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Spinal Opiate Analgesia

Experimental and Clinical Studies

  • Book
  • © 1982

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Editors:
  1. Tony L. Yaksh

    1. Depts. of Neurologic Surgery and Pharmacology, Mayo Foundation, Rochester, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Hermann Müller

    1. Dept. of Anesthesiology and Intensive Care Medicine, Justus Liebig University, Giessen, Federal Republic of Germany

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

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Table of contents (26 chapters)

  1. Front Matter

    Pages I-XII
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  2. Animal Studies on the Spinal Action of Opiates in Analgesia

    • T. L. Yaksh
    Pages 1-8

  3. Theoretical Aspects and Practical Considerations Concerning Selective Opiate-Analgesia

    • H. Müller, U. Börner, M. Stoyanov, G. Hempelmann
    Pages 9-17

  4. Dangers and Complications of Intrathecal and Epidural Opiates

    • Ph. R. Bromage
    Pages 18-23

  5. Mechanism of Intrathecally Administered Morphine Analgesia

    • K. Hanaoka, M. Tagami, H. Toyooka, H. Yamamura
    Pages 24-29

  6. Actions of Epidural Morphine in Normal Human Subjects

    • T. A. Torda, D. A. Pybus, H. Liberman, M. Clark, M. Crawford
    Pages 30-32

  7. Epidural Opiate Analgesia (EOA): Compatibility of Opiates with Tissue and CSF

    • U. Börner, H. Müller, M. Stoyanov, G. Hempelmann
    Pages 33-36

  8. Epidural Morphine: A new Approach to Postoperative Analgesia in Urological Surgery

    • H. J. Birkhan, B. Rosenberg, K. Simon, B. Moskowitz
    Pages 37-39

  9. Therapeutic and Diagnostic Uses of Morphine Epidurals in the Management of Pain

    • J. M. Farcot, B. Laugner, A. Muller
    Pages 40-46

  10. Epidural Morphine for 24 Hours of Postoperative Analgesia

    • G. P. Handjis, A. Liolios, A. Anagnostakos, G. Vailas, C. E. Tsantakis
    Pages 47-50

  11. Epidural Low-Dose Morphine and Postoperative Pain: A Controlled Study

    • B. Ch. Jørgensen, H. B. Andersen, A. Engquist
    Pages 51-52

  12. A Step to Complete Pain Relief After Surgery

    • Y. Kawashima, N. Uchida, S. Kawahira, K. Meguro, T. Nampo, Y. Fujita
    Pages 53-57

  13. Peridural Bupivacaine and Morphine for Residual Pain After Peripheral Vascular Surgery

    • R. Manolescu, I. Elian, J. M. Lehmann
    Pages 58-61

  14. Postoperative Hypoalgesia by Epidural Morphine After Abdominal Surgery

    • A. Muller, A. Straja, J. P. Dupeyron, D. Franckhauser, E. Dumeny
    Pages 62-66

  15. The Perioperative Use of Epidural Opiates

    • H. Müller, U. Börner, M. Stoyanov, G. Hempelmann
    Pages 67-85

  16. Pain Relief with Morphine, Applied Intrathecally or Epidural

    • J. Sarubin, E. Gebert
    Pages 86-90

  17. The Use of Epidural Buprenorphine for the Treatment of Postoperative Pain

    • M. Rondomanska, J. de Castro, L. Lecron
    Pages 91-94

  18. Postoperative Analgesia in Cesarean Section, with Epidural Morphine

    • J. Seebacher, M. Henry, C. Leveque, Y. Darbois, P. Viars
    Pages 95-98

  19. Continuous Epidural Analgesia in the Perioperative Period

    • L. Varga
    Pages 99-102

  20. The Control of Postoperative Pain by Thoracic Fentanyl Epidural and its Effect Upon the Stress Response

    • E. A. Welchew, J. A. Thornton
    Pages 103-108
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Keywords

About this book

The recent development of the use of spinal opiates as a rational therapy for pain rests on clear and certain experimental data. We have long known the spinal cord to be a highly complex structure. Anatomical studies of the substantia gelatinosa have repeatedly demonstrated signs of massive synaptic interaction between primary afferents, descending pathways and intrinsic neurons. Yet, to date that knowledge, insofar as clinical therapy is concerned, has permitted us only to destroy certain connections within the spinal cord in the hopes that the substrate mediating pain could be anatomically differentiated from those which mediate other function. Though cordotomies are clearly effective under certain circumstances, they suffer from the fact the spinal cord is not organized in such an anatomically discrete fashion as is often times drawn in basic medical text. Rather, functions intertwine exquisitely and specific physical interventions are no more likely to produce a specific effect than smashing of the fmgertip with a hammer will produce just a loss of the fingernail. The development of specific therapies of the spinal cord has come about by our growing aware­ ness of the intricate organization of the pharmacological substrates associated with specific neural function.

Editors and Affiliations

  • Depts. of Neurologic Surgery and Pharmacology, Mayo Foundation, Rochester, USA

    Tony L. Yaksh

  • Dept. of Anesthesiology and Intensive Care Medicine, Justus Liebig University, Giessen, Federal Republic of Germany

    Hermann Müller

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