Allergic Reactions to Drugs

1. Front Matter

   Pages I-XXXI

   PDF

2. General Aspects of Drug Allergies

   1. Front Matter

      Pages 1-1

      PDF

   2. Immunochemical Basis of Allergic Reactions to Drugs

      • C. H. Schneider

      Pages 3-36

   3. Chemical and Pharmaceutical Aspects of Drug Allergy

      • H. Bundgaard

      Pages 37-74

   4. Immunopathological Mechanisms and Clinical Aspects of Allergic Reactions to Drugs

      • A. L. de Weck

      Pages 75-133

   5. Cutaneous Manifestations of Drug Allergy

      • K. H. Schulz

      Pages 135-162

   6. Allergy of the Respiratory Tract to Low Molecular Weight Chemical Agents

      • J. Pepys

      Pages 163-185

   7. Epidemiology of Drug Allergy: Drug Monitoring

      • R. Hoigné, F. Stocker, P. Middleton

      Pages 187-205

   8. Diagnostic Procedures in Drug Allergy

      • J.-P. Girard, S. Zawodnik

      Pages 207-225

   9. Prevention and Treatment of Drug Allergies

      • A. L. De Weck

      Pages 227-240

3. Allergic Reactions to Specific Drugs

   1. Front Matter

      Pages 241-241

      PDF

   2. Major Drugs Acting on the Central Nervous System

      • C. W. Parker

      Pages 243-258

   3. General and Local Anaesthetics

      • E. S. K. Assem

      Pages 259-275

   4. Analgesics and Nonsteroidal Anti-Inflammatory Drugs

      • A. Szczeklik

      Pages 277-298

   5. Neuromuscular Blocking Drugs

      • E. S. K. Assem

      Pages 299-312

   6. Drugs Used Topically

      • K. E. Andersen, H. I. Maibach

      Pages 313-377

   7. Antihistamines

      • A. A. Fisher

      Pages 379-390

   8. Drugs Acting on the Cardiovascular System

      • H. E. Amos

      Pages 391-422

   9. Penicillins and Cephalosporins

      • A. L. de Weck

      Pages 423-482

   10. Other Antibiotics

       • D. Kraft

       Pages 483-520

According to most studies, allergic reactions represent 35%-50% of all untoward reactions to drugs, yet the pharmacological literature concerning the clinical aspects, diagnosis, and pathophysiological mechanisms of drug allergy is markedly less extensive than reports dealing with the toxicological or pharmacological effects of drugs. The main reasons for this state of affairs may be on the one hand that until a few years ago the pathophysiological mechanisms of the various types of allergic reactions were not well understood, and on the other hand that objective diagnosis of a drug allergy is still fraught with serious difficulties. Drug allergy is still an unpopular topic for most allergologists and pharmacologists; this is reflected by the fact that despite their frequency, allergic reactions to drugs still occupy a relatively small proportion of space in most pharmacology handbooks and in classical books devoted to the side effects of drugs. There has recently been considerable progress in research into the immunologi­ cal and pathophysiological events occurring in allergic reactions, and on that basis investigations of various drug allergies have also yield~d new objective findings. Consequently, it was natural to attempt a review of the most frequent and important drug allergies in the form of a handbook. We originally intended to present a comprehensive review of all drug allergies, but the realization of this goal soon became more difficult than we had at first imagined.

• Acridin
• Aldehyde
• Chloramphenicol
• Histamin
• Hormone
• Insulin
• Nicotinamid
• Phenothiazine
• Vitamin A
• Vitamin B2
• Vitamin D
• Vitamin E
• allergy
• drug
• pharmacology

• Institut für klinische Immunologie, Inselspital, Bern, Switzerland

  Alain L. Weck

• Department of Pharmaceutical Chemistry AD, The Royal Danish School of Pharmacy, Copenhagen, Denmark

  Hans Bundgaard

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