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HLA Class II Antigens

A Comprehensive Review of Structure and Function

  • Book
  • © 1986

Overview

Editors:
  1. Bjarte G. Solheim

    1. Blood Bank and Immunohematological Laboratory, Rikshospitalet, National Hospital, Oslo 1, Norway

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  2. Erna Møller

    1. Karolinska Institute, Department of Clinical Immunology, Huddinge Hospital, Huddinge, Sweden

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  3. Soldano Ferrone

    1. Dept. of Microbiology and Immunology, New York Medical College, Valhalla, USA

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Table of contents (32 chapters)

  1. Front Matter

    Pages I-XVII
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  3. Biochemistry

    1. Structure of Human Class II Antigens Expressed by a Homozygous Lymphoblastoid B Cell Line

      • H. Kratzin, H. Götz, F. P. Thinnes, T. Kruse, H. U. Barnikol, P. Wernet et al.
      Pages 49-70

    2. The Complexity of HLA-DQ Molecules

      • R. Sorrentino, G. Corte
      Pages 71-82

    3. HLA-DP: Current Status

      • M. Sanchez-Perez, S. Shaw
      Pages 83-108

  4. Genes Encoding Mouse Ia

    1. Structural and Functional Studies of Mouse Class II Genes

      • M. Steinmetz
      Pages 109-127

  5. Cross-reaction Between Various Species

    1. Cross-reactions of Class II Histocompatibility Antigens of Various Species

      • M. Pla, P. Ivanyi
      Pages 128-153

  6. Differences Between Ethnic Groups

    1. Human Class II Antigen in Different Ethnic Groups

      • K. Tsuji, K. Sato, Y. Nose, H. Inoko, T. Nakatsuji, A. Ando et al.
      Pages 154-168

  7. Serological Definition

    1. Serology of HLA Class II Antigens: Methodological Aspects

      • P. Richiardi, E. S. Curtoni
      Pages 169-186

    2. Alloantisera Against Human Class II Antigens: Definition and Methodology

      • G. M. T. Schreuder, A. van Leeuwen
      Pages 187-203

    3. Monoclonal Antibodies Against HLA Class II Antigens

      • J. Colombani, V. Lepage
      Pages 204-223

    4. Preparation, Characterization, and Utilization of Monoclonal Antibodies to the Gene Products of the HLA-D Region, with Special Emphasis on Those to Polymorphic Determinants

      • M. Igarashi, L. Imberti, M. Maio, M. Tsujisaki, F. Perosa, K. Sakaguchi et al.
      Pages 224-248

  9. Regulation and Expression

    1. Modulation of Class II Antigens by Interferons

      • F. Ameglio, R. Tosi, N. Tanigaki, A. Dolei
      Pages 299-313

    2. Changing Antigenic Profiles of HLA Class II Antigens on Activated T Cells and Their Biological Effects

      • H. Festenstein, L. Fainboim, D. Jaraquemada, C. Navarrete
      Pages 314-338

    3. Tissue Distribution of Class II Transplantation Antigens: Presence on Normal Cells

      • L. Klareskog, U. Forsum
      Pages 339-355
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Keywords

About this book

This volume deals with the structure and function of molecules that have, during the last decade, turned out to have a central role in immune responses. Trans­ plantation antigens were discovered and characterized by Gorer about 50 years ago, and the biological basis for the unequalled complexity of their variability between individuals within a species, in spite of extreme conservation between species, was the subject of intense research and discussion for many years. During the days of belief in "immune surveillance" against spontaneously developing tumors, it was suggested that histoincompatibility between members of one species would prevent cancer from being a contagious disease and thus a threat to the species. Immunologists involved in human transplantation had to learn and care about the complexity, especially after 1967, when it was found that HLA antigens were the products of the human MHC. Rejection of HLA-identical sib kidney grafts was so rare, even in those days, that cases of rejection were described in scientific papers.

Editors and Affiliations

  • Blood Bank and Immunohematological Laboratory, Rikshospitalet, National Hospital, Oslo 1, Norway

    Bjarte G. Solheim

  • Karolinska Institute, Department of Clinical Immunology, Huddinge Hospital, Huddinge, Sweden

    Erna Møller

  • Dept. of Microbiology and Immunology, New York Medical College, Valhalla, USA

    Soldano Ferrone

Bibliographic Information

  • Book Title: HLA Class II Antigens

  • Book Subtitle: A Comprehensive Review of Structure and Function

  • Editors: Bjarte G. Solheim, Erna Møller, Soldano Ferrone

  • DOI: https://doi.org/10.1007/978-3-642-70367-6

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1986

  • Softcover ISBN: 978-3-642-70369-0Published: 17 November 2011

  • eBook ISBN: 978-3-642-70367-6Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XVIII, 564

  • Topics: Allergology, Immunology

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