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Clinical Pharmacology in Psychiatry

Selectivity in Psychotropic Drug Action — Promises or Problems?

  • Conference proceedings
  • © 1987

Overview

Editors:
  1. Svein G. Dahl

    1. Department of Pharmacology, Institute of Medical Biology, University of Tromsø School of Medicine, Tromsø, Norway

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  2. Lars F. Gram

    1. Department of Clinical Pharmacology, School of Medicine, Odense University, Odense C, Denmark

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  3. Steven M. Paul

    1. Clinical Neuroscience Branch, National Institute of Mental Health, Bethesda, USA

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  4. William Z. Potter

    1. Section on Clinical Psychopharmacology, Laboratory of Clinical Science, Building 10, National Institute of Mental Health, Bethesda, USA

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Part of the book series: Psychopharmacology Series (PSYCHOPHARM, volume 3)

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Table of contents (31 papers)

  1. Front Matter

    Pages I-XII
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  2. Molecular Pharmacology in Drug Development

    1. Front Matter

      Pages 1-1
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    2. Molecular Modeling in Drug Design

      • G. R. Marshall
      Pages 3-11

    3. Synthesis of New Peptides Based on Models of Receptor-Bound Conformation

      • R. M. Freidinger, S. F. Brady, W. J. Paleveda, D. S. Perlow, C. D. Colton, W. L. Whitter et al.
      Pages 12-19

    4. Molecular Approach to the Mechanism of Action of Antidepressant Drugs

      • A. Wagner, P. Fork
      Pages 20-26

  3. Anxiolytics

    1. Front Matter

      Pages 27-27
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    2. Modulation of the Benzodiazepine-GABA Receptor Chloride Ionophore Complex by Multiple Allosteric Sites: Evidence for a Barbiturate “Receptor”

      • P. Skolnick, H. Havoundjian, S. M. Paul
      Pages 29-36

    3. β-Carbolines: New Insights into the Clinical Pharmacology of Benzodiazepine Receptor Ligands

      • R. Dorow, T. Duka, N. Sauerbrey, L. Höller
      Pages 37-51

    4. Pharmacodynamic Approaches to Benzodiazepine Action in Man

      • D. W. Hommer, V. Matsuo, O. M. Wolkowitz, H. Weingartner, S. M. Paul
      Pages 52-61

    5. Correlating Pharmacokinetics and Pharmacodynamics of Benzodiazepines: Problems and Assumptions

      • D. J. Greenblatt, H. L. Friedman, R. I. Shader
      Pages 62-71

    6. Benzodiazepine-Serotonin Interactions in Man

      • D. J. Nutt, P. J. Cowen
      Pages 72-76

    7. Comparative Pharmacodynamics of Benzodiazepines

      • E. H. Ellinwood Jr., A. M. Nikaido, D. G. Heatherly
      Pages 77-82

    8. Abuse Liability of Triazolam: Experimental Measurements in Animals and Humans

      • R. R. Griffiths, N. A. Ator, J. D. Roache, R. J. Lamb
      Pages 83-87

    9. Clinical Studies of “Specific” Anxiolytics as Therapeutic Agents

      • K. Rickels
      Pages 88-95

  4. Antidepressants

    1. Front Matter

      Pages 97-97
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    2. Regulation of Beta Adrenergic and Serotonin-S2 Receptors in Brain by Electroconvulsive Shock and Serotonin

      • K. J. Kellar, C. A. Stockmeier, A. M. Martino
      Pages 99-106

    3. α2-Adrenoceptor Antagonists as Antidepressants: The Search for Selectivity

      • R. M. Pinder, J. M. A. Sitsen
      Pages 107-112

    4. GABA Synapses, Depression, and Antidepressant Drugs

      • K. G. Lloyd, P. Pichat
      Pages 113-126

    5. Antidepressant Monoamine Oxidase Inhibitors Enhance Serotonin but not Norepinephrine Neurotransmission

      • P. Blier, C. de Montigny
      Pages 127-134

    6. Selective Amine Oxidase Inhibitors: Basic to Clinical Studies and Back

      • D. L. Murphy, T. Sunderland, N. A. Garrick, C. S. Aulakh, R. M. Cohen
      Pages 135-146
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Keywords

About this book

The Fourth International Meeting on Clinical Pharmacology in Psychiatry was held in Bethesda, Maryland on 5-8 September 1985 and was dedicated to the memory of Dr. Earl Usdin. Earl was one of the organizers of the three previous meetings held in Chicago (1979), Troms0 (1980), and Odense (1982). During the organization of the fourth meeting Earl became ill and had to relinquish his role as one of the principal organizers. It is safe to conclude that there was no better, or more professional, or more efficient an organizer of scientific meetings in the field of neuropharmacology and psychiatry than Earl U sdin, and it was quite a task for the remaining organizers to fill the void left when he withdrew from this one. Those of us who have organized previous meetings with Earl were struck by how much more difficult our work became without him. This obviously speaks well for his subtle (and at times not so subtle) organizational skills. Nevertheless, in Earl's memory the organizers proceeded to invite a group of internationally renowned neuropsychopharmacologists to address the problem of selectivity in psychotropic drug action and to try to reconcile the amazing advances in basic preclinical neuropsychopharmacology with the problem of clinical specificity encountered by the psychiatrist.

Editors and Affiliations

  • Department of Pharmacology, Institute of Medical Biology, University of Tromsø School of Medicine, Tromsø, Norway

    Svein G. Dahl

  • Department of Clinical Pharmacology, School of Medicine, Odense University, Odense C, Denmark

    Lars F. Gram

  • Clinical Neuroscience Branch, National Institute of Mental Health, Bethesda, USA

    Steven M. Paul

  • Section on Clinical Psychopharmacology, Laboratory of Clinical Science, Building 10, National Institute of Mental Health, Bethesda, USA

    William Z. Potter

Bibliographic Information

  • Book Title: Clinical Pharmacology in Psychiatry

  • Book Subtitle: Selectivity in Psychotropic Drug Action — Promises or Problems?

  • Editors: Svein G. Dahl, Lars F. Gram, Steven M. Paul, William Z. Potter

  • Series Title: Psychopharmacology Series

  • DOI: https://doi.org/10.1007/978-3-642-71288-3

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1987

  • Softcover ISBN: 978-3-642-71290-6Published: 19 November 2011

  • eBook ISBN: 978-3-642-71288-3Published: 06 December 2012

  • Series ISSN: 0931-6795

  • Edition Number: 1

  • Number of Pages: XII, 290

  • Topics: Psychiatry, Pharmacology/Toxicology

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