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Leukemia

Report of the Dahlem Workshop on Leukemia Berlin 1983, November 13–18

  • Conference proceedings
  • © 1985

Overview

Editors:
  1. I. L. Weissman

    1. Dept. of Pathology, Stanford University School of Medicine, Stanford, USA

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Part of the book series: Dahlem Workshop Report (DAHLEM, volume 30)

Part of the book sub series: Life Sciences Research Report (DAHLEM LIFE)

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Table of contents (19 papers)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  2. Introduction

    • I. L. Weissman
    Pages 1-3

  3. Specificity of Hemopoietic Growth Factors

    • N. N. Iscove
    Pages 5-20

  4. T Cell Proliferation and Differentiation

    • W. Haas, H. von Boehmer
    Pages 21-30

  5. Regulatory Defects in Leukemia: In Vitro Analysis

    • M. A. S. Moore
    Pages 31-67

  6. Induction of B Cell Proliferation and Differentiation

    • W. E. Paul
    Pages 69-82

  7. Lymphoid Tumor Stem Cells and Their Regulation

    • R. G. Lynch
    Pages 83-94

  8. Phenotypic Heterogeneity and the Origins of Lymphoid Malignancy in Man: Biological and Clinical Implications

    • M. F. Greaves
    Pages 95-110

  9. Differentiation of T Lymphocytes

    • J. J. T. Owen
    Pages 111-130

  10. Effects of Acute Leukemia Viruses on the Differentiation of Hematopoietic Cells

    • T. Graf
    Pages 131-145

  11. Multiple Mechanisms of Oncogene Activation in Viral and Nonviral Neoplasia

    • W. S. Hayward
    Pages 147-162

  12. Oncogenes of Avian Leukemia Viruses

    • M. J. Hayman
    Pages 163-178

  13. Significance of Chromosome Rearrangements in Leukemia and Lymphoma

    • J. D. Rowley
    Pages 179-202

  14. Tracing Development and Cell Lineages in Human Hemopoietic Neoplasia

    • P. J. Fialkow, J. W. Singer
    Pages 203-222

  15. The Preleukemic State in Virus-induced Leukemia

    • M. Essex
    Pages 223-234

  16. The Receptor-mediated Leukemogenesis Hypothesis: A Model of Retroviral Oncogenesis by Viral Stimulation of Cell-surface Receptors

    • I. L. Weissman, M. S. McGrath, G. Tamura
    Pages 235-250

  17. Regulation of Hematopoietic Differentiation and Its Disruption Group Report

    • C. G. Fathman, A. Ganser, N. N. Iscove, M. Karpowicz, T. Kishimoto, E. Klein et al.
    Pages 251-262

  18. Problems in Differentiation Pathways and Cellular Targets for Leukemogens Group Report

    • D. Boettiger, M. D. Cooper, T. Graf, M. F. Greaves, A. U. Harlozinska-Szmyrka, R. Jaenisch et al.
    Pages 263-274

  19. Genes and Viruses Able to Transform Hematopoietic Cells Group Report

    • P. K. Vogt, K. Bister, A. L. Burny, C. M. Croce, W. A. Haseltine, M. J. Hayman et al.
    Pages 275-294

  20. Evolution of the Leukemic State Group Report

    • O. N. Witte, J. P. Allison, M. Essex, P. J. Fialkow, N. Haran-Ghera, J. C. Howard et al.
    Pages 295-300
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Keywords

About this book

and how the known vertebrate homologues of these genes are expressed normally in differentiation and proliferation pathways as well as abnormal­ ly in well-defined lymphomagenic and other oncogenic pathways. What emerged from this meeting are a better understanding of the evolution of these gene systems themselves and an elucidation of simpler systems open to more rapid genetic and molecular genetic analysis to reveal the normal functions of these genes and their gene products. Thus we sought new answers to several old questions concerning differenti­ ation, proliferation, and neoplastic transformation. We gathered together in an unusual format - that of the unique Dahlem Workshops - not just to reiterate data which has recently emerged but to think about how these findings might lead to new approaches for the understanding and therapy of the leukemias and lymphomas. We deliberately chose experts from several different disciplines, ranging from the clinicians who diag­ nose, describe, and treat these maladies, to the molecular geneticists trying to reduce the analysis of the problem to its simplest variables in the simplest systems possible.

Editors and Affiliations

  • Dept. of Pathology, Stanford University School of Medicine, Stanford, USA

    I. L. Weissman

Bibliographic Information

  • Book Title: Leukemia

  • Book Subtitle: Report of the Dahlem Workshop on Leukemia Berlin 1983, November 13–18

  • Editors: I. L. Weissman

  • Series Title: Dahlem Workshop Report

  • DOI: https://doi.org/10.1007/978-3-642-69722-7

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Dr. S. Bernhard, Dahlem Konferenzen, Berlin 1985

  • Softcover ISBN: 978-3-642-69724-1Published: 20 November 2011

  • eBook ISBN: 978-3-642-69722-7Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: X, 318

  • Topics: Oncology

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