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Arenaviruses

Genes, Proteins, and Expression

  • Conference proceedings
  • © 1987

Overview

Editors:
  1. Michael B. A. Oldstone

    1. Department of Immunology, Scripps Clinic and Research Foundation, La Jolla, USA

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Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 133)

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Table of contents (7 papers)

  1. Front Matter

    Pages i-vii
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  2. The Arenaviruses — An Introduction

    • M. B. A. Oldstone
    Pages 1-4

  3. Arenavirus Gene Structure and Organization

    • D. H. L. Bishop, D. D. Auperin
    Pages 5-17

  4. Sequence Comparison Among Arenaviruses

    • P. J. Southern, D. H. L. Bishop
    Pages 19-39

  5. Protein Structure and Expression Among Arenaviruses

    • M. J. Buchmeier, B. S. Parekh
    Pages 41-57

  6. Mapping Arenavirus Genes Causing Virulence

    • Y. Riviere
    Pages 59-65

  7. State of Viral Genome and Proteins During Persistent Lymphocytic Choriomeningitis Virus Infection

    • S. J. Francis, P. J. Southern, A. Valsamakis, M. B. A. Oldstone
    Pages 67-88

  8. Pathology and Pathogenesis of Arenavirus Infections

    • D. H. Walker, F. A. Murphy
    Pages 89-113

  9. Back Matter

    Pages 115-116
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Keywords

About this book

M. B. A. OLDSTONE Viruses are generally studied either because they cause significant human, animal or plant disease or for their utility as materials to probe a basic phenomenon in biology, chemistry, genetics or molecular biology. Arenaviruses are unusually interesting in that they occupy both of these categories. Arenaviruses cause severe human diseases known primarily as the hemor­ rhagic fevers occurring in South and Latin America (Bolivia: Machupo virus and Argentina: Junin virus) and in Africa (Lassa virus). Because such viruses produce profound disability and may kill the persons they infect, they are a source of economic hardship in the countries where they are prevalent. Further, they provide new problems for health care personnel owing to the narrowing of the world as visitors from many countries increasingly travel to and from these endemic areas. In addition, lymphocytic choriomeningitis virus (LCMV) can infect humans worldwide, although the illness is most often less disabling than those elicited by other arenaviruses. Yet LCMV is likely of greater concern to non-arena-virologists and experimentalists using tissue culture or animals, i. e. , workers in molecular biology, cancer research, virology, immunobiology, etc. , because normal appearing cultured cells or tissues and animals used for research may be persistently infected with LCMV without manifesting clinical disease or cytopathology and transmit that infection to laboratory workers (reviewed OWSTONE and PETERS 1978). For example, HINMAN et al.

Editors and Affiliations

  • Department of Immunology, Scripps Clinic and Research Foundation, La Jolla, USA

    Michael B. A. Oldstone

Bibliographic Information

  • Book Title: Arenaviruses

  • Book Subtitle: Genes, Proteins, and Expression

  • Editors: Michael B. A. Oldstone

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-71683-6

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 1987

  • Softcover ISBN: 978-3-642-71685-0Published: 17 November 2011

  • eBook ISBN: 978-3-642-71683-6Published: 06 December 2012

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: VII, 116

  • Topics: Medical Microbiology, Allergology, Immunology, Virology

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