Toxicology in the Use, Misuse, and Abuse of Food, Drugs, and Chemicals

1. Front Matter

   Pages I-X

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2. Effects of Foreign Substances on Blood

   1. Front Matter

      Pages 1-1

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   2. The Red Cell as a Sensitive Target for Activated Toxic Arylamines

      • P. Eyer

      Pages 3-12

   3. Chemotherapy Related Leukemogenesis

      • Dina Meytes, B. Ramot

      Pages 13-20

   4. Drug Vulnerability of Peripheral Blood Platelets

      • M. Djaldetti

      Pages 21-32

   5. Drug Toxicity on Thrombocyte Receptors

      • A. Rotman

      Pages 33-36

   6. Effects of Radiographic Contrast Media on the Serum Complement System

      • P. Tirone, E. Boldrini

      Pages 37-41

   7. An Hypothesis for the Induction of Leukemia by Benzene

      • L. Braier

      Pages 42-46

   8. Toxic Effects of Hyperbaric Oxygen on the Blood

      • A. Cerrati, G. Bruno, C. Casarotto, A. Mariani, I. Raggi, A. Ronzio et al.

      Pages 47-47

   9. In Vitro Effects of Mercury on Platelet Aggregation, Thromboxane and Vascular Prostacyclin Production

      • L. Caprino, A. R. Togna, B. Cebo, N. Dolci, G. Togna

      Pages 48-51

   10. Partial Isolation and Characterisation of a Hemagglutinating Factor from Avocado Seed

       • Y. Yaakobovich, I. Neeman

       Pages 52-57

3. Drugs of Abuse — With Special Reference to Marijuana and Phencyclidine

   1. Front Matter

      Pages 59-59

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   2. Guide to the Analysis of Phencyclidine and its Metabolites in Biological Material

      • J.-E. Lindgren, B. Holmstedt

      Pages 61-73

   3. Quantification of Δ ¹-Tetrahydrocannabinol in Tissues and Body Fluids

      • J.-E. Lindgren

      Pages 74-80

   4. Characterization of the Interaction of Phencyclidine and its Derivatives with the Ionic Channel of the Nicotinic Receptor

      • R. Haring, S. Theomy, A. Kalir, M. Sokolovsky

      Pages 81-90

   5. Models to Predict Cannabinoid-Induced Disturbances

      • H. Edery

      Pages 91-103

   6. Cannabinoid Drugs

      • R. Mechoulam, N. Lander, S. Dikstein, B. Shalita

      Pages 104-104

   7. A Novel Non-Centrifugation Radioimmunoassay for Cannabinoids

      • M. Cais, S. Dani, M. Shimoni

      Pages 105-113

   8. Behavioral Changes Indicative of Cannabinoids or Phencyclidine Intoxication in Man

      • E. Malizia, S. Borgo, G. Andreucci, M. Smeriglio

      Pages 114-114

   9. Effect of Cannabis on Enzyme Induction by Phenobarbital

      • P. Sanz, P. Villar, M. Repetto

      Pages 115-120

Many chemotherapeutic agents introduced for use in humans are carcinogenic in laboratory animals (Conklin et al. 1965; Shimkin et al. 1966; Griswold et al. 1968; Harris 1976). However, initially their beneficial effect in disseminated cancer was of such short duration that the inevitable death of the patient from his primary disease precluded any clinical manifestation of the carcinogenic potential. During the last decade, chemotherapy has radically changed the outlook for many patients with cancer. Combinations of drugs, administered as the primary treatment, have resulted in high rates of cure in patients with disseminated malignancies, such as stage IV Hodgkin's disease or childhood acute lymphocytic leukemia. In other disseminated forms of neoplasia, induction of a remission, a substantial palliation and a prolongation of survival have been achieved. In many instances of localised disease, where surgery with or without radiotherapy are the primary form of treatment, anticancer drugs have been used with success as adjuvant therapy for distant microscopic disease. With these spectacular achievements, secondary malignancies, in particular acute non-lymphocytic leukemia (ANLL), has become of major concern. Incidence Acute leukemia is the most frequent form of secondary neoplasia in patients treated for cancer (Penn 1981). In one large series, 5. 9% of all ANLL could be attributed to previous chemotherapy (Kapadia et al. 1980).

• Cannabinoid
• Ethanol
• Interferon
• Toxicology
• Toxikologie
• drugs of abuse
• marijuana
• mercury
• pesticide

• Department of Pharmacology, Trinity College, University of Dublin, Dublin 2, Ireland

  Claire M. Chambers, Philip L. Chambers

• Sackler Faculty of Medicine, and Kupat Holim — General Federation of Labour, Institute for Occupational Health, Tel Aviv University, Tel Aviv, Israel

  S. Gitter

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