Catecholamines and the Heart

1. Front Matter

   Pages I-XIX

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2. Sympathetic Nerves and Adrenergic Receptors

   1. Front Matter

      Pages IN1-IN1

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   2. Regulation of Sympathetic Outflow to the Heart

      • H. Seller, J. Czachurski, K. Dembowsky

      Pages 1-10

   3. Relationship Between Sympathetic Outflow to Muscles, Heart Rate and Plasma Noradrenaline in Man

      • B. G. Wallin

      Pages 11-18

   4. Classification and Function of Adrenoceptors

      • E. Carlsson, A. Hedberg, H. Mattsson

      Pages 19-28

   5. Role of Presynaptic and Postsynaptic Adrenoceptors in Cardiac Function

      • K. Starke, H. Majewski

      Pages 29-38

   6. Sympathetic Control of Coronary Circulation

      • E. Bassenge, J. Holtz

      Pages 39-52

   7. Identification of Cardiac Alpha-Adrenergic Receptors by Direct Binding Studies: Clinical Implications

      • L. T. Williams

      Pages 53-60

   8. Identification and Characterization of Beta-Adrenergic Receptors in Myocardium Under Normal and Pathologic Conditions

      • G. L. Stiles, R. J. Lefkowitz

      Pages 61-71

   9. Catecholamines and β-Adrenergic Receptors in the Non-ischemic Myocardium After Coronary Occlusion

      • G. Baumann, G. Riess, S. B. Felix, W. D. Erhardt, U. Loher, L. Ludwig et al.

      Pages 72-91

   10. Heart Catecholamines in Genetic Hypertension

       • J. M. Saavedra, J. Fernandez-Pardal, P. Guicheney, J. B. Furness, R. McCarty, B. Rouot et al.

       Pages 92-106

3. Biochemical and Physiological Implications of Adrenergic Receptor Stimulation

   1. Front Matter

      Pages IN2-IN2

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   2. Principles of Signal Transformations Mediated by Subtypes of Adrenergic Receptors

      • G. Schultz, K. H. Jakobs

      Pages 107-117

   3. Occurrence and Functional Significance of Cardiac Muscle Protein Kinases

      • R. Mewes, F. Hofmann

      Pages 118-127

   4. Cyclic AMP-Dependent Activation of Protein Kinases in the Myocardium

      • J. G. Dobson Jr.

      Pages 128-141

   5. Antiadrenergic Action sof Adenosine in the Heart: Possible Physiological Significance

      • J. Schrader, G. Baumann, E. Gerlach

      Pages 142-153

   6. Effects of Ionic Composition on Cardiac Sarcolemmal Adenylate Cyclase

      • L. Leclerc, P. Harris

      Pages 154-158

   7. Catecholamines and Cardiac Adenine Nucleotide Metabolism

      • H.-G. Zimmer, H. Ibel

      Pages 159-169

   8. Beta-Adrenoceptor Stimulation and Membrane Calcium Permeability

      • H. Reuter

      Pages 170-176

   9. The Problem of Catecholamine Oxygen Wasting in the Heart

      • E. O. Feigl, G. A. Rooke

      Pages 177-183

An International Symposium "Catecholamines and the Heart" was held in Munich in May 1981, which was organized in cooperation with the Council on Cardiac Metabolism of the International Society and Federation of Cardiology and with the Microcirculation Working Group of the European Society of Cardiology. It was the aim of the organizers to evaluate in this Symposium the recent advances made in the field of sympathetic control of heart function. Particular attention was given to neural sympathetic pathways, to mechanisms and consequences of adrenoceptor stimulation and blockade as well as to clinically relevant implications mainly regarding the significance of catecholamines and of adrenoceptors in various heart diseases. The broad scope was covered in 34 papers presented by physiologists, pharmacologists and cardiologists during a two day meeting which was attended by an international audience. This book includes all papers as well as the discussions following each presentation. To accomplish rapid publication the manuscripts are published as submitted by the authors. The discussions were edited making use of the written questions and answers of the discussants. The Symposium was generously sponsored by Astra Chemicals GmbH, Wedell Holstein, Germany, which thus made possible a very fruitful exchange of information, ideas and concepts between specialists in various disciplines. The organizers gratefully acknowledge this support once again and would like to thank Dr. T. Kreuzer, the representative of Astra Chemicals, for his personal engagement.

• circulation
• clinical research
• heart
• metabolism
• research

• Medizinische Abteilung, Krankenhaus Kempfenhausen der Stadt Müchen, Germany

  W. Delius

• Physiologisches Institut, Universität Müchen, Germany

  E. Gerlach

• Lehrstuhl für Pharmakologie, Universität Regensburg, Germany

  H. Grobecker

• Abteilung Innere Medizin III (Kardiologie), Medizinische Klinik der Universität Heidelberg, Germany

  W. Kübler

Policies and ethics