Immunology of the Neonate

1. Front Matter

   Pages I-IX

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2. Immunologic Development Introductory Remarks

   • Robert A. Good

   Pages 1-4

3. T-Cell Development

   • O. Stutman

   Pages 5-26

4. Humoral Immunity in the Human Neonate

   • Joseph L. Butler, Takayo Suzuki, Hiromi Kubagawa, Max D. Cooper

   Pages 27-36

5. Regulation of Antibody Synthesis in the Neonate

   • Ulf Andersson

   Pages 37-50

6. The Ontogeny of the Immune Response: The Role of Maternal Factors

   • L. Å. Hanson, I. Adlerberth, B. Carlsson, U. Dahlgren, Fehmida Jalil, Shaukat R. Khan et al.

   Pages 51-58

7. Mononuclear Phagocyte Function in the Perinatal Period

   • A. Biondi, G. Poli, C. Parravicini, A. Molinari, A. Mantovani

   Pages 59-66

8. Mechanisms of Abnormal Neutrophil Function in the Human Neonate: Prospects for Therapy

   • Harry R. Hill, Fulvio Sacchi

   Pages 67-75

9. Complement Function in the Neonate

   • F. Sessions Cole

   Pages 76-82

10. Modulation of Nonspecific Defense Mechanisms in the Neonate

    • Francesco Laurenti

    Pages 83-93

11. T-Cell Development and Function: Relationship to Immunodeficiencies

    • F. Aiuti, R. Paganelli, B. Ensoli, M. Crescenzi, M. Carbonari, M. Fiorilli

    Pages 94-99

12. Activation and Functional Capacity of Neonatal T Cells: Analysis of Interleukin-2 and Interleukin-2 Receptor Responsiveness

    • David L. Nelson

    Pages 100-111

13. Development of Lymphocyte Responses to Herpes Simplex Virus Following Neonatal Infection

    • Anthony Hayward, Paul Leibson, Ann Arvin

    Pages 112-119

14. T and NK Lymphocyte Subpopulations in the Neonate

    • Rita Maccario, G. R. Burgio

    Pages 120-129

15. Analysis of the Immunological Dysregulation Underlying Defective Interferon γ Secretion in the Human Neonate

    • J. L. Virelizier, N. Wakasugi

    Pages 130-134

16. Immunity and Infections in the Neonate

    • Joseph A. Bellanti, Barbara J. Zeligs

    Pages 135-144

17. Intravenous Gammaglobulin Replacement for Prophylaxis of Infection in Preterm Neonates

    • Gaetano Chirico, Giorgio Rondini, Alessandro Plebani, Alberto Chiara, Alberto G. Ugazio

    Pages 145-152

18. Prevention of Atopy: Neonatal Aspects

    • Robert N. Hamburger, Seth M. Asser

    Pages 153-160

19. Treatment of Infants with Severe Combined Immunodeficiency by Bone Marrow or Fetal Liver Transplantation

    • Jean-Louis Touraine

    Pages 161-169

20. Summing Up

    • Robert A. Good

    Pages 170-185

Over the last few years, many new observations have profoundly changed our concepts of the immune competence of the newborn. For the immune system, as for other systems and functions, the neonatal age represents a crucial transition period. In fact the immune characteristics of the fetus are likely to result fro- or be conditioned by - several often contradictory physiological requirements. On the one hand, it would certainly be an advantage for the fetus to acquire a complete immunocompetence as soon as possible in order to be able to cope with the eventual transplacental passage of pathogenic microorganisms and possibly also in order to reject maternal cells occasionally crossing the placental nd barrier. This is actually what occurs, at least in part, during the 2 and Jfd month of gestation when the fetus begins to acquire his biological individuality and at the same time the role of a "biological ego" resulting from the attain­ ment by the immune system of the capacity to discriminate between self and nonself.

• fetus
• immune system
• immunology
• newborn
• placenta

• Clinica Pediatrics, Universitá di Pavia, Pavia, Italy

  G. Roberto Burgio

• Institute of Clinical Microbiology, University of Götebôrg, Göteborg, Sweden

  Lars Åke Hanson

• Clinica Pediatrica Ospedale dei Bambini, University of Brescia, Brescia, Italy

  Alberto G. Ugazio

Policies and ethics