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Toxicology of Inhaled Materials

General Principles of Inhalation Toxicology

  • Book
  • © 1985

Overview

Editors:
  1. Hanspeter Witschi

    1. Toxicology, Biology Division, Oak Ridge National Laboratory, Oak Ridge, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Joseph D. Brain

    1. Department of Environmental Science and Physiology, Harvard University School of Public Health, Boston, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 75)

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Table of contents (16 chapters)

  1. Front Matter

    Pages I-XVII
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  2. Exposure Techniques

    1. Front Matter

      Pages 1-1
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    2. The Design and Operation of Systems for Inhalation Exposure of Animals

      • R. T. Drew
      Pages 3-22

    3. Gases and Vapors: Generation and Analysis

      • M. Lippmann
      Pages 23-56

    4. Determination of Retained Lung Dose

      • P. A. Valberg
      Pages 57-91

  3. General Assessment of Toxic Effects

    1. Front Matter

      Pages 93-93
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    2. Animal Models

      • P. J. Hakkinen, H. P. Witschi
      Pages 95-114

    3. Epidemiologic Studies in Human Populations

      • Margaret R. Becklake
      Pages 115-147

    4. The Isolated Perfused Lung

      • A. B. Fisher
      Pages 149-179

    5. Pulmonary Cell and Tissue Cultures

      • B. T. Smith
      Pages 181-201

    6. Bronchoalveolar Lavage

      • J. D. Brain, Barbara D. Beck
      Pages 203-226

  4. Morphologic Techniques

    1. Front Matter

      Pages 227-227
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    2. Morphological Methods for Gross and Microscopic Pathology

      • D. L. Dungworth, W. S. Tyler, C. E. Plopper
      Pages 229-258

    3. Morphometry of the Alveolar Region of the Lung

      • K. E. Pinkerton, J. D. Crapo
      Pages 259-285

  5. Biological and Biochemical Analysis

    1. Front Matter

      Pages 287-287
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    2. Cellular Kinetics of the Lung

      • I. Y. R. Adamson
      Pages 289-317

    3. Mucociliary Clearance and Mucus Secretion in the Lung

      • Jennifer M. Sturgess
      Pages 319-367

    4. General Enzymology of the Lung

      • M. G. Mustafa
      Pages 369-419

    5. The Pulmonary Mixed-Function Oxidase System

      • T. E. Gram
      Pages 421-470

    6. The Surfactant System of the Lung

      • S. A. Rooney
      Pages 471-502
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Keywords

About this book

This book deals with the methods and scientific basis of inhalation toxicology. It describes devices and facilities needed to expose animals to inhaled particles and gases as well as approaches to estimating or measuring the fraction of the inhaled material that is retained in the respiratory tract. The book then reviews the evergrowing repertoire of techniques that can be used to measure the responses elicited by the exposure. Quantitative and qualitative anatomical, physiological, and biochemical strategies are discussed in detail. We believe that the toxicology of inhaled materials is an important and timely topic for several'reasons. During the past decade, morbidity and mortality attributable to cardiovascular disease have significantly decreased. Progress in combatting cancer, the second most important cause of death, has been slower, and lung cancer actually became the leading cause of death in men and the second leading cause of cancer death in women. In addition, the incidence of non-neo­ plastic respiratory diseases such as emphysema, fibrosis, and chronic bronchitis has increased the past decade. In the United States, the National Institutes of Health (NIH) has recently reported that chronic obstructive pulmonary disease affects nearly 10 miliion persons and accounts for 59,000 deaths yearly; indeed, it ranks as the fifth leading cause of death. Because the incidence is increasing, the NIH estimates that it may become the nation's fourth or even third leading cause of death by the year 2000.

Editors and Affiliations

  • Toxicology, Biology Division, Oak Ridge National Laboratory, Oak Ridge, USA

    Hanspeter Witschi

  • Department of Environmental Science and Physiology, Harvard University School of Public Health, Boston, USA

    Joseph D. Brain

Bibliographic Information

  • Book Title: Toxicology of Inhaled Materials

  • Book Subtitle: General Principles of Inhalation Toxicology

  • Editors: Hanspeter Witschi, Joseph D. Brain

  • Series Title: Handbook of Experimental Pharmacology

  • DOI: https://doi.org/10.1007/978-3-642-69521-6

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1985

  • Softcover ISBN: 978-3-642-69523-0Published: 11 January 2012

  • eBook ISBN: 978-3-642-69521-6Published: 06 December 2012

  • Series ISSN: 0171-2004

  • Series E-ISSN: 1865-0325

  • Edition Number: 1

  • Number of Pages: XVIII, 556

  • Topics: Pharmacology/Toxicology, Anesthesiology, Pharmacy

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