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Antitumor Drug Resistance

  • Book
  • © 1984

Overview

Editors:
  1. Brian W. Fox

    1. Paterson Laboratories, Christie Hospital and Holt Radium Institute, Withington, Manchester, UK

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    You can also search for this editor in PubMed   Google Scholar

  2. Margaret Fox

    1. Paterson Laboratories, Christie Hospital and Holt Radium Institute, Withington, Manchester, UK

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 72)

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Table of contents (24 chapters)

  1. Front Matter

    Pages I-XXV
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  2. Concepts of Drug Resistance

    1. Front Matter

      Pages 1-1
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    2. Clinical Setting

      • J. M. Whitehouse
      Pages 3-21

    3. Experimental Setting

      • J. F. Henderson
      Pages 23-36

  3. Modification of Host-Tumor Interaction

    1. Front Matter

      Pages 37-37
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    2. Drug Disposition and Pharmacology

      • J. G. McVie
      Pages 39-66

    3. Immunological Changes

      • H. Fuji
      Pages 67-87

    4. The Molecular Basis of Genetically Acquired Resistance to Purine Analogues in Cultured Mammalian Cells

      • J. Brennand, C. T. Caskey
      Pages 89-98

  4. Cellular Aspects

    1. Front Matter

      Pages 99-99
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    2. Cell Cycle Perturbation Effects

      • B. Drewinko, B. Barlogie
      Pages 101-141

    3. Tumour Resistance and the Phenomenon of Inflammatory-Cell Infiltration

      • M. Moore
      Pages 143-185

    4. Flow Cytometric Methods for Studying Enzyme Activity in Populations of Individual Cells

      • J. V. Watson
      Pages 187-203

    5. Chromosome Studies

      • D. Scott
      Pages 205-239

    6. Alterations of Drug Transport

      • G. J. Goldenberg, A. Begleiter
      Pages 241-298

    7. Cell Hybridisation

      • J. M. Boyle
      Pages 299-332

  5. Modification of Tumor Biochemistry

    1. Front Matter

      Pages 333-333
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    2. Drug Resistance and DNA Repair

      • M. Fox
      Pages 335-369

    3. Cyclic AMP and Prostaglandins

      • M. J. Tisdale
      Pages 371-389

    4. Properties of Mitochondria

      • A. K. Belousova
      Pages 391-402

    5. Mechanism of “Resistance” Towards Specific Drug Groups

      • T. A. Connors
      Pages 403-424
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Keywords

About this book

The study of tumour resistance to anticancer drugs has been the subject of many publications since the initial discovery of the phenomenon by J. H. Burchenal and colleagues in 1950. Many papers have been published since then reporting development of resistance to most of the well-known anticancer agents in many different animal tumour systems, both in vivo and in vitro. Many different mechanisms of resistance have been described, and it is clear that the tumour cell has a wide diversity of options in overcoming the cell-killing activity of these agents. Definition of the magnitude of the phenomenon in the clinic is, however, much more problematical, and it is with this in mind that the initial chapter, seeks to out­ line the problem as the clinicians see it. It appears that the phenomenon of true resistance to a drug, as the biochemist would recognise it, is an important cause of the failure which clinicians experience in treating the disease. The extent of the contribution of this phenomenon to the failure of treatment cannot easily be evaluated at the present time, but it is hoped that the development and application of new and more sophisticated techniques for the analysis of cellular sub­ populations may help to give a more exact estimate and to shed some light on the causes of failure of many of the present therapeutic techniques.

Editors and Affiliations

  • Paterson Laboratories, Christie Hospital and Holt Radium Institute, Withington, Manchester, UK

    Brian W. Fox, Margaret Fox

Bibliographic Information

  • Book Title: Antitumor Drug Resistance

  • Editors: Brian W. Fox, Margaret Fox

  • Series Title: Handbook of Experimental Pharmacology

  • DOI: https://doi.org/10.1007/978-3-642-69490-5

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1984

  • Softcover ISBN: 978-3-642-69492-9Published: 07 December 2011

  • eBook ISBN: 978-3-642-69490-5Published: 06 December 2012

  • Series ISSN: 0171-2004

  • Series E-ISSN: 1865-0325

  • Edition Number: 1

  • Number of Pages: XXV, 738

  • Topics: Pharmacology/Toxicology, Oncology, Pharmacy

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