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The Molecular Biology of Adenoviruses I

30 Years of Adenovirus Research 1953–1983

  • Book
  • © 1983

Overview

Editors:
  1. Walter Doerfler

    1. Institut für Genetik, Universität zu Köln, Köln 41, Germany

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Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 109)

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Table of contents (9 chapters)

  1. Front Matter

    Pages I-XII
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  2. Structure and Assembly of Adenoviruses

    • Lennart Philipson
    Pages 1-52

  3. The Mechanism of Adenovirus DNA Replication and the Characterization of Replication Proteins

    • John S. Sussenbach, Peter C. van der Vliet
    Pages 53-73

  4. The Origin of Adenovirus DNA Replication

    • Fuyuhiko Tamanoi, Bruce W. Stillman
    Pages 75-87

  5. A New Mechanism for the Initiation of Replication of Φ29 and Adenovirus DNA:Priming by the Terminal Protein

    • Margarita Salas
    Pages 89-106

  6. The Messenger RNAs from the Transforming Region of Human Adenoviruses

    • Ulf Pettersson, Anders Virtanen, Michel Perricaudet, Göran Akusjärvi
    Pages 107-123

  7. In Vitro Transcription of Adenovirus Genes

    • Roberto Weinmann, Steven Ackerman, David Bunick, Michael Concino, Ruben Zandomeni
    Pages 125-145

  8. Adenovirus Early Gene Regulation and the Adeno–associated Virus Helper Effect

    • William D. Richardson, Heiner Westphal
    Pages 147-165

  9. Antibodies to Synthetic Peptides Targeted to the Transforming Genes of Human Adenoviruses: An Approach to Understanding Early Viral Gene Function

    • Maurice Green, Karl H. Brackmann, Lynne A. Lucher, Janey S. Symington
    Pages 167-192

  10. On the Mechanism of Recombination Between Adenoviral and Cellular DNAs: The Structure of Junction Sites

    • W. Doerfler, R. Gahlmann, S. Stabel, R. Deuring, U. Lichtenberg, M. Schulz et al.
    Pages 193-228

  11. Back Matter

    Pages 229-234
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Keywords

About this book

A puzzling epidemiological problem was the driving force behind the discovery of human adenoviruses by Wallace Rowe and his colleagues 30 years ago. The de­ velopment of a plaque assay for poliomyelitis virus in 1953 led us to the threshold of quantitative virology, and in the same year the double-helical structure of DNA was discovered and became a cornerstone of mo­ lecular biology. The potential of adenoviruses as research tools in the molecular and cellular biology of eukaryotic cells was recognized as early as the late 1950s and early 1960s by several investigators. Structural and biochemical stu­ dies dominated the early years. In 1962, some of the adenoviruses were the first human viruses shown to be oncogenic in experimental animals. Thus adenovirology offered the investigator the entire gamut of host cell interactions, productive and abortive, as well as trans­ formed and tumor cell systems. The possibilities that adenoviruses afforded for the study of the molecular biology and genetics of eukaryotic cells were fully rea­ lized in the late 1960s and the 1970s.

Editors and Affiliations

  • Institut für Genetik, Universität zu Köln, Köln 41, Germany

    Walter Doerfler

Bibliographic Information

  • Book Title: The Molecular Biology of Adenoviruses I

  • Book Subtitle: 30 Years of Adenovirus Research 1953–1983

  • Editors: Walter Doerfler

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-69460-8

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 1983

  • Softcover ISBN: 978-3-642-69462-2Published: 07 December 2011

  • eBook ISBN: 978-3-642-69460-8Published: 06 December 2012

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: XII, 232

  • Topics: Virology, Medical Microbiology

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