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Cardiac Glycosides

Part II: Pharmacokinetics and Clinical Pharmacology

  • Book
  • © 1981

Overview

Editors:
  1. Kurt Greeff

    1. Instituts für Pharmakologie, Universität Düsseldorf, Düsseldorf, Deutschland

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Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 56 / 2)

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Table of contents (15 chapters)

  1. Front Matter

    Pages I-XXI
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  2. Pharmacokinetics — Distribution, Metabolism, and Elimination

    1. Front Matter

      Pages 1-1
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    2. Pharmacokinetics of Digitoxin

      • Liv Storstein
      Pages 3-30

    3. Pharmacokinetics of Digoxin and Derivatives

      • N. Rietbrock, B. G. Woodcock
      Pages 31-56

    4. Pharmacokinetics of Strophanthus Glycosides

      • K. Greeff, K. E. Wirth
      Pages 57-85

    5. Pharmacokinetics of Squill Glycosides

      • K.-E. Andersson, B. Bergdahl
      Pages 87-94

  3. Pharmacokinetics — Additional Pharmacokinetic Parameters of Cardiac Glycosides

    1. Front Matter

      Pages n3-n3
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    2. Plasma Protein Binding of Cardiac Glycosides

      • J. Krieglstein
      Pages 95-104

    3. Intestinal Absorption and Secretion of Cardiac Glycosides

      • F. Lauterbach
      Pages 105-139

    4. Cardiac Uptake and Binding of Cardiac Glycosides

      • S. Dutta
      Pages 141-168

    5. Bioavailability of Cardiac Glycosides

      • T. R. D. Shaw
      Pages 169-187

    6. Pharmaceutical Quality Control Standards for Cardiac Glycosides

      • G. A. Stewart
      Pages 189-203

  5. Back Matter

    Pages 337-396
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Keywords

About this book

The pharmacokinetics of digitalis glycosides have been the subject of extensive re­ view (IISALO, 1977; ARONSON, 1980; PERRIER et ai., 1977). Research on glycoside kinetics has progressed at a rapid pace, requiring continuing reevaluation of the state of our understanding of this problem. The present article focuses on the effect of disease states (renal, gastrointestinal, thyroid, and cardiac) on the absorption, distribution, and clearance of a number of digitalis glycosides. Evidence is critically reviewed, and interpreted with respect to possible clinical implications. A. Renal Insufficiency I. Strophanthin Strophanthin disposition in renal failure has been evaluated in only two studies. KRAMER et ai. (1970) determined an elimination half-life of 14 h in normals as com­ pared to 60 h in anuric patients. Similar results were reported by BRASS and Pm­ LIPPS (1970) using tritiated strophanthin. They found a half-life value of 18 h in healthy individuals as compared to 68 h in anuric patients. The findings clearly in­ dicate that the elimination half-life of strophanthin is prolonged in renal failure.

Editors and Affiliations

  • Instituts für Pharmakologie, Universität Düsseldorf, Düsseldorf, Deutschland

    Kurt Greeff

Bibliographic Information

  • Book Title: Cardiac Glycosides

  • Book Subtitle: Part II: Pharmacokinetics and Clinical Pharmacology

  • Editors: Kurt Greeff

  • Series Title: Handbook of Experimental Pharmacology

  • DOI: https://doi.org/10.1007/978-3-642-68166-0

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1981

  • Softcover ISBN: 978-3-642-68168-4Published: 07 December 2011

  • eBook ISBN: 978-3-642-68166-0Published: 06 December 2012

  • Series ISSN: 0171-2004

  • Series E-ISSN: 1865-0325

  • Edition Number: 1

  • Number of Pages: XXI, 394

  • Topics: Pharmacology/Toxicology, Pharmacy

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