Industrial and Environmental Xenobiotics

1. Front Matter

   Pages I-XIV

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2. Metals

   1. Metabolic Factors in the Distribution and Half Time of Mercury After Exposure to Different Mercurials

      • L. Magos

      Pages 1-15

   2. Biliary Excretion of Metals

      • M. Cikrt

      Pages 17-36

   3. Effect of Short Fasts on Heavy Metal Absorption in the Rat

      • J. Quarterman, E. Morrison

      Pages 37-43

   4. Failure of Trace Element Additives to Decrease Cadmium, Mercury, and Manganese Absorption in Suckling Rats

      • I. Rabar, K. Kostial

      Pages 45-47

   5. Manganese-Induced Changes in Biotransformation Enzyme Activities in Rats

      • E. Hietanen, M. Ahotupa, J. Kilpiö, H. Savolainen

      Pages 49-58

   6. Metallothionein in Urine of Cadmium-Exposed Rats: Relation to the Cadmium Deposit and the Injury of Liver and Kidneys

      • J. M. Wisniewska-Knypl, T. Hałatek, J. Kołakowski, I. Stetkiewicz

      Pages 59-67

   7. Biological Monitoring of Exposure to Manganese by Mn Hair Content

      • V. Bencko, D. Arbetová, V. Skupeňová, A. Pápayová

      Pages 69-70

   8. Kinetics of Inhaled Aerosol [85Sr] Cl2

      • J. Halík, V. Lenger

      Pages 71-76

   9. The Effect of Cadmium on Hepatic Fatty Acid Biosynthesis in Rats

      • E. Steibert, F. Kokot

      Pages 77-81

   10. Inorganic Cations Toxicity-Application of QSAR Analysis

       • M. Tichý, Z. Roth, M. Krivucová, M. Cikrt

       Pages 83-86

   11. The Relation Between the Connectivity Index of Some Cations and Their Toxicity

       • J. Sýkora, V. Eybl

       Pages 87-91

   12. Human Erythrocyte Membrane Proteins: Interaction with 99 Molybdenum

       • M. Kselikova, J. Lener, T. Marik, B. Bibr

       Pages 93-95

3. Organic Chemicals

   1. Potentiation of Haloalkane-Induced Hepatotoxicity and Nephrotoxicity: Role of Biotransformation

      • G. L. Plaa

      Pages 96-110

   2. Pulmonary Toxicity of Carbon Tetrachloride

      • M. R. Boyd

      Pages 111-119

   3. Rat Liver and Kidney Gluconeogenesis After Acute Intoxication with Carbon Tetrachloride

      • P. Hortelano, M. J. Faus, F. Sanchez-Medina

      Pages 121-131

   4. Evaluation of Hepatic Mixed Function Oxidase (MFO) Systems After Administration of Allylisopropylacetamide CC14 CS2 or Polyriboinosinic Acid · Polyribocytidylic Acid to Mice

      • G. J. Mannering, L. B. Deloria, V. S. Abbott

      Pages 133-146

   5. Molecular Mechanism of the Xenobiotica Metabolizing Enzyme Cytochrome P-450

      • H. Rein, O. Ristau, K. Ruckpaul

      Pages 147-159

   6. Metabolic Activation and Pharmacokinetics in Hazard Assessment of Halogenated Ethylenes

      • H. M. Bolt, J. G. Filser, R. J. Laib

      Pages 161-167

   7. The Involvement of Bay-Region and Non-Bay-Region Diol-epoxides in the in Vivo Binding of Benz(a)anthrocene Derivatives to DNA

      • P. Vigny, M. Kindts, C. S. Cooper, P. L. Grover, P. Sims

      Pages 169-179

The book you are just going to read represents the greater part of the papers presented at the International Conference on Industrial and En­ vironmental Xenobiotics, held in Prague, 1980, and some contributions by those who could not come. The first aim of the meeting was to fol­ low the tradition set up by the first conference in 1977. Again, we in­ vited biochemists, pharmacologists, and toxicologists from both East and West, who were involved in the study of disposition, biotransforma­ tion, and toxicity of important kinds of industrial and environmental pollutants, to promote the exchange of ideas and opinions on priorities in this area of the study of human environment. The invited contributions offer an excellent survey of and pro­ found insight into specific areas of toxicology and disposition of metals and organic chemicals, and the series of papers on specific subjects bring fresh information on the biotransformation and mechanisms of toxic action of several industrially important solvents tmd monomers of plastics. Rather than from the Preface, the reader should seek guidance from the Index, which clearly shows the overlapping of this area of toxicology with the latest results in biochemistry. We gratefully acknowledge the understanding, care, and preciSion of the publisher that made this book possible. The Editors Contents Metals Metabolic Factors in the Distribution and Half Time of Mercury After Exposure to Different Mercurials 1. Magos. With 1 Figure . . . . . . . . . . . . . . . . . . .. . . . 1 . . . . . Biliary Excretion of Metals M. Cikrt. With 9 Figures. . . . . . . . . . . . . . . . . . . .. . . 17 . . . . .

• Biotransformation
• Pharmakologie
• Schwermetallbelastung
• Toxikologie
• mercury

• Institute of Hygiene and Epidemiology, Prague 10, Czechoslovakia

  Ivan Gut, Miroslav Cikrt

• Faculté des études supérieures, Université de Montréal, Montréal, Canada

  Gabriel L. Plaa

Policies and ethics