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Blood Cells, Rheology, and Aging

  • Conference proceedings
  • © 1988

Overview

Editors:
  1. Dieter Platt

    1. Instituts für Gerontologie, Universität Erlangen-Nürnberg, Nürnberg, Germany
      2. Medizinischen Klinik, Klinikum Nürnberg, Nürnberg, Germany

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Table of contents (20 papers)

  1. Front Matter

    Pages I-XII
    Download chapter PDF

  2. Hemopoiesis as a Model for the “Biological Clock”

    • D. Danon, A. Knyszynski, L. Hayflick
    Pages 1-12

  3. Red Cell Membrane Skeleton: Assembly and Function

    • J. Palek
    Pages 13-15

  4. Red Cell Membrane Lipids and Aging

    • H. Heckers, D. Platt
    Pages 16-28

  5. Red Cell Membrane Proteins, Glycoproteins, and Aging

    • D. Platt, W. Rieck
    Pages 29-41

  6. The Effect of Host and Cell Age on the Rat Erythrocyte: Biochemical Aspects

    • D. Gershon, G. A. Glass, H. Gershon
    Pages 42-50

  7. The Effect of Host and Cell Age on the Rat and Human Erythrocyte: Cellular and Immunologic Aspects

    • H. Gershon, G. Glass, D. Gershon
    Pages 51-61

  8. Removal of Old and Abnormal Red Blood Cells from Circulation: Mechanical and Immunologic Mechanisms

    • D. Drenckhahn
    Pages 62-72

  9. Mechanism for Elimination of Senescent Red Blood Cells from Circulation

    • N. Khansari
    Pages 77-89

  10. The Influence of Piracetam on the Age-Dependent Rate of Phagocytosis (in the Isolated Perfused Rat Liver)

    • T. Vömel, D. Platt
    Pages 90-98

  11. Changes in Human Red Cell Mechanics During In Vivo Aging: Possible Influence on Removal of Senescent Cells

    • G. B. Nash, O. Linderkamp, C. Pfafferoth, H. J. Meiselman
    Pages 99-112

  12. Age-Related Physiologic and Molecular Changes in the Thymus

    • T. Makinodan, N. Kinohara, M.-P. Chang
    Pages 113-121

  13. The Cellular Basis and Clinical Significance of Immune Senescence

    • M. E. Weksler
    Pages 122-126

  14. Regulation of the Immune and Nonimmune Aging Process by the Major Histocompatibility Complex

    • R. L. Walford
    Pages 127-138

  15. Age-Related Morphologic Changes in Lymphocytes

    • E. Beregi
    Pages 139-149

  16. Receptor and Postreceptor Changes During Lymphocyte Aging

    • G. S. Roth
    Pages 150-157

  17. Mechanism of Red Cell Aggregation

    • D. E. Brooks
    Pages 158-162

  18. Fluidity of Blood of Elderly Patients and Rheologic Therapies

    • H. Kiesewetter, F. Jung, N. Körber, H. P. Nüttgens, S. Wolf, R. Schneider et al.
    Pages 163-176

  19. Hemostasis, Microcirculation, and Thrombophilia in the Aged

    • P. de Nicola, G. Casale
    Pages 177-193

  20. Influence of Age, Sex, and Blood Group on Blood Coagulation

    • Th. B. Wahlberg
    Pages 194-200
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Keywords

About this book

In the third Erlangen-Nuremberg symposium on experimental geronto­ logy we discussed the effect of aging on blood cells and rheology. Most studies with red cells have been performed on humans, rats, and rabbits. All these erythrocytes have no nucleus; the cells are therefore a model in which new synthesis of proteins is impossible. All the processes are age dependent except for exchange with the plasma. Investigations of red cells have attracted attention because of the latter's availability in large quantities from biochemists, physiologists, immunologists, and micro­ scopists. We now have a relative abundance of data on the biochemical and immunologic composition as well as on the ultrastructure of the cells. The second topic under discussion at the symposium was the immune system and cell receptors. One of the most apparent features of aging of the organism is progressive dysregulation of the immune system. As a result, the incidence of infection, cancer, and autoimmune and immune complex diseases increases. While we have a lot of new data on the function and differentiation of lymphoid cells, we have little informa­ tion on lymphocyte receptors during the aging process. Rheologic studies reflect changes in red cell deformability and blood coagulation. The erythrocyte deformability influences blood flow in all parts of the circulation. The fluidity of the red cell membranes controls whole blood viscosity. During aging, there are significant alterations in blood coagulation and hemostasis. One of the best known modifications of blood co­ agulation is a typical thrombophilic tendency with aging.

Editors and Affiliations

  • Instituts für Gerontologie, Universität Erlangen-Nürnberg, Nürnberg, Germany

    Dieter Platt

  • 2. Medizinischen Klinik, Klinikum Nürnberg, Nürnberg, Germany

    Dieter Platt

Bibliographic Information

  • Book Title: Blood Cells, Rheology, and Aging

  • Editors: Dieter Platt

  • DOI: https://doi.org/10.1007/978-3-642-71790-1

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1988

  • Softcover ISBN: 978-3-642-71792-5Due: 29 December 2011

  • eBook ISBN: 978-3-642-71790-1Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XII, 217

  • Topics: Solid Mechanics, Hematology, Allergology, Immunology

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