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Acute Leukemias

Prognostic Factors and Treatment Strategies

  • Conference proceedings
  • © 1987

Overview

Editors:
  1. T. Büchner

    1. Departments of Internal Medicine and Pediatrics, University of Münster, Münster, Federal Republic of Germany

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  2. G. Schellong

    1. Departments of Internal Medicine and Pediatrics, University of Münster, Münster, Federal Republic of Germany

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  3. W. Hiddemann

    1. Departments of Internal Medicine and Pediatrics, University of Münster, Münster, Federal Republic of Germany

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  4. D. Urbanitz

    1. Departments of Internal Medicine and Pediatrics, University of Münster, Münster, Federal Republic of Germany

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  5. J. Ritter

    1. Departments of Internal Medicine and Pediatrics, University of Münster, Münster, Federal Republic of Germany

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Part of the book series: Haematology and Blood Transfusion Hämatologie und Bluttransfusion (HAEMATOLOGY, volume 30)

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Table of contents (104 papers)

  1. Front Matter

    Pages I-XXVI
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  2. Biology, Cytogenetics and Morphology in Acute Leukemias

    1. Front Matter

      Pages 1-1
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    2. Cell Kinetics in Leukemia and Preleukemia

      • P. Dörmer, G. Ucci, Ch. Hershko, W. Wilmanns
      Pages 3-9

    3. Acute Nonlymphocytic Leukemia in Adults: Pathophysiology, Status of Current Therapy, and New Approaches

      • R. H. Mertelsmann, F. Herrmann
      Pages 10-14

    4. Prognostic Significance of Chromosome Changes in Acute Leukemia

      • A. A. Sandberg
      Pages 15-20

    5. Morphological and Cytochemical Classification of Adult Acute Leukemias in Two Multicenter Studies in the Federal Republic of Germany

      • H. Löffler, W. Kayser, N. Schmitz, E. Thiel, D. Hoelzer, T. Büchner et al.
      Pages 21-27

  3. Acute Myeloid Leukemia in Adults

    1. Front Matter

      Pages 29-29
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    2. Therapeutic Strategies in Acute Myelocytic Leukemia: A Status Report of the Experience of CALGB

      • K. R. Rai, J. Cuttner, J. F. Holland, R. Davis, R. Mayer, O. R. McIntyre et al.
      Pages 31-34

    3. The Ninth British Medical Research Council Trial for the Treatment of Acute Myeloid Leukaemia

      • J. K. H. Rees, R. Gray, F. G. J. Hayhoe
      Pages 35-37

    4. Long-Term Results of Two Swiss AML Studies

      • C. Sauter, P. Alberto, W. Berchtold, M. Fopp, J. Gmür, A. Gratwohl et al.
      Pages 38-44

    5. Prediction of Induction and Duration of Complete Remission in Acute Myelogenous Leukemia: Value of Clonogenic Cell Properties

      • R. Zittoun, J. P. Marie, D. Brilhante, A. Delmer
      Pages 45-49

    6. Remission Induction and Maintenance Modalities in Acute Myeloid Leukemia: A Multicenter Randomized Study

      • M. Marty, E. Lepage, H. Guy, D. Bordessoule, B. Desablens, J. L. Harousseau et al.
      Pages 50-56

    7. Postinduction and Preremission Chemotherapy Alternatives for Adult AML: Three Multicenter Studies of the AML Cooperative Group

      • T. Büchner, W. Hiddemann, D. Urbanitz, H. Kreutzmann, G. Maschmeyer, F. Wendt et al.
      Pages 57-63

    8. Neuraminidase-Treated Allogeneic Blasts for Maintenance in Acute Myelogenous Leukemia: Results of a Prospective Randomized Trial

      • D. Urbanitz, Th. Büchner, H. Pielken, P. Koch, W. D. Ludwig, G. Maschmeier et al.
      Pages 64-68

  4. Acute Myeloid Leukemia in Children

    1. Front Matter

      Pages 69-69
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    2. The Childhood AML Studies BFM-78 and -83: Treatment Results and Risk Factor Analysis

      • U. Creutzig, J. Ritter, H. Riehm, M. Budde, G. Schellong
      Pages 71-75

    3. Improved Treatment Results in Childhood Acute Nonlymphoblastic Leukemia with the BFM-AML Protocol 78 in a Multicenter Study in the GDR

      • J. Hermann, W. Plenert, F. Zintl, D. Fuchs, H. Malke, W. Dörffel et al.
      Pages 76-82

    4. A Comparison of Cytokinetically Based Versus Intensive Chemotherapy for Childhood Acute Myelogenous Leukemia

      • G. V. Dahl, D. K. Kalwinsky, J. Mirro, A. T. Look
      Pages 83-87

    5. Postremission Induction Intensive Sequential Chemotherapy for Children with AML — Treatment Results and Prognostic Factors

      • H. Weinstein, H. Grier, R. Gelber, B. Camitta, M. Link, M. Delorey et al.
      Pages 88-92

  5. Acute Lymphoblastic Leukemia in Adults

    1. Front Matter

      Pages 93-93
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Keywords

About this book

The progress in the treatment of childhood and adult acute leukemias within the last 10-15 years was pioneered by the work of single institl:tions incorporating modern leukemia cell research and pharmacology into the design of chemotherapeutic regimens. These new approaches, however, had to be validated by representative prospective studies in order to clearly demonstrate the efficacy of special concepts and to identify prognostic determinants and differences between patient subgroups. It was therefore the aim of the First International Symposium "Acute Leukemias: Prognostic Factors and Treatment Strategies" held in Munster in 1986 to provide a broad overview over the present status of chemotherapy and bone marrow transplantation in childhood and adult leukemias with special emphasis on the results of multicenter trials recruiting large numbers of patients in Europe and oversea countries. In addition, new aspects of cytogenetics, leukemia cell biology and modern diagnostic techniques as well as improvements in supportive treatment were covered. In an attempt to summarize the major results presented during this meeting, which are given in detail in the present book, the following conclusions may be drawn: In adults with acute myeloid leukemia complete remissions are achieved in 60 to 70% of all patients and translate into long­ term remissions in 15 to 25% of responders. Monthly maintenance chemotherapy was found to prolong remission duration significantly. In addition, late intensification, early consolidation or, as a new approach.

Editors and Affiliations

  • Departments of Internal Medicine and Pediatrics, University of Münster, Münster, Federal Republic of Germany

    T. Büchner, G. Schellong, W. Hiddemann, D. Urbanitz, J. Ritter

Bibliographic Information

  • Book Title: Acute Leukemias

  • Book Subtitle: Prognostic Factors and Treatment Strategies

  • Editors: T. Büchner, G. Schellong, W. Hiddemann, D. Urbanitz, J. Ritter

  • Series Title: Haematology and Blood Transfusion Hämatologie und Bluttransfusion

  • DOI: https://doi.org/10.1007/978-3-642-71213-5

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1987

  • Softcover ISBN: 978-3-540-16556-9Due: 01 May 1987

  • eBook ISBN: 978-3-642-71213-5Published: 06 December 2012

  • Series ISSN: 0440-0607

  • Edition Number: 1

  • Number of Pages: XXVI

  • Number of Illustrations: 25 b/w illustrations

  • Topics: Oncology, Pediatrics, Hematology

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