Molecular Aspects of Neurobiology

1. Front Matter

   Pages I-XII

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2. Interrelationships of Cellular Mechanisms for Different Forms of Learning and Memory

   • P. Montarolo, S. Schacher, V. F. Castellucci, R. D. Hawkins, T. W. Abrams, P. Goelet et al.

   Pages 1-14

3. Serotonin Modulates the Action Potential in Growth Cone Precursors of Sensory Neuron Terminals in Aplysia

   • F. Belardetti, S. Schacher, E. R. Kandel, S. A. Siegelbaum

   Pages 15-18

4. Serotonin and cAMP Mediate Plastic Changes in Swimming Activity of Hirudo m

   • M. Brunelli, G. Demontis, G. Traina

   Pages 19-21

5. NGF Modulates the Synthesis of a Nuclear Lactic Dehydrogenase with Single-stranded DNA-Binding Properties

   • S. Biocca, A. Cattaneo, C. Volontè, P. Calissano

   Pages 22-28

6. Molecular Cloning of a Gene Sequence Induced by NGF in PC12 Cells

   • A. Levi, J. D. Eldridge, B. M. Paterson

   Pages 29-30

7. Thymocytes as Potential Target Cells for Nerve Growth Factor

   • A. Cattaneo

   Pages 31-36

8. Expression of the v-src Oncogene Induces Differentiation in PC12 Cells

   • P. Casalbore, E. Agostini, F. Tatò, S. Alemà

   Pages 37-39

9. Serum Influences β-NGF Gene Expression in Mouse L Cells

   • R. Houlgatte, D. Wion, P. Barrand, E. Dicou, P. Brachet

   Pages 40-42

10. Isolation of Glia Maturation Factor with HPLC and Verification with a Monoclonal Antibody

    • R. Lim, J. F. Miller

    Pages 43-47

11. Nicotinic Receptors from Different Peripheral Organs and from Brain are Highly Homologous, Complex Proteins

    • B. M. Conti-Tronconi, M. A. Raftery, S. M. J. Dunn

    Pages 48-53

12. Structure and Function of the Nicotinic Acetylcholine Receptor and of the Voltage-dependent Na+-Channel

    • M. A. Raftery, B. M. Conti-Tronconi, S. M. J. Dunn

    Pages 54-59

13. Molecular Cloning of Receptors for Acetylcholine

    • J. Boulter, K. Evans, S. Evans, P. Gardner, D. Goldman, S. Heinemann et al.

    Pages 60-65

14. The Molecular Biology of Acetylcholine Receptors from the Vertebrate Peripheral and Central Nervous Systems

    • J. F. Jackson, D. M. W. Beeson, V. B. Cockcroft, M. G. Darlison, B. M. Conti-Tronconi, L. D. Bell et al.

    Pages 66-74

15. Regulation of Synapse-specific Genes

    • J. P. Merlie, J. R. Sanes

    Pages 75-80

16. Asymmetrical Distribution of Membrane-bound Cytoskeleton Proteins at the Innervated and Non-innervated Membrane Domains in Torpedo Electrocytes

    • C. Kordeli, J. Cartaud, H. O. Nghiêm, J. P. Changeux

    Pages 81-84

17. In Search of the Binding Site of the Nicotinic Acetylcholine Receptor

    • J. M. Gershoni, D. Neumann, S. Fuchs

    Pages 85-87

18. Identification of Acetylcholine Receptors from the Central Nervous System of Insects

    • H. Breer

    Pages 88-90

19. The GABA/Benzodiazepine Receptor Complex: Function, Structure and Location

    • H. Möhler, P. Schoch, J. G. Richards

    Pages 91-96

20. TBPS Binding to the GABA/Benzodiazepine Receptor Complex in Cultured Cerebellar Granule Cells

    • V. Gallo, B. C. Wise, F. Vaccarino, A. Guidotti

    Pages 97-100

The past two decades may well become known as the golden era of neurobiology. This field, that in the first half of this century seemed far too complex to be investigated with the low resolution techniques available to the investigators, suddenly blossomed in the second half of the century into one of the most promising areas of biology, thanks to discoveries which took place practically simultaneously in most areas of neurobiological research. Here we mention only some of the most important: the discovery of the large number of neurotransmitters from monoamines to peptides, the identification of the mechanism of action of different agents through their binding to specific receptors, the recognition that neuro­ transmitters act most of the time through a second messenger, and the discovery that growth and differentiation of nerve cells depend on activation by the protein molecule; all these were recognized I!S specific growth facts, of which the NGF was both the frrst to be dis­ covered and the object of the most intensive investigation. Recently, the development of highly sophisticated techniques such as recombinant DNA and monoclonal antibodies has been suc­ cessfully applied at the cellular and subeellular level to the study of nerve cells, neuronal cell population, and to the mechanism of their interaction. Studies pursued with the collaboration of different investigators all over the world have opened a new panorama of the tremendous complexity of the CNS, from the neuron to the whole organism.

• Activation
• DNA
• Monoclonal Antibodies
• antibody
• biology
• cell
• cognition
• neurobiology
• neurotransmitter
• receptor

• Institute of Cell Biology, CNR, Rome, Italy

  Rita Levi Montalcini, Pietro Calissano

• Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, New York, USA

  Eric Richard Kandel

• Institute of Pharmacology and Pharmacognosy, University of Milano, Milano, Italy

  Adriana Maggi

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