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The Pathogenesis of Bacterial Infections

  • Conference proceedings
  • © 1985

Overview

Editors:
  1. George Gee Jackson

    1. Department of Medicine, Section of Infectious Diseases, The University of Illinois at Chicago College of Medicine, Chicago, USA

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  2. Herbert Thomas

    1. Bayer AG, Pharma-Forschungszentrum, Institut für Chemotherapie, Wuppertal 1, Germany

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Bayer-Symposium (BAYER-SYMP, volume 8)

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Table of contents (48 papers)

  1. Front Matter

    Pages I-XVI
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  2. Welcome

    1. Welcome

      • H. Thomas
      Pages 1-2

  3. Introduction

    1. Introduction

      • G. G. Jackson
      Pages 3-5

  4. Infection of Mucosal Surfaces

    1. Front Matter

      Pages 7-7
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    2. Molecular Mechanisms by Which Pathogenic Bacteria Interact with Host Mucosal Cells

      • Z. A. McGee, E. N. Robinson Jr.
      Pages 8-16

    3. Antigen Expression Influencing Tissue Invasion of Hemophilus influenzae Type B

      • E. R. Moxon
      Pages 17-29

    4. Surface Factors and Nasopharyngeal Colonization by Hemophilus influenzae B

      • P. W. Anderson, Th. Inzana, M. Pichichero
      Pages 30-40

    5. The Molecular Organization of Gonococcal Pili

      • G. K. Schoolnik, J. B. Rothbard
      Pages 41-50

    6. Functions of the Outer Membrane Proteins of Neisseria gonorrhoeae

      • M. S. Blake
      Pages 51-67

    7. Regulation of Lipopolysaccharide Biologic Activity by Polysaccharide

      • D. C. Morrison, S. W. Vukajlovich, S. A. Goodman, H.-W. Wollenweber
      Pages 68-84

    8. Mucosal Immunoregulation: IgA Inductive Sites, Isotype-Specific Helper T Cells, Gut LPS Influence, and Subclass Distribution of IgA Antibodies

      • J. R. McGhee, S. M. Michalek, H. Kiyono, S. I. Williamson, T. A. Brown, J. Mestecky
      Pages 85-99

  5. Extension of Infection Beyond the Surface Cells — Circumvention of the Host Defense System

    1. Front Matter

      Pages 101-101
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    2. Molecular Interaction Between the Third Complement Protein and Bacterial Cell-Surface Macromolecules

      • R. P. Levine
      Pages 102-121

    3. Mechanisms of Bacterial Resistance to Complement-Mediated Killing

      • K. A. Joiner, M. M. Frank
      Pages 122-137

    4. Gram-Negative Septicemia: Antibody Deficiency and Specific Protection

      • L. S. Young
      Pages 138-146

    5. Mechanisms for Evasion and Survival of Bacteria by Perturbation of Phagocytes

      • P. G. Quie
      Pages 147-157

    6. Interacting T Cell Functions Elicited by Facultative Intracellular Bacteria

      • H. Hahn, H. Näher
      Pages 158-166

  6. Features of Bacterial Virulence

    1. Front Matter

      Pages 167-167
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    2. Iron Supply as a Virulence Factor

      • V. Braun
      Pages 168-176

    3. The Relationship Between Iron Utilization and Virulence of the Pathogenic Neisseria

      • D. W. Dyer, S. E. H. West, P. F. Sparling
      Pages 177-192
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Keywords

About this book

G. G. Jackson The pathogenesis of bacterial infection defines the dynamics at an interface of ecologic association of bacteria and host. First, it occurs at the portal of initial contact with a per­ missive target cell. The infected cell provides either a passive or a specific receptor for the bacterium or its products, to­ gether with ligands and an environment of helper and inhibiting factors. The result is bacterial replication to produce an im­ balance of a potentially commensal relation which, under other defined conditions, would be optimal for the survival of both the host and bacterial cells. Virulence and pathogenesis are both absolute and relative terms. They must be interpreted strictly according to the circumstances of site-specific inter­ actions of bacterial and host cells, membrane composition, structure, characteristics, and environmental substances. The bacteria themselves may have, acquire, or switch on or off under certain conditions, the products or properties that produce cellular damage that we recognize as virulence. Another result of bacterial infection may be to stimulate a normal host cell function to perform at a pathophysiologic level, causing illness that we recognize as virulence. A third marker of virulence may be the ability to invade a cell or tissue barrier and produce a pathologic effect at a site that is remote from the portal of commensal association or pathologic entry.

Editors and Affiliations

  • Department of Medicine, Section of Infectious Diseases, The University of Illinois at Chicago College of Medicine, Chicago, USA

    George Gee Jackson

  • Bayer AG, Pharma-Forschungszentrum, Institut für Chemotherapie, Wuppertal 1, Germany

    Herbert Thomas

Bibliographic Information

  • Book Title: The Pathogenesis of Bacterial Infections

  • Editors: George Gee Jackson, Herbert Thomas

  • Series Title: Bayer-Symposium

  • DOI: https://doi.org/10.1007/978-3-642-70351-5

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1985

  • Softcover ISBN: 978-3-642-70353-9Published: 17 November 2011

  • eBook ISBN: 978-3-642-70351-5Published: 07 March 2013

  • Series ISSN: 0067-4672

  • Edition Number: 1

  • Number of Pages: XVI, 432

  • Topics: Medical Microbiology

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