Host-Parasite Relationships and the Yersinia Model

1. Front Matter

   Pages I-XI

   PDF

2. Virulence Factors and Their Genetic Control

   1. Front Matter

      Pages 1-2

      PDF

   2. Microorganisms

      • Akira Wake, Herbert R. Morgan

      Pages 3-8

   3. Host-Parasite Relationship

      • Akira Wake, Herbert R. Morgan

      Pages 9-11

   4. Localization of Virulence Determinants

      • Akira Wake, Herbert R. Morgan

      Pages 12-15

   5. Superficial Infection With or Without Toxinogenesis

      • Akira Wake, Herbert R. Morgan

      Pages 16-34

   6. Exudative (Partially Invasive) Infections

      • Akira Wake, Herbert R. Morgan

      Pages 35-49

   7. Invasive (Penetrating) Infections (Except Yersiniosis)

      • Akira Wake, Herbert R. Morgan

      Pages 50-75

   8. Summary

      • Akira Wake, Herbert R. Morgan

      Pages 76-81

3. Defense Mechanisms of Host Against Infection

   1. Front Matter

      Pages 79-80

      PDF

   2. Recognition by the Immune System

      • Akira Wake, Herbert R. Morgan

      Pages 82-85

   3. The Mechanisms for Maintenance of Self-Integrity

      • Akira Wake, Herbert R. Morgan

      Pages 86-89

   4. Superficial Defense

      • Akira Wake, Herbert R. Morgan

      Pages 90-95

   5. The Role of Body Temperature: Fever and Reduced Iron

      • Akira Wake, Herbert R. Morgan

      Pages 96-105

   6. The Defensive Role of Normal Microbial Flora

      • Akira Wake, Herbert R. Morgan

      Pages 106-114

   7. The Nonspecific Humoral Components

      • Akira Wake, Herbert R. Morgan

      Pages 115-130

   8. Specific Humoral Components: Immunoglobulins

      • Akira Wake, Herbert R. Morgan

      Pages 131-137

   9. Genesis and Distribution of Cellular Components with Defensive Functions

      • Akira Wake, Herbert R. Morgan

      Pages 138-146

   10. Extracellular and Intracellular Destruction of Microorganisms

       • Akira Wake, Herbert R. Morgan

       Pages 147-158

   11. Inflammation, as a Defense Mechanism

       • Akira Wake, Herbert R. Morgan

       Pages 159-163

During the past few decades we have witnessed an era of remarkable growth in the field of molecular biology. In 1950 very little was known of the chemical constitution of biological systems, the manner in which information was transmitted from one organism to another, or the extent to which the chemical basis of life is unified. The picture today is dramatically different. We have an almost bewildering variety of information detailing many different aspects oflife at the molecular level. These great advances have brought with them some breath-taking insights into the molecular mechanisms used by nature for replicating, distributing and modifying biological information. We have learned a great deal about the chemical and physical nature of the macro­ molecular nucleic acids and proteins, and the manner in which carbohydrates, lipids and smaller molecules work together to provide the molecular setting of living systems. It might be said that these few decades have replaced a near vacuum of informa­ tion with a very large surplus. It is in the context of this flood of information that this series of monographs on molecular biology has been organized. The idea is to bring together in one place, between the covers of one book, a concise assessment of the state of the subject in a well-defined field. This will enable the reader to get a sense of historical perspective­ what is known about the field today - and a description of the frontiers of research where our knowledge is increasing steadily.

• biology
• molecular biology
• molecular mechanisms
• nucleic acid
• parasite
• proteins
• yersinia

• Department of Bacteriology, National Institute of Health, Shinagawa-ku, Tokyo 141, Japan

  Akira Wake

• School of Medicine and Dentistry, University of Rochester, Rochester, USA

  Herbert R. Morgan

Policies and ethics