Fundamentals of Immunology

1. Front Matter

   Pages I-X

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2. Tissue and Cells of the Immune System

   • Ivan Mota

   Pages 1-34

3. Activity of Immune Cells

   • Ivan Mota

   Pages 35-62

4. Antigens

   • Ivan Mota

   Pages 63-72

5. Antibodies

   • Otto G. Bier

   Pages 73-114

6. Complement

   • Wilmar Dias Da Silva

   Pages 115-138

7. The Major Histocompatibility Complex

   • Dietrich Götze, Reinhard Burger

   Pages 139-178

8. Antigen-Antibody Interaction

   • Otto G. Bier

   Pages 179-226

9. Blood Groups

   • Otto G. Bier

   Pages 227-242

10. Hypersensitivity

    • Ivan Mota

    Pages 243-296

11. Transplantation

    • Dietrich Götze, Ivan Mota

    Pages 297-316

12. Immuity

    • Dietrich Götze, Wilmar Dias da Silva

    Pages 317-358

13. Immunodeficiencies

    • Wilmar Dias Da Silva, Dietrich Götze

    Pages 359-382

14. Autoimmunity

    • Wilmar Dias Da Silva, Dietrich Götze

    Pages 383-413

15. Immunomodulation

    • Wilmar Dias Da Silva

    Pages 415-437

16. Back Matter

    Pages 439-469

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The good acceptance of this textbook is an indication that it has served its purpose. The present edition has been prepared in order to cover the main progress achieved in the five years that have elapsed since the first edition. The structure of the book remains essentially the same but a con­ siderable amount of new material has been introduced, particularly in certain areas such as the genetics of immunoglobulins and T cell receptor, the regulation of the immune response, hypersensitivity reactions, and cellular immunology. Today, immunology is essential for biologists in general and in particular for physicians, veterinarians, and pathologists. The great progress and diversification that has taken place in the last few years is due to its enormous value both for the understanding of theoretical biology and for the practical resolution of biochemical, genetic, pathological, and biological problems. Greatly contributing to this progress have been relatively sophisticated techniques, such as immunofluorescence, radioimmune assay, transmission electron micro­ scopy, scanning electron microscopy, isoelectric focusing, quantitative cytofluorimetry, affinity chromatography, and techniques that allow separation of the different lymphocyte subpopulations. A potentially fabulous field was recently opened with the development of techniques for obtaining monoclonal antibodies by fusion of immunologically active lymphocytes with myeloma cells. These hybrid cells produce large amounts of monoclonal antibodies or other lymphocyte factors. The establishment of this hybridoma technology, that is already routine in most laboratories, is being used in the resolution of general biology problems, particularly in the study of the various cell surface molecules.

• Antigen
• T cell
• autoimmunity
• blood
• genetics
• histocompatibility
• immunoglobulin
• immunomodulation
• lymphocytes
• transplantation

• Laboratório Especial de Imunologia Aplicada, Instituto Butantan, São Paulo, Brazil

  Otto G. Bier

• Instituto de Bioĉiencias, Departamento de Microbiologia e Imunologia, Cidade Universitária, São Paulo, Brazil

  Wilmar Dias Da Silva

• University Medical School, Heidelberg, Germany

  Dietrich Götze

• The Wistar Institute, Philadelphia, USA

  Dietrich Götze

• The University of Pennsylvania, Philadelphia, USA

  Dietrich Götze

• Centro de Imunologia da OMS/OPS, Instituto Butantan, São Paulo, Brazil

  Ivan Mota

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