Overview
- Editors:
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Tihamér Z. Csáky
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Department of Pharmacology, University of Missouri-Columbia School of Medicine, Columbia, USA
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Table of contents (14 chapters)
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Front Matter
Pages I-XVIII
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- A. M. Ugolev, N. N. Iezuitova, L. F. Smirnova
Pages 31-117
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- A. B. R. Thomson, J. M. Dietschy
Pages 165-269
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- J. S. McKay, S. Hughes, L. A. Turnberg
Pages 381-390
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- K. J. Moriarty, A. M. Dawson
Pages 509-533
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- K. Ewe, R. Wanitschke, M. Staritz
Pages 535-571
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Back Matter
Pages 573-592
About this book
The intestine, particularly the small bowel, represents a large surface (in the adult 2 human approximately 200 m ) through which the body is exposed to its environ ment. A vigorous substrate exchange takes place across this large surface: nutrients and xenobiotics are absorbed from the lumen into the bloodstream or the lymph, and simultaneously, the same types of substrate pass back into the lumen. The luminal surface of the intestine is lined with a "leaky" epithelium, thus the passage of the substrates, in either direction, proceeds via both transcellular and intercellular routes. Simple and carrier-mediated diffusion, active transport, pinocytosis, phagocytosis and persorption are all involved in this passage across the intestinal wall. The term "intestinal permeation" refers to the process of passage of various substances across the gut wall, either from the lumen into the blood or lymph, or in the opposite direction. "Permeability" is the condition of the gut which governs the rate of this complex two-way passage. The pharmacologist's interest in the problem of intestinal permeation is twofold: on the one hand, this process determines the bioavailability of drugs and contributes significantly to the pharmacokinetics and toxicokinetics of xeno biotics; on the other hand, the pharmacodynamic effects of many drugs are manifested in a signigicant alteration of the physiological process of intestinal permeation.
Editors and Affiliations
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Department of Pharmacology, University of Missouri-Columbia School of Medicine, Columbia, USA
Tihamér Z. Csáky
