Senile Dementia of the Alzheimer Type

1. Front Matter

   Pages I-XII

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2. Early Diagnosis of Senile Dementia of the Alzheimer Type

   1. Front Matter

      Pages 1-1

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   2. Behavioral and Clinical Aspects

      1. Cognitive Function in Normal Aging and Early Dementia

         • C. Flicker, S. H. Ferris, T. Crook, R. T. Bartus, B. Reisberg

         Pages 2-17

      2. Senile Dementia of the Alzheimer Type: Diagnostic and Differential Diagnostic Features with Special Reference to Functional Assessment Staging

         • B. Reisberg, S. H. Ferris, M. J. de Leon

         Pages 18-37

      3. Assessment of Cognition and Affective Symptoms in Dementia

         • R. C. Mohs, B. S. Greenwald, D. D. Dunn, K. L. Davis

         Pages 38-43

      4. The AGP System: Assessment of Symptoms in Psychogeriatric Patients

         • S. Kanowski, H. Krüger, K.-P. Kühl

         Pages 44-59

      5. Cognitive Deficits in Parkinson’s Disease

         • A. J. Lees

         Pages 60-71

      6. Differential Diagnosis: Depression Versus Dementia

         • J. R. M. Copeland, M. E. Dewey

         Pages 72-83

      7. Early Diagnosis of Dementia: Possible Contributions of Neuropsychology

         • J. Jolles

         Pages 84-100

   3. Brain Tissue Parameters

      1. EEG and Evoked Potentials in the Diagnosis of Dementias

         • S. L. Visser

         Pages 102-116

      2. Nuclear Magnetic Resonance and Early Diagnosis of Brain Pathology

         • W. L. Curati, R. E. Steiner

         Pages 117-123

      3. Positron Tomography and the Differential Diagnosis and Pathophysiology of Alzheimer’s Disease

         • R. P. Friedland, T. F. Budinger, W. J. Jagust, E. Koss, S. Derenzo, R. H. Huesman et al.

         Pages 124-133

      4. Investigation of Regional Cerebral Blood Flow and Metabolism in Dementia

         • W.-D. Heiss, G. Pawlik, K. Herholz, B. Szelies, C. Beil, K. Wienhard

         Pages 134-147

3. Novel Developments in the Neuropathology of Senile Dementia of the Alzheimer Type

   1. Front Matter

      Pages 149-149

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   2. Are Neurons of the Human Cerebral Cortex Really Lost During Aging? A Morphometric Examination

      • H. Haug

      Pages 150-163

   3. Senile Dementia of the Alzheimer Type: Morphological and Immunocytochemical Studies

      • J. P. Brion, P. van den Bosch de Aguilar, J. Flament-Durand

      Pages 164-174

   4. Neurotransmitter Receptor Alterations in Alzheimer’s Disease

      • P. J. Whitehouse, K.-S. Au

      Pages 175-182

   5. Co-Localization of Aluminium and Silicon in Senile Plaques: Implications for the Neurochemical Pathology of Alzheimer’s Disease

      • J. M. Candy, J. A. Edwardson, J. Klinowski, A. E. Oakley, E. K. Perry, R. H. Perry

      Pages 183-197

   6. Biochemical Changes in Alzheimer’s Disease: A Comment

      • A. N. Davison

      Pages 198-204

   7. The Nature of Neurofibrillary Tangles

      • B. H. Anderton, M. C. Haugh, J. Kahn, C. Miller, A. Probst, J. Ulrich

      Pages 205-216

Society is showing increasing concern for disorders related to aging that lead to a loss of brain function. In view of the enormous proportion of elderly people in our society today, brain aging is more than ever subject to challenge to us all, not only politicians and health authorities, but every individual who is confronted with the difficult situation of watching the mental powers of apparently healthy elderly friends, neighbours, or relatives fail, often with alarming rapidity. This challenge is directed especially toward us scientists. As one of our colleagues succinctly put it 2 years ago at the close of our First International Symposium on Brain Aging: "Do something. We are not dealing here with just another disease; we are concerned with human dignity. " More than any statistics, these words convinced me that Tropon's decision to leave the field of classic CNS pharmacology and move into the field of gerontopsychopharmacology was the right one, even though we knew that success would be uncertain and that, even if it finally comes it will be many years hence. At this point, let me add a personal comment: each one of us is judged by his or her own success. We live in a competitive society where success counts. This applies not only to the businessman, but also to the scientist, in particular, to those in industry.

• Alzheimer's disease
• Alzheimer´s disease
• Parkinson
• Staging
• brain
• cognition
• dementia
• depression
• electroencephalography (EEG)
• neuroanatomy
• neurons
• neuropathology
• neuropharmacology
• nuclear magnetic resonance (NMR)
• pathology

• Neurobiology Department, Troponwerke GmbH & Co. KG, Köln 80, Germany

  Jörg Traber

• Division of Molecular Neurobiology Rudolf Magnus Institute for Pharmacology and Institute of Molecular Biology, State University of Utrecht, Utrecht, The Netherlands

  Willem Hendrik Gispen

Policies and ethics