Design and Synthesis of Organic Molecules Based on Molecular Recognition

1. Front Matter

   Pages I-XV

   PDF

2. Introduction

   1. Design and Synthesis of Organic Molecules Based on Molecular Recognition

      • Ephraim Katchalski-Katzir

      Pages 1-28

3. Molecular Recognition in Biochemical Processes

   1. Front Matter

      Pages 29-29

      PDF

   2. Reports

      1. Specific Reversible Interactions in Life Processes: Antenna Function of Membranes and Their Regioselective, Conformation Selective and Stereoselective Interactions with Regulatory Peptides

         • Robert Schwyzer

         Pages 31-40

      2. Functional Significance of Flexibility in Proteins

         • Robert Huber, William S. Bennett Jr.

         Pages 41-42

   3. Communications

      1. Antibodies of Predetermined Specificity in Biology and Medicine

         • Richard Alan Lerner

         Pages 43-49

      2. Calcium Trigger Proteins

         • R. J. P. Williams

         Pages 50-51

      3. Glucagon Conformation in Different Environments: Implications for Molecular Recognition

         • K. Wüthrich

         Pages 52-56

4. Thermodynamics, Kinetics and Stereochemistry in Molecular Recognition

   1. Front Matter

      Pages 57-57

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   2. Reports

      1. On the Economics of Binding Energies

         • William P. Jencks

         Pages 59-80

      2. Dynamics of Ligand Binding to Proteins

         • Martin Karplus

         Pages 81-102

      3. Binding Energy and the Stimulation of Hormone Receptors

         • T. J. Franklin

         Pages 103-116

      4. Theoretical Studies of Molecular Recognition and Catalysis by Enzymes

         • Harold A. Scheraga

         Pages 117-136

   3. Communications

      1. Why Water?

         • A. R. Ubbelohde

         Pages 137-142

      2. Experimental Studies of Protein-Dynamics Through Ligand Binding

         • H. Frauenfelder

         Pages 143-149

5. Synthetic Models of “Hosts”

   1. Front Matter

      Pages 151-151

      PDF

   2. Reports

      1. Designed Host-Guest Relationships

         • D. J. Cram

         Pages 153-172

      2. Molecular Recognition: Design of Abiotic Receptor Molecules

         • J. M. Lehn

         Pages 173-184

      3. Biomimetic Control of Chemical Selectivity

         • R. Breslow

         Pages 185-197

      4. Biopolymers in Reverse Micelles as Guest — Host Molecular Systems

         • Pier Luigi Luisi, Linda Magid

         Pages 198-222

A topic for a Solvay Conference should be general enough to conform with the great tradition of previous conferences. On the other hand it should not be so broad that it can not be covered during the limited time of the conference. After discussion of several such topics, "Design and Synthesis of Organic Molecules Based on Molecular Recognition" was chosen. According to Albert Einstein we live in an era of perfect methods and confused aims. For example in organic chemistry the known synthetic methods allow us to prepare an astronomical number of compounds; the gap between the possible and the relevant becomes larger every day. After discovery and classification of the main types of reactions, the study of the selectivity of reactions becomes of paramount importance. One can learn quite a lot from Nature, which uses molecular recognition to achieve selec­ tivity in a degree so far unattainable by mere mortals. To analyze the structural features applied by Nature, to accomplish high molecular recog­ nition, and to simulate these features by synthesis have recently become therefore favorite occupations of chemists. The purpose of this conference was to bring together two groups, the analysts and the syntheticists, to discuss the present status of the knowledge. This monograph contains the chairman's introduction in which he has summarized the main points at issue and the contributions of the renowned scientists who participated. The organizers hope that it will stimulate further research in this fascinating field.

• Albert Einstein
• Aldehyde
• Design
• Molecules
• Peptid
• Protein
• chemistry
• classification
• molecule
• organic chemistry
• polymer
• reactions
• stereochemistry
• synthesis

• Fakulteit der Wetenschappen, Organische Chemie, Vrije Universiteit Brussels, Brussels, Belgium

  Georges Binst

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