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Drugs and Aging

  • Conference proceedings
  • © 1986

Overview

Editors:
  1. Dieter Platt

    1. Universität Erlangen-Nürnberg, Nürnberg, Germany
      2. Medizinischen Klinik Klinikum Nürnberg, Nürnberg, Germany

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Table of contents (20 papers)

  1. Front Matter

    Pages I-XI
    Download chapter PDF

  2. Age-Related Changes of Transcription and RNA Processing

    • Z. A. Medvedev
    Pages 1-19

  3. Aging and Drug Testing in Cultured Normal Human Cells

    • L. Hayflick
    Pages 20-34

  4. Aging, Cancer, and the Life Span of Cells in Vitro

    • A. Macieira-Coelho, B. Azzarone
    Pages 35-44

  5. The Effect of Age on Rat Liver Drug Metabolism

    • C. F. A. Van Bezooijen, G. J. M. J. Horbach, C. F. Hollander
    Pages 45-55

  6. Effects of Hydrocortisone and Heparin on Growth and Glycosaminoglycan Synthesis of Cultured Human Fibroblasts (WI-38)

    • D. O. Schachtschabel, G. Sluke, J. Wever
    Pages 56-69

  7. The Influence of Esberitox on the Phagocytic Activity of Young and Old Isolated Perfused Rat Livers

    • T. Vömel, D. Platt
    Pages 70-79

  8. Age-Dependent Differences of the Therapeutic Effect on Experimental Liver Fibrosis and Cirrhosis (Morphology and Biochemistry)

    • J. Lindner, R. Eurich, K. Grasedyck, P. Schmiegelow, A. Nüssgen
    Pages 80-103

  9. Developmental and Age-Dependent Changes of Proteoglycan Metabolism in Normal and Experimentally Injured Liver and the Effects of Drugs

    • A. M. Gressner
    Pages 104-113

  10. Age Dependence of the Structure and Metabolism of Joint Cartilage and the Influence of Drugs

    • H. Greiling
    Pages 114-122

  11. Hypoxia and Ischemia of the Aged Brain: Pharmacotherapeutic Implications

    • S. Hoyer
    Pages 123-130

  12. Age-Dependent Actions of Benzodiazepines

    • U. Klotz
    Pages 131-139

  13. Influence of Age and Weight on Glycoside Therapy

    • A. Ruiz-Torres, R. Velasco
    Pages 140-143

  14. Pharmacokinetics of Acebutolol in the Elderly

    • W. Möhrke, E. Mutschler, W. Mühlberg, D. Platt
    Pages 144-151

  15. Pharmacodynamics of Acebutolol in Geriatric Patients with Multiple Diseases

    • W. Mühlberg, D. Platt, E. Mutschler, W. Möhrke
    Pages 152-163

  16. Age-Dependent Pharmacokinetics of Atenolol in Patients with Multiple Diseases

    • H. Spahn, W. Mühlberg, E. Mutschler, D. Platt
    Pages 164-170

  17. Long-Term Effects of Heterologous Fetal Testis Material on the Biological Age of the Male Rat

    • G. Hofecker, M. Skalicky, H. Niedermüller, A. Kment
    Pages 171-182

  18. Drug Albumin Binding Kinetics in the Aged: Conformational Changes and the Effect of Fatty Acids

    • G. Menke, P. Pfister, A. H. Staib, B. G. Woodcock, I. Rietbrock
    Pages 183-190

  19. Drug Interactions in Geriatric Patients

    • M. R. P. Hall
    Pages 191-196

  20. Plasma Concentration Measurement and Clinical Parameters in a Geriatric Population Treated for Cardiac Insufficiency Using the Nonrenal-Dependent Cardiac Glycoside Pentaformylgitoxin (Gitoformate)

    • B. G. Woodcock, S. Kubin, R. Schmitt-Rüth
    Pages 197-201
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Keywords

About this book

Experimental gerontological research is necessary to obtain optimal information and thus ensure proper drug therapy for the elderly. Most older persons acquire multiple diseases, first of all chronic diseases. They involve complex problems of a physical, social, and psychological nature. The multimorbidity of the elderly raises many questions in drug therapy. By contrast with our extensive knowledge of pharmacokinetics and pharmacodynamics in younger age groups, few facts are available in respect of the elderly. A variety of factors may influence drug therapy. Physiological and pathological age-related changes of molecules, cells, organs, and the total organism may interact to enhance or inhibit drug therapy in higher age groups. It is well known that elderly patients are overmedicated and therefore the incidence of adverse drug reactions increases with age. Elderly patients with multimorbidity often have a diminished body clearance of drugs; age-related changes of the kidney seems to be one of the most important factors in this regard. Far less important than the elimination of drugs through the kidney is their excretion in the bile. So far results have disclosed that oxidative steps in drug clearance are more likely to be disturbed than phase II reactions. Furthermore; changes in distribution volume and age-related alterations in receptor sensitivity also influence the clearance of drugs in the elderly.

Editors and Affiliations

  • Universität Erlangen-Nürnberg, Nürnberg, Germany

    Dieter Platt

  • 2. Medizinischen Klinik Klinikum Nürnberg, Nürnberg, Germany

    Dieter Platt

Bibliographic Information

  • Book Title: Drugs and Aging

  • Editors: Dieter Platt

  • DOI: https://doi.org/10.1007/978-3-642-70788-9

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1986

  • Softcover ISBN: 978-3-642-70790-2Published: 17 November 2011

  • eBook ISBN: 978-3-642-70788-9Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XI, 216

  • Topics: Internal Medicine, Pharmacology/Toxicology

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