Pyretics and Antipyretics

1. Front Matter

   Pages I-XXIV

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2. Body Heat

   • A. S. Milton

   Pages 1-4

3. Fever and Its Role in Disease: Rationale for Antipyretics

   • N. W. Kasting, W. L. Veale, K. E. Cooper

   Pages 5-24

4. Thermoregulation: Its Change During Infection with Endotoxin-Producing Micro-organisms

   • J. Bligh

   Pages 25-71

5. Exogenous Pyrogens

   • C. A. Dinarello, S. M. Wolff

   Pages 73-112

6. Endogenous Pyrogens

   • G. W. Gander

   Pages 113-123

7. Role of Central Neurotransmitters in Fever

   • B. Cox, T. F. Lee

   Pages 125-150

8. The Role of Ions in Thermoregulation and Fever

   • R. D. Myers

   Pages 151-186

9. Electrophysiology of the Anterior Hypothalamus: Thermoregulation and Fever

   • J. S. Eisenman

   Pages 187-217

10. Cyclic Nucleotides and Fever

    • M. J. Dascombe

    Pages 219-255

11. Prostaglandins in Fever and the Mode of Action of Antipyretic Drugs

    • A. S. Milton

    Pages 257-303

12. Protein Synthesis and Fever

    • A. S. Milton, V. K. Sawhney

    Pages 305-315

13. The Chemistry of the Non-Steroidal Antipyretic Agents: Structure-Activity Relationships

    • D. H. Kim, C. G. Van Arman, D. Armstrong

    Pages 317-375

14. Therapeutic Agents Affecting Body Temperature

    • R. G. Pertwee

    Pages 377-435

15. Capsaicin Type Pungent Agents Producing Pyrexia

    • J. Szolcsányi

    Pages 437-478

16. The Pathophysiology of Fever in the Neonate

    • M. Székely, Z. Szélenyi

    Pages 479-528

17. The Treatment of Fever from a Clinical Viewpoint

    • C. A. Dinarello

    Pages 529-546

18. Malignant Hyperthermia: A Review

    • B. A. Britt

    Pages 547-615

19. Febrile Convulsions

    • J. B. P. Stephenson, C. Ounsted

    Pages 617-648

20. The Pyrogenic Responses of Non-mammalian Vertebrates

    • W. W. Reynolds, M. E. Casterlin

    Pages 649-668

Fever has always been recognised as the major sign of infectious disease as well as being associated with other illnesses. The suggestion of publishing a volume dedicated exclusively to the subject of fever in the Handbook of Experimental Pharmacology series was one that greatly appealed to me, and I felt very honoured when I was invited to edit it. The first ideas about this volume were conceived in the latter part of 1977 and by the middle of 1978 the first authors had been approached. As is usual with such publications, by the time the first manuscripts were beginning to arrive in the late spring of 1979 there were still a few chapters for which authors had not yet been found. Finally by the end of 1981 the volume was complete. Because of the span of time over which the chapters were written, some refer to more recent work than others; however, I do not feel that this detracts from the overall contribution of all the chapters.

• Fieber
• Fiebersenkendes Mittel
• Pyrogen
• infectious disease
• pharmacology

• Department of Pharmacology, University of Aberdeen, Marischal College, Aberdeen, Scotland, Great Britain

  Anthony S. Milton

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