Cardiac Glycosides

1. Front Matter

   Pages I-XXIV

   PDF

2. Introduction and Remarks on the History of Cardiac Glycosides

   1. Introduction and Remarks on the History of Cardiac Glycosides

      • K. Greeff, H. Schadewaldt

      Pages 1-12

3. Chemistry and Structure-Activity Relationships of Cardioactive Steroids

   1. Chemistry and Structure-Activity Relationships of Cardioactive Steroids

      • T. W. Güntert, H. H. A. Linde

      Pages 13-24

4. Methods for the Determination of Cardiac Glycosides

   1. Front Matter

      Pages 25-25

      PDF

   2. Chemical and Chromatographic Methods

      • H. Flasch, W. Diembeck

      Pages 27-42

   3. Use of Radioactively Labeled Glycosides

      • H. Flasch

      Pages 43-55

   4. Radioimmunologic Methods

      • K. Stellner

      Pages 57-81

   5. ATPase for the Determination of Cardiac Glycosides

      • Ursula Gundert-Remy, Ellen Weber

      Pages 83-94

   6. Rubidium Uptake in Erythrocytes

      • G. G. Belz

      Pages 95-113

5. Biological Methods for the Evaluation of Cardiac Glycosides

   1. Front Matter

      Pages 115-115

      PDF

   2. Evaluation of Cardiac Glycosides in the Intact Animal

      • H. Bahrmann, K. Greeff

      Pages 117-152

   3. The Use of the Isolated Papillary Muscle for the Evaluation of Positive Inotropic Effects of Cardioactive Steroids

      • M. Reiter

      Pages 153-159

   4. Evaluation of Cardiac Glycosides in Isolated Heart Preparations Other than Papillary Muscle

      • K. Greeff, D. Hafner

      Pages 161-184

6. Mode of Action of Cardiac Glycosides

   1. Front Matter

      Pages 185-185

      PDF

   2. The Positive Inotropic Action of Cardiac Glycosides on Cardiac Ventricular Muscle

      • M. Reiter

      Pages 187-219

   3. Influence of Cardiac Glycosides on Electrophysiologic Processes

      • R. Weingart

      Pages 221-254

   4. Influence of Cardiac Glycosides on Myocardial Energy Metabolism

      • K. Güttler, W. Klaus

      Pages 255-285

   5. Effects of Cardiac Glycosides on Na+, K+-ATPase

      • T. Akera

      Pages 287-336

   6. Influence of Cardiac Glycosides on their Receptor

      • E. Erdmann

      Pages 337-380

   7. Stimulation and Inhibition of the Na+, K+-Pump by Cardiac Glycosides

      • T. Godfraind

      Pages 381-393

Following the monographs by STRAUB (1924) and LENDLE (1935), this is the third contribution to the "Pharmacology of Cardiac Glycosides" within the Handbook of Experimental Pharmacology, which was founded by ARTHUR HEFFTER and con­ tinued by WOLFGANG HEUBNER. Because of the need created by the length of time that had elapsed since LENDLE'S work, the editorial board requested the rapid ap­ pearance of this 56th volume, which represents current knowledge of the pharma­ cology and clinical pharmacology of cardiac glycosides. In order to avoid any delay, numerous authors were invited to contribute because shorter contributions take less time to prepare and are consequently more up-to-date. The disadvantage is that some overlap between certain chapters could not be avoided, despite the editor's efforts. Overlapping can, however, actually be useful, in that differing opinions may be provided and topical issues discussed from varying viewpoints. This re­ minds the reader that scientific horizons in medicine should often be widened or revised. I would like to thank DR. ALANNA Fox and DR. K. ANANTHARAMAN for their help and advice in the revision of certain chapters. I am also grateful to Springer­ Verlag, and particularly to MR. WINSTANLEY and MR. EMERSON, for their contribu­ tion to the completion of this volume through translation and corrections. In con­ clusion I would like to thank MRS. WALKER, MR. BISCHOFF, MRS. SEEKER, and MR. BERGSTEDT of Springer-Verlag for their helpful support.

• Drogen
• Hormone
• Lipid
• Respiration
• Steroid
• chemistry
• chromatography
• extraction
• oxygen
• pharmacokinetics
• pharmacology
• purity
• separation
• spectroscopy
• synthesis

• Instituts für Pharmakologie, Universität Düsseldorf, Düsseldorf, Germany

  Kurt Greeff

Policies and ethics