Nausea and Vomiting: Mechanisms and Treatment

1. Front Matter

   Pages I-IX

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2. The Multiple Causes of Vomiting: Is There a Common Mechanism?

   1. The Multiple Causes of Vomiting: Is There a Common Mechanism?

      • D. G. Grahame-Smith

      Pages 1-8

3. Anatomy, Physiology, and Pharmacology

   1. Front Matter

      Pages 9-9

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   2. Anatomy and Physiology of the Chemoreceptor Trigger Zone and Area Postrema

      • H. L. Borison

      Pages 10-17

   3. Neurochemical Investigations into the Human Area Postrema

      • J.-C. Schwartz, Y. Agid, M.-L. Bouthenet, F. Javoy-Agid, C. Llorens-Cortes, M.-P. Martres et al.

      Pages 18-30

   4. The Central Nervous Connections Involved in the Vomiting Reflex

      • K. R. Brizzee, W. R. Mehler

      Pages 31-55

   5. Peripheral Nervous Pathways Involved in Nausea and Vomiting

      • J. L. Willems, R. A. Lefebvre

      Pages 56-64

   6. The Organisation of Vomiting as a Protective Reflex

      • C. J. Davis, R. K. Harding, R. A. Leslie, P. L. R. Andrews

      Pages 65-75

4. Clinical Aspects

   1. Front Matter

      Pages 77-77

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   2. Mechanisms and Treatment of Cytotoxic-Induced Nausea and Vomiting

      • A. L. Harris, B. M. J. Cantwell

      Pages 78-93

   3. Mechanisms and Treatment of Radiation-Induced Nausea and Vomiting

      • R. W. Young

      Pages 94-109

   4. Mechanisms and Treatment of Motion Illness

      • J. R. R. Stott

      Pages 110-129

   5. Mechanisms and Treatment of Post-Operative Nausea and Vomiting

      • R. F. Cookson

      Pages 130-150

   6. Mechanisms and Treatment of Nausea and Vomiting in Pregnancy

      • D. V. I. Fairweather

      Pages 151-159

   7. A Neurologist’s View of Nausea and Vomiting

      • J. D. Parkes

      Pages 160-166

   8. Rational Approaches to Therapy for Nausea and Vomiting: Two Common Solutions

      • M. D. Rawlins, W. B. Taylor, D. N. Bateman

      Pages 167-171

   9. Clinical Discussions: An Overview

      • G. V. Lake-Bakaar

      Pages 172-175

5. Back Matter

   Pages 176-184

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The following papers were presented at an international symposium on the mechanisms and treatment of nausea and vomiting in man held in Oxford in 1984. I believe that this meeting was the first occasion on which representatives from such a wide variety of scientific and clinical specialities had come together to review and debate the spectrum of the vomiting phenomenon. An attempt was made to put before an invited international audience all the pertinent facts on the different facets of the topic and then to encourage extensive discussion of the contentious issues. The first day of the meeting was devoted to the basic science ap­ proach to the problem and the second day to the more clinical aspects. This format has been broadly retained in the layout of the book, with the addition of summary chapters reviewing each day's contributions and focusing upon areas of particular importance. Acknowledgement must here be made to the enormous input from the many participants who either spoke in the debate or rose and themselves gave small presenta­ tions in addition to those of the invited speakers. The meeting occurred at a time of increasing interest in the problem of nausea and vomiting, especially because of its importance in cancer chemotherapy and radiation therapy, and even in space travel.

• anatomy
• cancer
• chemotherapy
• physiology
• radiation
• radiation therapy
• therapy
• travel
• treatment
• hepatology

• Royal Navy, Corpus Christi College, Oxford, UK

  Christopher J. Davis

• University Department of Clinical Pharmacology, Radcliffe Infirmary, Oxford, UK

  Christopher J. Davis

• Medical Department, Janssen Pharmaceutical Ltd (UK), Wantage Oxfordshire, UK

  Gerry V. Lake-Bakaar

• University of Oxford, Oxford, UK

  David G. Grahame-Smith

• General Internal Medicine and Clinical Pharmacology, Oxford Health Authority, Oxford, UK

  David G. Grahame-Smith

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