Overview
- Editors:
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J. A. Nathanson
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Neuropharmacology Research Laboratory, Departments of Neurology and Pharmacology, Harvard Medical School, Massachusetts General Hospital, Boston, USA
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J. W. Kebabian
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Biochemical Neuropharmacology Unit, NINCDS National Institutes of Health, Bethesda, USA
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Table of contents (15 chapters)
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Biochemistry of Cyclic Nucleotides
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- G. R. Revankar, R. K. Robins
Pages 17-151
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- L. Birnbaumer, R. Iyengar
Pages 153-183
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- J. P. Perkins, T. K. Harden, J. F. Harper
Pages 185-224
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- M. M. Appleman, M. A. Ariano, D. J. Takemoto, R. H. Whitson
Pages 261-300
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- W. Y. Cheung, D. R. Storm
Pages 301-323
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- C. L. Kapoor, A. L. Steiner
Pages 333-354
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Biochemistry of Protein Phosphorylation
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Front Matter
Pages 355-355
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Back Matter
Pages 535-557
About this book
The purpose of the present volume, the first of two on the pharmacology, biochemistry, and physiology of cyclic nucleotides, is to provide a comprehensive and up-to-date anthology on the nature and role of these important chemical regulators. Each of the chapters is the work of internationally known researchers who present a lucid and detailed review of their subject and not merely a single laboratory's viewpoint. The chapters emphasize critical assessments of the field rather than mere listings of experimental findings. By so doing, the contributors present the role of cyclic nucleotides in relationship to other intracellular regulators. Each chapter begins with a detailed summary to allow the reader to obtain a rapid overview of subsequent material. In addition, there are extensive bibliographies and a detailed subject index. Wherever pertinent, the chapters contain sections on drug mechanisms, physiological relevance, and disease processes. The Volume is divided into two sections, each beginning with an overview written by Professors T. W. RALL and P. GREENGARD, respectively. The first section focuses on the detailed pharmacology and chemistry of cyclic nucleotides, including their formation, degradation, measurement, and interaction with various modulatory agents, such as receptors and calcium. The second section is concerned with the biochemistry of protein phosphorylation, a process which appears to be one of the most important mechanisms for the intracellular expression of cyclic nucleotide action in eukaryotic cells.
Editors and Affiliations
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Neuropharmacology Research Laboratory, Departments of Neurology and Pharmacology, Harvard Medical School, Massachusetts General Hospital, Boston, USA
J. A. Nathanson
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Biochemical Neuropharmacology Unit, NINCDS National Institutes of Health, Bethesda, USA
J. W. Kebabian
