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Mouse Liver Tumors

Relevance to Human Cancer Risk Symposium of the European Society ofToxicology Held in Rome, February 2–5, 1986

  • Conference proceedings
  • © 1987

Overview

Editors:
  1. Philip L. Chambers

    1. Department of Pharmacology and Therapeutics, Trinity College, University of Dublin, Dublin 2, Ireland

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  2. Dietrich Henschler

    1. Institut für Toxikologie und Pharmakologie, der Universität Würzburg, Würzburg, Germany

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  3. Franz Oesch

    1. Institut für Toxikologie, der Universität Mainz, Mainz, Germany

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Part of the book series: Archives of Toxicology (TOXICOLOGY, volume 10)

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Table of contents (25 papers)

  1. Front Matter

    Pages i-vi
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  2. Introduction

    1. Front Matter

      Pages 1-1
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    2. The Mouse in Safety Evaluation

      • J. Doull
      Pages 3-9

    3. Liver Lesions in B6C3F1 Mice: The National Toxicology Program, Experience and Position

      • R. R. Maronpot, J. K. Haseman, G. A. Boorman, S. E. Eustis, G. N. Rao, J. E. Huff
      Pages 10-26

  3. Biology and Functional Properties of Mouse Liver Nodules

    1. Front Matter

      Pages 27-27
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    2. Invasiveness, Metastasis, and Transplantability of Mouse Liver Nodules

      • S. D. Vesselinovitch
      Pages 29-42

    3. Xenobiotic-Induced Peroxisome Proliferation: Role of Tissue Specificity and Species Differences in Response in the Evaluation of the Implications for Human Health

      • J. K. Reddy, M. S. Rao
      Pages 43-53

    4. The Role of Necrosis in Hepatocellular Proliferation and Liver Tumors

      • P. M. Newberne, P. Punyarit, J. de Camargo, V. Suphakarn
      Pages 54-67

    5. Biological Markers Characterizing the Development of Preneoplastic and Neoplastic Lesions in Rodent Liver

      • D. G. Beer, H. C. Pitot
      Pages 68-80

    6. Relationship Among Histochemically Distinguishable Early Lesions in Multistep-Multistage Hepatocarcinogenesis

      • E. Scherer
      Pages 81-94

    7. The Histopathology and Biochemistry of Phenobarbitone-Induced Liver Nodules in C3H Mice

      • S. D. Gangolli, B. G. Lake, J. G. Evans
      Pages 95-107

  4. Molecular Basis

    1. Front Matter

      Pages 109-109
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    2. Species Differences in Enzymes Controlling Reactive Epoxides

      • H. R. Glatt, F. Oesch
      Pages 111-124

    3. Species Differences of Glucuronidation and Sulfation in Relation to Hepatocarcinogenesis

      • K. W. Bock, G. Schirmer
      Pages 125-135

    4. Glutathione S-Transferase Subunits in the Mouse and Their Catalytic Activities Towards Reactive Electrophiles

      • J. D. Hayes, R. E. Coulthwaite, P. K. Stockman, A. J. Hussey, T. J. Mantle, C. R. Wolf
      Pages 136-146

    5. Species Differences in Biotransformation of and Peroxisome Proliferation Due to Trichloroethylene

      • C. R. Elcombe, I. S. Pratt, T. Green
      Pages 147-147

    6. The Distribution of Carcinogen Metabolizing Enzymes in the Mouse Liver: Comparison of Parenchymal and Non-Parenchymal Cell Populations

      • P. Steinberg, W. M. Lafranconi, F. Oesch
      Pages 148-156

    7. Investigations on the Mechanism of Liver Tumour Induction by Peroxisome Proliferators

      • P. Bentley, F. Bieri, F. Mitchell, F. Waechter, W. Stäubli
      Pages 157-161

    8. DNA Damage and Repair in Mouse Liver

      • J. A. Swenberg, T. R. Fennell
      Pages 162-171

    9. Individual Differences in DNA Repair Capacities in Man

      • F. Oesch, W. Aulmann, K. L. Platt, G. Doerjer
      Pages 172-179
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Keywords

About this book

Peroxisome proliferation in the liver parenchymal cells is frequently observed in rats and mice exposed to certain xenobiotic compounds. Hepatic peroxisome pro­ liferation was first noted nearly twenty years ago in the livers of rats treated with the hypolipidemic drug clofibrate (Hess et aI. , 1965; Svoboda and Azarnoff, 1966). Subsequently, several structurally unrelated hypolipidemic compounds were found to induce marked hepatomegaly and hepatic peroxisome proliferation in rats and mice, which led to the suggestion of a possible relationship between peroxisome proliferation and lipid metabolism (Reddy and Krishnakantha, 1975) as well as to the identification of a peroxisomal fatty acid f3-oxidation enzyme sys­ tem in the rat liver (Lazarow and DeDuve 1976). A second major class of per ox i­ some proliferators was identified nearly ten years ago, with the discovery that the dietary administration of a widely used phthalate-ester plasticizer di(2-ethylhex­ yl)phthalate (DEHP) to rats, results in the induction of peroxisomal enzymes in liver (Reddy et aL 1976a). Hypolipidemic drugs and phthalate-ester plasticizers constitute two major and important categories of chemicals with profound peroxisome proliferative property (Reddy et aL 1982; Reddy and Lalwani 1983). These two classes of xenobiotics now have important roles. First, the hypolipi­ demic drugs are increasingly used in the control of hyperlipidemia, a major risk factor for developing coronary heart disease.

Editors and Affiliations

  • Department of Pharmacology and Therapeutics, Trinity College, University of Dublin, Dublin 2, Ireland

    Philip L. Chambers

  • Institut für Toxikologie und Pharmakologie, der Universität Würzburg, Würzburg, Germany

    Dietrich Henschler

  • Institut für Toxikologie, der Universität Mainz, Mainz, Germany

    Franz Oesch

Bibliographic Information

  • Book Title: Mouse Liver Tumors

  • Book Subtitle: Relevance to Human Cancer Risk Symposium of the European Society ofToxicology Held in Rome, February 2–5, 1986

  • Editors: Philip L. Chambers, Dietrich Henschler, Franz Oesch

  • Series Title: Archives of Toxicology

  • DOI: https://doi.org/10.1007/978-3-642-71617-1

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1987

  • Softcover ISBN: 978-3-540-17124-9Due: 01 January 1987

  • eBook ISBN: 978-3-642-71617-1Published: 06 December 2012

  • Series ISSN: 0171-9750

  • Edition Number: 1

  • Number of Pages: VI

  • Number of Illustrations: 18 b/w illustrations

  • Topics: Pharmacology/Toxicology, Oncology, Pharmacy

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