Inhalation Anaesthesia Today and Tomorrow

1. Front Matter

   Pages I-XII

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2. Basics of Biotransformation

   • I. Rietbrock

   Pages 1-10

3. Hepatic Oxygenation and Fluoride Release During Halothane Anesthesia

   • L. Irestedt

   Pages 11-12

4. Current Status of Hepatotoxicity of the Halogenated Inhalation Anesthetics

   • B. R. Brown Jr.

   Pages 13-18

5. Present Status of Chronic Exposure to Trace Concentrations of Volatile Anaesthetics

   • H. O. Stoeckel, P. M. Lauven

   Pages 19-25

6. Aspects of Possible Health Hazards from Traces of Waste Anaesthetic Vapours and Gases

   • K. Taeger

   Pages 27-29

7. The Kinetics of the Uptake and Elimination of Halothane and Enflurane

   • H. Schmidt, R. Dudziak

   Pages 31-44

8. Molecular Basis for Unitary Theories of Inhalation Anaesthesia

   • J. R. Trudell

   Pages 45-52

9. Clinical Implications of the Pharmacodynamics of Inhalation Anaesthetics

   • G. Torri, C. Martani, V. Perotti

   Pages 53-58

10. Advances in Cardiovascular Pathophysiology

    • B. E. Strauer

    Pages 59-77

11. Anaesthesia in Coronary Heart Disease

    • G. Smith

    Pages 79-85

12. The Anaesthetic Management of Coronary and Cardiac Surgery

    • D. G. Lappas

    Pages 87-95

13. Influence of Inhalation Anaesthetics on the Autonomic Nervous System

    • M. Göthert

    Pages 97-108

14. Interactions of Cardiovascular Drugs with Inhalational Anaesthetics

    • P. Foëx, G. R. Cutfield, C. M. Francis

    Pages 109-128

15. Microcirculatory Effects of Halothane and Enflurane

    • N. Franke, B. Endrich, K. Meßmer

    Pages 129-135

16. Distribution of EEG Frequency Bands as Revealed by Factor Analysis During Anaesthesia with Halothane and Enflurane

    • H. Schwilden, H. Stoeckel

    Pages 137-146

17. The Effects of Inhalational Anaesthetics on the Brain

    • P. A. Steen

    Pages 147-150

18. The Effects of Inhalation Anaesthetics on Intracranial Pressure

    • G. Cunitz

    Pages 151-157

19. The Effects of Inhalation Anaesthetic Agents on Liver Blood Flow and Hepatic Oxygen Consumption

    • W. Fitch, R. L. Hughes, I. Thomson, D. Campbell

    Pages 159-163

20. Total Effect of Repeated Anaesthetics on Liver Function

    • J. P. H. Fee, G. W. Black, J. W. Dundee

    Pages 165-166

In clinical anaesthesiology the inhalation anaesthetics halothane (fluothane), enflurane and - in recent times - forane got a renaissance in clinical application. The reasons are not only the ad­ vantages of volatile anaesthetics, but also the fact that the investi­ gations of pharmacodynamics and pharmacokinetics of Lv. narcot­ ics showed negative aspects. It was the aim of the organizers of the symposium to give a survey of the present state of knowledge on inhalation anaesthetics, which is as up-to-date, critical as well as detailed as possible. Furthermore it was the intention to evaluate the recent advances made in the field of basic research. The first section of the symposium in particular enters into the question of the toxicity of volatile anaesthetics as well as their mechanisms of action. In a second main part the influences on cardiovascular system and on microcirculation are discussed. Apart from the extensive discussion of the advances in knowledge in the field of cardiovascular pathophysiology, the focal point of the contribut­ ions is made up of those with anaesthesia in coronary heart disease and cardiac insufficieny as well as the contribution on interactions of inhalation anaesthetics with cardiovascular drugs. In the third and fourth section the influences of volatile anaesthetics on cerebral, hepatic, renal and pulmonary function are dealt with as well as questions concerning the clinical application. Particular attention is given to the important problems of indicat­ ion in patients belonging to the extreme age groups.

• Anaesthesia
• Inhalation
• Inhalationsnarkotikum
• pathophysiology
• surgery

• Klinikum Großhadern Institut für Anaesthesiologie, Ludwig-Maximilians-Universität München, München 70, Federal Republic of Germany

  K. Peter, F. Jesch

Policies and ethics