The Influence of Antibiotics on the Host-Parasite Relationship II

1. Front Matter

   Pages I-XIV

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2. The Influence of Antibiotics on the Morphology and the Surface of Bacteria

   1. Front Matter

      Pages 1-1

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   2. Effect of Subinhibitory Concentrations of Antibiotics on Surface Proteins of Neisseria gonorrhoeae and Neisseria meningitidis: Changes that Alter Attachment to Human Cells

      • D. S. Stephens, Zell A. McGee

      Pages 3-15

   3. Interaction of Aminoglycosides and Ciprofloxacin with Bacterial Membranes

      • A. Dalhoff

      Pages 16-27

   4. The Influence of Ciprofloxacin on the Ultrastructure of Gram-negative and Gram-positive Bacteria

      • W.-H. Voigt

      Pages 28-35

   5. Exposure of protein antigens and reduction of siderophore production after growth of Gram-negative bacteria in Subinhibitory concentrations of cephalosporins

      • J. L. Kadurugamuwa, H. Anwar, M. R. W. Brown, O. Zak

      Pages 36-47

   6. The Influence of β-Lactam Antibiotics Including Monobactam on the outer and inner Membrane of E. coli

      • H. J. Leying, H. Karch, H. P. Kroll, W. Opferkuch

      Pages 48-56

   7. Changes in outer Membrane Composition after Treatment of Proteus mirabilis with Antibiotics

      • Kathryn Nixdorff, H. H. Martin, Nicola Siegmund-Schultze

      Pages 57-64

   8. Weight and Morphology of Bacteria Exposed to Antibiotics

      • V. Lorian, W. Tosch, D. Joyce

      Pages 65-72

3. The Influence of Antibiotics on Immunogenicity

   1. Front Matter

      Pages 73-73

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   2. Immunogenicity of Bacteria Treated in vitro with Subinhibitory Concentrations of Antibiotics

      • H. Friedman

      Pages 75-83

   3. Influence of Subminimal Inhibitory Concentrations of Antibiotics on Antigen Expression and Metabolic Activity of Salmonella Species

      • G. Gillissen, B. Melzer

      Pages 84-95

   4. Influence of Ciprofloxacin on Specific Interactions on Listeria-specific T Cells with Antigen in vitro

      • H. Hahn, Beate Wos, U. Sperling

      Pages 96-103

4. The Influence of Antibiotics on the Interaction of Bacteria with Host Defence Mechanisms

   1. Front Matter

      Pages 105-105

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   2. Serum Bactericidal Activity

      1. Effects of Antibiotics on the Sensitivity of <i>Proteus mirabilis</i> to the Bactericidal Action of Normal Human Serum

         • Nicola Siegmund-Schultze, H. H. Martin, Kathryn Nixdorff

         Pages 107-116

      2. Imipenem Renders Serum resistant <i>Enterobacter aerogenes</i> and <i>Escherichia coli</i> to Serum sensitive Bacteria

         • C. Wiemer, B. Kubens, W. Opferkuch

         Pages 117-124

   3. Phagocytosis

      1. Influence of subinhibitory concentrations of Clindamycin on the phagocytosis of Staphylococcus aureus

         • Etèl Veringa, J. Verhoef

         Pages 125-130

      2. The Effect of Antibiotics on the Killing of <i>E. Coli</i> by Macrophages of the Cell Line P 388 D1

         • M. Pawelzik, C. Wiemer, K. H. Büscher, W. Opferkuch

         Pages 131-140

      3. Antibiotics and Polyelectrolytes Modulate Bacteriolysis and the Capacity of Bacteria to Trigger an Oxygen Burst in Neutrophils

         • Isaac Ginsburg, Ruth Borinski, Milu Sadovnik, Sara Shauli, J. Wecke, P. Giesbrecht et al.

         Pages 141-151

      4. Chemiluminescence of Macrophages induced by Non-Opsonized <i>E.coli</i> treated with Subinhibitory Concentrations of β-lactam Antibiotics

         • K.-H. Büscher, H. Leying, M. Pawelzik, V. Klimetzek, W. Opferkuch

         Pages 152-158

The Second International Symposium on "The Influence of Antibiotics on the Host­ Parasite Relationship" was held in Munich, F. R. G. , from March 28 to 30,1985. The topics of the meeting dealt with the aspects of changes in bacterial metabolism and structure which occur under the influence of antibiotics, and with the effects of such changes on the antibacterial host resistance. The influence on pathogenicity factors, changes in the outer membrane of bacteria, as well as the influence on the individual components of the defence system were analysed in detail. In addition, these studies showed that antibiotics proved to be an excellent tool for the examination of bacterial physiology, so that, 50 years after the introduction of antibiotics, additional important knowledge can be gained about the effect of these substances on bacteria. Considering the observations reported, it appears justifiable to postulate that new antibiotics should be routinely tested with respect to their possible effects on antiinfectious resistance. Of course, a consensus will have to be found on which to base methods and criteria employ€d. The symposium documented an increasing interest of microbiologists and clini­ cians for this field of research. It would not have been possible to organize it without the substantial support of the Paul Ehrlich Society as well as of Squibb-Von Heyden Pharma, Inc. Particular help concerning the organization has been given by Werner Kremer of Squibb-Von Heyden Pharma.

• antibiotic
• antibiotics
• bacteria
• base
• metabolism
• parasite
• physiology
• resistance

• Kinderklinik der Universität München, München 2, Germany

  Dieter Adam

• Institut für Medizinische Mikrobiologie, Freie Universität Berlin, Berlin 45, Germany

  Helmut Hahn

• Abteilung für Theoretische und Klinische Medizin, Ruhr-Universität Bochum, Bochum 1, Germany

  Wolfgang Opferkuch

• Lehrstuhl für Medizinische Mikrobiologie und Immunologie, Ruhr-Universität Bochum, Bochum 1, Germany

  Wolfgang Opferkuch

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