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Peptides as Immunogens

  • Conference proceedings
  • © 1986

Overview

Editors:
  1. Hilary Koprowski

    1. The Wistar Institute, Philadelphia, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Fritz Melchers

    1. Institute for Immunology, Basel, Switzerland

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 130)

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Table of contents (7 papers)

  1. Front Matter

    Pages I-X
    Download chapter PDF

  2. Peptides as Immunogens: Prospects for Synthetic Vaccines

    • R. Arnon
    Pages 1-12

  3. Molecular Features of Class II MHC-Restricted T-Cell Recognition of Protein and Peptide Antigens: The Importance of Amphipathic Structures

    • J. A. Berzofsky, J. Cornette, H. Margalit, I. Berkower, K. Cease, C. DeLisi
    Pages 13-24

  4. Peptides as Probes to Study Molecular Mimicry and Virus-Induced Autoimmunity

    • T. Dyrberg, M. B. A. Oldstone
    Pages 25-37

  5. The Use of Peptides in Studying Mechanisms of Immune Tolerance

    • G. M. Gammon, E. E. Sercarz
    Pages 39-50

  6. Immune Response to Synthetic Herpes Simplex Virus Peptides:The Feasibility of a Synthetic Vaccine

    • E. Heber-Katz, B. Dietzschold
    Pages 51-64

  7. Antigen Presentation by B Lymphocytes: A Critical Step in T-B Collaboration

    • A. Lanzavecchia
    Pages 65-78

  8. The Value of Synthetic Peptides as Vaccines for Eliciting T-Cell Immunity

    • R. H. Schwartz
    Pages 79-85
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Keywords

About this book

The humoral response of the immune system to a foreign antigen usually requires the recognition of two antigenic determinants. The one, called the carrier, is recognized by T-Iymphocytes, the other, called the hapten, by B-Iympho­ cytes. As a consequence, T - and B-Iymphocytes proliferate, B-Iymphocytes produce hapten-specific antibodies, and the system develops memory to the antigens. It was long thought that antigens would form a bridge to mediate the cooperation of T - and B-Iymphocytes. However, it now appears that antigens are broken down to fragments which then act as carrier determinants for T -lymphocytes. The cells which originally process antigen are called an­ tigen-presenting cells. They have phagocytic properties. They can take up and degrade antigens, in the case of pro­ teins to peptides. The peptides of protein antigens reappear on the surface of the antigen-presenting cells, where they must become associated with membrane proteins encoded by genes of the major histocompatibility complex (MHC) in order to be recognized by T-Iymphocytes. To activate helper T-Iym­ phocytes which cooperate in antibody responses, MHC class II molecules have to be expressed on the surface of the antigen-presenting cells. Once T -lymphocytes have be­ come activated, they are ready to cooperate with B cells.

Editors and Affiliations

  • The Wistar Institute, Philadelphia, USA

    Hilary Koprowski

  • Institute for Immunology, Basel, Switzerland

    Fritz Melchers

Bibliographic Information

  • Book Title: Peptides as Immunogens

  • Editors: Hilary Koprowski, Fritz Melchers

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-71440-5

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 1986

  • Softcover ISBN: 978-3-642-71442-9Published: 06 December 2011

  • eBook ISBN: 978-3-642-71440-5Published: 06 December 2012

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: X, 86

  • Topics: Medical Microbiology, Allergology, Immunology

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