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Human T-Cell Leukemia Virus

  • Book
  • © 1985

Overview

Editors:
  1. Peter K. Vogt

    1. Department of Microbiology, University of Southern California School of Medicine, Los Angeles, USA

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Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 115)

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Table of contents (16 chapters)

  1. Front Matter

    Pages I-IX
    Download chapter PDF

  2. Human T-Cell Leukemia/Lymphoma Viruses — An Introduction

    • Peter K. Vogt
    Pages 1-5

  3. Isolation, Characterization, and Biological Effects of the First Human Retroviruses: The Human T-Lymphotropic Retrovirus Family

    • Marjorie Robert-Guroff, Philip D. Markham, Mikulas Popovic, Robert C. Gallo
    Pages 7-31

  4. Human T-Cell Leukemia/Lymphoma Viruses (HTLV): A Unique Family of Pathogenic Retroviruses

    • Hiroaki Mitsuya, Samuel Broder
    Pages 33-51

  5. Epidemiology of Adult T-Cell Leukemia/Lymphoma in Japan

    • Kazuo Tajima, Suketami Tominaga
    Pages 53-66

  6. Human T-Cell Leukemia/Lymphoma Viruses: Clinical and Epidemiologic Features

    • William A. Blattner, Robert C. Gallo
    Pages 67-88

  7. Clinical Aspects of Adult T-Cell Leukemia/Lymphoma

    • Kiyoshi Takatsuki, Kazunari Yamaguchi, Fumio Kawano, Hiromichi Nishimura, Motoharu Seiki, Mitsuaki Yoshida
    Pages 89-97

  8. The Epidemiology of Human T-Cell Leukemia/Lymphoma Virus

    • Yohei Ito
    Pages 99-112

  9. Adult T-Cell Leukemia/Lymphoma and Its Clinical Subtypes from the Viewpoints of Viral Etiology

    • Masanori Shimoyama
    Pages 113-125

  10. A Retrovirus Associated with a Human Leukemia, Adult T-Cell Leukemia

    • Yorio Hinuma
    Pages 127-141

  11. Biology of T-Cell Leukemia Virus: Search for an Animal System

    • Isao Miyoshi
    Pages 143-156

  12. Molecular Biology of Human T-Cell Leukemia Virus Associated with Adult T-Cell Leukemia

    • Mitsuaki Yoshida, Seisuke Hattori, Motoharu Seiki
    Pages 157-175

  13. Structure and Function of the Genome of HTLV

    • William A. Haseltine, Joseph G. Sodroski, Roberto Patarca
    Pages 177-209

  14. Some Perspectives on the Molecular Mechanism of In Vitro Transformation and In Vivo Leukemogenesis by HTLV

    • Flossie Wong-Staal
    Pages 211-220

  15. Primary Structure and Processing of gag and env Gene Products of Human T-Cell Leukemia Viruses HTLV-ICR and HTLV-IATK

    • Stephen Oroszlan, Terry D. Copeland
    Pages 221-233

  16. Envelope Properties of Human T-Cell Leukemia Viruses

    • Robin A. Weiss, Paul Clapham, Karoly Nagy, Hiroo Hoshino
    Pages 235-246

  17. Human T-Cell Leukemia/Lymphoma Virus: Studies of Host-Virus Interaction

    • Thomas J. Palker, Dani P. Bolognesi, Barton F. Haynes
    Pages 247-266
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Keywords

About this book

characteristic features in common with the genome of other retroviruses: long terminal repeats (L TR), and coding regions for internal proteins (gag), for re­ verse transcriptase (pol), and for glycosylated virion surface proteins (env) , ar­ ranged in the sequence gag, pol, env from the 5' to the 3' end of the genome. However, the HTL V genome also contains some specific features not shared with all other retroviruses: the LTR regions are unusually long (745 base pairs, with 298 base pairs constituting the R region), but unlike the long L TRs of mouse mammary tumor viruses, they do not contain open reading frames. A stretch of noncoding sequences separates the gag and the pol genes. Most interestingly, the HTLV genome contains a region between the 3' end of the env gene and the L TR, called the pX region, that encompasses four open reading frames. Leukemic T cells freshly obtained from patients contain the HTL V provirus but usually do not express it. However, once established in culture, these cells produce viral proteins and release type C particles. Likewise, T cells infected and transformed by HTL V in vitro synthesize virus. Such producing cell lines have been widely used in seroepidemiological surveys and continue to be of importance for detailed studies of viral proteins and nucleic acids.

Editors and Affiliations

  • Department of Microbiology, University of Southern California School of Medicine, Los Angeles, USA

    Peter K. Vogt

Bibliographic Information

  • Book Title: Human T-Cell Leukemia Virus

  • Editors: Peter K. Vogt

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-70113-9

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 1985

  • Softcover ISBN: 978-3-642-70115-3Published: 06 December 2011

  • eBook ISBN: 978-3-642-70113-9Published: 06 December 2012

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: X, 266

  • Topics: Medical Microbiology, Virology, Oncology

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