Cadmium

1. Front Matter

   Pages I-XIV

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2. The Estimation of Cadmium in Biological Samples

   • K. Matsumoto, K. Fuwa

   Pages 1-31

3. Cadmium in the Environment and its Entry into Terrestrial Food Chain Crops

   • A. L. Page, M. M. El-Amamy, A. C. Chang

   Pages 33-74

4. Absorption of Cadmium

   • E. C. Foulkes

   Pages 75-100

5. The Chronic Toxicity of Cadmium: Influence of Environmental and Other Variables

   • K. Nomiyama

   Pages 101-133

6. Effects of Cadmium Exposure in Humans

   • A. Bernard, R. Lauwerys

   Pages 135-177

7. The Nephropathy of Chronic Cadmium Poisoning

   • M. Piscator

   Pages 179-194

8. Cadmium and the Cardiovascular System

   • J. Kopp

   Pages 195-280

9. Role of Metallothionein in Cadmium Metabolism

   • M. Webb

   Pages 281-337

10. Immunotoxicity of Cadmium

    • J. H. Exon, L. D. Koller

    Pages 339-350

11. The Effect of Dietary Selenium on Cadmium Cardiotoxicity

    • I. S. Jamall, J. C. Smith

    Pages 351-361

12. Cellular Resistance to Cadmium

    • M. D. Enger, C. E. Hildebrand, J. Seagrave, R. A. Tobey

    Pages 363-396

13. Back Matter

    Pages 397-402

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The toxic properties of cadmium compounds have been well recognized in many species. There is little evidence to suggest a physiologic role for the metal. Rather, because of its long biologic half-life, cadmium acts as a cumulative poison, and even at quite low ambient concentrations, it can accumulate in mammals to values not insignificant in terms of critical toxic levels. The problem of cadmium toxicity has become especially important, as cadmium concentrations in the environment have begun to rise owing to a variety of human activities such as mining, the metallurgical industry, coal combustion, and the use of cadmium-containing fertilizers. It seemed appropriate, therefore, to assemble in one volume an up-to-date analysis of the mechanism of action of cadmium on biologic systems. Aspects of this field have repeatedly been reviewed in the past, and particular reference must be made to the volumes prepared by FRIBERG and collaborators from Sweden. Much outstanding work on cadmium has also been reported from Japan, and I am happy that investigators from both countries were able to contribute to the present volume. Obviously, this volume does not report a consensus by its contributors. The purpose of the work was to permit leading investigators in the field to present a critical review with sufficient documentation to support their interpretations and conclusions. A certain amount of overlap and disagreement between chapters was therefore unavoidable. The result, I hope, will be a useful state-of-the-art discussion.

• absorption
• antibody
• cardiovascular system
• chemistry
• combustion
• documentation
• kidney
• kinetics
• metabolism
• nutrition
• poison
• resistance
• toxicity
• toxicology

• Department of Environment Health(56), University of Cincinnati, College of Medicine, Cincinnati, USA

  Ernest C. Foulkes

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