Cerebral Blood Flow and Metabolism Measurement

1. Front Matter

   Pages I-XV

   PDF

2. Intraarterial Xenon 133 Technique

   1. The Intraarterial Xenon 133 Method: Principles and Clinical Application

      • K. Kohlmeyer

      Pages 1-18

   2. Theoretical Limitations in the Use of Two-Dimensional rCBF for the Diagnosis of Cerebrovascular Disease

      • E. Ryding, B. Nilsson

      Pages 19-22

   3. Effect of STA-MCA Bypass on Hemispheric CBF and CO2 Reactivity in Patients with Hemodynamic TIAs and Watershed-Zone Infarctions

      • Y. Tsuda, K. Kimura, Y. Iwata, T. Hayakawa, H. Etani, T. Asai et al.

      Pages 23-29

3. Noninvasive Two-Dimensional rCBF Techniques

   1. Stability and Sensitivity of CBF Indices in the Noninvasive 133Xe Method

      • W. D. Obrist, W. E. Wilkinson

      Pages 30-36

   2. Two-Dimensional Measurements of rCBF by the Intravenous Xenon 133 Method

      • J. Seylaz, P. Meric

      Pages 37-50

   3. Correlation Between CBF and pCO2, pO2, pH, Hemoglobin, Blood Pressure, Age, and Sex

      • P. Gündling, J. Haneder, M. R. Gaab

      Pages 51-55

   4. Theoretical Evaluation and Simulation Test of the Initial Slope Index for Noninvasive rCBF

      • I. Prohovnik, E. Knudsen, J. Risberg

      Pages 56-60

   5. Inaccuracies in the Calculation of CBF from Inert Gas Clearance

      • R. von Kummer, S. Herold, F. von Kries

      Pages 61-66

   6. A Graphic Approach to Compartmental Slippage

      • K. Herholz, G. Pawlik, W.-D. Heiss, H. W. Ilsen, K. Wienhard

      Pages 67-71

   7. Application of the Nontraumatic Xenon 133 Method in Neuropsychiatry

      • J. Risberg

      Pages 72-80

   8. Distinct rCBF Pattern During Different Types of Short-Term Memory Activation

      • Z. Mubrin, S. Knežević, B. Barac, N. Gubarev, M. Lazić, R. Liščić et al.

      Pages 81-87

   9. rCBF and Neuropsychological Findings in Head Injury

      • B. P. Uzzell, C. A. Dolinskas, J. L. Jaggi, W. D. Obrist

      Pages 88-91

   10. Alterations of Cerebral Blood Flow in Slight Head Injury

       • E. Körner, K. Marguc, E. Ott, H. Lechner, E. Flooh, R. Szyszkowitz et al.

       Pages 92-97

   11. Is It Possible to Measure Regional Cerebral Blood Flow in Patients with Acute Cerebral Ischemia?

       • A. Hartmann

       Pages 98-108

   12. The Prognostic Value of rCBF Measurements in Aphasic Stroke Patients

       • G. Demeurisse, M. Verhas, A. Capon

       Pages 109-112

   13. The Detection of Cerebral Ischemia Using Xenon 133

       • J. K. Farrar

       Pages 113-117

   14. Intravenous Xenon 133 rCBF Measurement with a New Mobile System

       • T. Schroeder, P. Holstein, H. C. Engell

       Pages 118-122

   15. Rheological Determinants of Cerebral Blood Flow

       • E. Ott, F. Fazekas, G. Bertha, H. Valetitsch, H. Lechner

       Pages 123-129

   16. Fibrinogen/Albumin Ratio: A Useful Indicator of Hemorheological Abnormalities in Observation of Cerebrovascular Disorders

       • S. Takamatsu, K. Satoh, I. Osanai, Y. Kawamura, S. Mizuno, M. Takamatsu et al.

       Pages 130-135

At the present time several techniques are available for studying quantitatively global and regional blood flow and metabolism of the human brain. How­ ever, many scientists working in the clinical and research field who would like to use these tools for their investigations may be less familiar with the indi­ cations and limitations of the individual methods. The rapid development of both modern imaging techniques and new tracers may have led to some con­ fusion in answering the question as to which method is appropriate to solve the diagnostic problem of an individuum with brain disease. Scepticism and ignorance as to the methods to be used as tools in differential diagnosis of brain disorders may have prevented their widespread introduction into clinical practice. Thus, the significance of circulatory and metabolic parameters involved in the majority of diseases of the central nervous system may have been overlooked. The contributions compiled in this book describe in detail the individual techniques, outline their indications and limitations and deal in particular with newer methods such as the atraumatic 133Xe technique, stable xenon tomogra­ phy, three-dimensional techniques such as 133Xe single photon emission tomog­ raphy and N-isopropyl-P23-iodoamphetamine. Positron emission tomography studies provide information on function and metabolism, particularly that of oxygen and glucose, in regional brain areas of interest. Nuclear magnetic reso­ nance may be a promising method for studying metabolic parameters; however, accurate circulation measurements can not be performed at present.

• Metabolism
• Nervous System
• brain
• central nervous system
• positron emission tomography (PET)
• tomography
• trauma

• Abteilung Neurologie, Universitäts-Nervenklinik und Poliklinik, Bonn 1, Germany

  Alexander Hartmann

• Institut für Pathochemie und Allgemeine Neurochemie im Zentrum Pathologie der Universität, Heidelberg 1, Germany

  Siegfried Hoyer

Policies and ethics