A. W. Cuthbert

      Pages 1-6

3. Calcium Receptors and Calcium Metabolism

   1. Front Matter

      Pages 7-7

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   2. Chemical Factors Determining the Affinity of a Receptor for Calcium

      • B. A. Levine, R. J. P. Williams

      Pages 9-29

   3. Troponin C and Calmodulin as Calcium Receptors: Mode of Action and Sensitivity to Drugs

      • S. Ebashi, Y. Ogawa

      Pages 31-56

   4. Ligand-Binding Sites on Calmodulin

      • H. J. Vogel

      Pages 57-87

   5. Calcium Channels as Drug Receptors

      • M. Schramm, R. Towart

      Pages 89-114

   6. The Chemistry of Calcium Channel Agonists and Antagonists

      • D. J. Triggle

      Pages 115-133

   7. The Apamin-Sensitive Ca2+-Dependent K+ Channel: Molecular Properties, Differentiation, Involvement in Muscle Disease, and Endogeneous Ligands in Mammalian Brain

      • M. Lazdunski, G. Romey, H. Schmid-Antomarchi, J. F. Renaud, C. Mourre, M. Hugues et al.

      Pages 135-145

   8. Drug Effects on Plasma Membrane Calcium Transport

      • F. F. Vincenzi, T. R. Hinds

      Pages 147-162

   9. Development of Inhibitors of Sodium, Calcium Exchange

      • G. J. Kaczorowski, M. L. Garcia, V. F. King, R. S. Slaughter

      Pages 163-183

   10. The Effect of Ruthenium Red and Other Agents on Mitochondrial Calcium Metabolism

       • M. Crompton

       Pages 185-198

   11. Pharmacology of Calcium Uptake and Release from the Sarcoplasmic Reticulum: Sensitivity to Methylxanthines and Ryanodine

       • R. A. Chapman, J. Tunstall

       Pages 199-216

   12. Effect of Lithium in Stimulus — Response Coupling

       • I. Schulz

       Pages 217-240

   13. Phorbol Esters and Protein Kinase C

       • H. Nagamoto, U. Kikkawa, Y. Nishizuka

       Pages 241-252

4. Calcium and Physiological Function

   1. Front Matter

      Pages 253-253

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   2. Drugs Acting on Calcium Channels

      • T. Narahashi

      Pages 255-274

   3. Calcium and Synaptic Function

      • M. P. Blaustein

      Pages 275-304

   4. Some New Questions Concerning the Role of Ca2+ in Exocytosis

      • S. Cockcroft, B. D. Gomperts

      Pages 305-338

   5. Exo-Endocytosis: Mechanisms of Drug and Toxin Action

      • J. Meldolesi, T. Pozzan, B. Ceccarelli

      Pages 339-359

The Editorial Board and the Publishers of the Handbook of Experimental Pharmacology wish to express their profound grief at the untimely death of Professor Peter Baker. Aware of his international recognition as an expert on the ubiquitous role of calcium in physiological processes and their pharma­ cological control, the Board was gratified when Professor Baker accepted its invitation to edit a new Handbook volume on "Calcium in Drug Actions". He went about this task with his usual energy and effectiveness so that, in the few months before his unexpected death, Professor Baker had mustered his distinguished contributors, got them to provide their manuscripts, and seen almost the entire material into the press. This achievement is all the more remarkable when one bears in mind the extraordinary number of his other commitments during the same time; they are mentioned in Sir Alan Hodgkin's preface to this volume. With so many other professional and personal responsibilities upon him, the Board of the Handbook wishes to record its grateful appreciation for the admirable way in which Professor Baker took on and carried out the additional work of bringing this fine book into existence; and the Board wishes it to be dedicated to the memory of Professor Peter Frederick Baker. The Editorial Board: G. V. R. BORN, P. CUATRECASAS, H. HERKEN, A.

• ATP
• ATPase
• Calcium
• bone
• lead
• metabolism
• proteins
• smooth muscle

• Department of Physiology King’s College, University of London, London, Great Britain

  Peter F. Baker

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