HLA Class II Antigens

1. Front Matter

   Pages I-XVII

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2. Molecular Biology

   1. Genes and Antigens of the HLA-D Region

      • P. A. Peterson, L. Rask

      Pages 1-13

   2. Physiologic Regulation of Class II Major Histocompatibility Complex Gene Expression

      • T. Collins, J. S. Pober, J. L. Strominger

      Pages 14-31

   3. Epitopes Are the Functional Units of HLA Class II Molecules and Form the Molecular Basis for Disease Susceptibility

      • J. Silver, S. M. Goyert

      Pages 32-48

3. Biochemistry

   1. Structure of Human Class II Antigens Expressed by a Homozygous Lymphoblastoid B Cell Line

      • H. Kratzin, H. Götz, F. P. Thinnes, T. Kruse, H. U. Barnikol, P. Wernet et al.

      Pages 49-70

   2. The Complexity of HLA-DQ Molecules

      • R. Sorrentino, G. Corte

      Pages 71-82

   3. HLA-DP: Current Status

      • M. Sanchez-Perez, S. Shaw

      Pages 83-108

4. Genes Encoding Mouse Ia

   1. Structural and Functional Studies of Mouse Class II Genes

      • M. Steinmetz

      Pages 109-127

5. Cross-reaction Between Various Species

   1. Cross-reactions of Class II Histocompatibility Antigens of Various Species

      • M. Pla, P. Ivanyi

      Pages 128-153

6. Differences Between Ethnic Groups

   1. Human Class II Antigen in Different Ethnic Groups

      • K. Tsuji, K. Sato, Y. Nose, H. Inoko, T. Nakatsuji, A. Ando et al.

      Pages 154-168

7. Serological Definition

   1. Serology of HLA Class II Antigens: Methodological Aspects

      • P. Richiardi, E. S. Curtoni

      Pages 169-186

   2. Alloantisera Against Human Class II Antigens: Definition and Methodology

      • G. M. T. Schreuder, A. van Leeuwen

      Pages 187-203

   3. Monoclonal Antibodies Against HLA Class II Antigens

      • J. Colombani, V. Lepage

      Pages 204-223

   4. Preparation, Characterization, and Utilization of Monoclonal Antibodies to the Gene Products of the HLA-D Region, with Special Emphasis on Those to Polymorphic Determinants

      • M. Igarashi, L. Imberti, M. Maio, M. Tsujisaki, F. Perosa, K. Sakaguchi et al.

      Pages 224-248

8. Cellular Detection

   1. Cellular Detection of HLA Class II-Encoded Determinants: Subtype Polymorphisms of HLA-D

      • F. H. Bach, N. Ohta, A. Anichini, N. L. Reinsmoen

      Pages 249-265

   2. Cellular Detection of Human Class II MHC Antigens by Alloreactive T Cell Clones

      • R. J. Duquesnoy, A. Zeevi

      Pages 266-280

   3. Cellular Detection of Human Class II Antigens: Delineation of a Novel HLA-DP-like Suppressor Restriction System DY, the Sequential Expression of Class II Antigens, and a Pronounced Functional Flexibility of Class II Alloproliferative T Cell Clones

      • P. Wernet, G. Pawelec, E. M. Schneider

      Pages 281-298

9. Regulation and Expression

   1. Modulation of Class II Antigens by Interferons

      • F. Ameglio, R. Tosi, N. Tanigaki, A. Dolei

      Pages 299-313

   2. Changing Antigenic Profiles of HLA Class II Antigens on Activated T Cells and Their Biological Effects

      • H. Festenstein, L. Fainboim, D. Jaraquemada, C. Navarrete

      Pages 314-338

   3. Tissue Distribution of Class II Transplantation Antigens: Presence on Normal Cells

      • L. Klareskog, U. Forsum

      Pages 339-355

This volume deals with the structure and function of molecules that have, during the last decade, turned out to have a central role in immune responses. Trans­ plantation antigens were discovered and characterized by Gorer about 50 years ago, and the biological basis for the unequalled complexity of their variability between individuals within a species, in spite of extreme conservation between species, was the subject of intense research and discussion for many years. During the days of belief in "immune surveillance" against spontaneously developing tumors, it was suggested that histoincompatibility between members of one species would prevent cancer from being a contagious disease and thus a threat to the species. Immunologists involved in human transplantation had to learn and care about the complexity, especially after 1967, when it was found that HLA antigens were the products of the human MHC. Rejection of HLA-identical sib kidney grafts was so rare, even in those days, that cases of rejection were described in scientific papers.

• Histokompatibilität
• T cell
• antibody
• antigen
• diseases
• genetics
• hematopoiesis
• histocompatibility
• immune response
• interferon
• lymphocytes
• molecular biology
• molecular genetics
• transplantation

• Blood Bank and Immunohematological Laboratory, Rikshospitalet, National Hospital, Oslo 1, Norway

  Bjarte G. Solheim

• Karolinska Institute, Department of Clinical Immunology, Huddinge Hospital, Huddinge, Sweden

  Erna Møller

• Dept. of Microbiology and Immunology, New York Medical College, Valhalla, USA

  Soldano Ferrone

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