Tissue Growth Factors

1. Front Matter

   Pages I-XXII

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2. Introduction to Cell Growth: Growth in Size and DNA Replication

   • R. Baserga

   Pages 1-12

3. Survival and Growth Requirements of Nontransformed Cells

   • R. G. Ham

   Pages 13-88

4. Epidermal Growth Factor

   • G. Carpenter

   Pages 89-132

5. The Platelet-Derived Growth Factor

   • R. Ross

   Pages 133-159

6. Somatomedin: Physiological Control and Effects on Cell Proliferation

   • D. R. Clemmons, J. J. Van Wyk

   Pages 161-208

7. Glucocorticoid Modulation of Cell Proliferation

   • V. J. Cristofalo, B. A. Rosner

   Pages 209-228

8. Proteases as Growth Factors

   • D. D. Cunningham

   Pages 229-248

9. Nerve Growth Factor

   • Mary J. Koroly, M. Young

   Pages 249-276

10. The Role of Cold Insoluble Globulin (Plasma Fibronectin) in Cell Adhesion In Vitro

    • F. Grinnell

    Pages 277-299

11. Membrane-Derived Inhibitory Factors

    • P. Datta

    Pages 301-312

12. Diffusible Factors in Tissue Cultures

    • Louise Harel

    Pages 313-341

13. Hemopoietic Colony Stimulating Factors

    • D. Metcalf

    Pages 343-384

14. Inhibition of Hematopoietic Cell Proliferation

    • J. H. Fitchen, M. J. Cline

    Pages 385-404

15. Inducers and Inhibitors of Leukemic Cell Differentiation in Culture

    • Janet Abrahm, G. Rovera

    Pages 405-425

16. Angiogenesis Factor(s)

    • P. M. Gullino

    Pages 427-449

17. Growth of Human Tumors in Culture

    • Helene S. Smith, Ch. M. Dollbaum

    Pages 451-490

18. The Chalones

    • O. H. Iversen

    Pages 491-550

19. Back Matter

    Pages 551-632

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From a logical point of view, cell division is regulated by the environment and by the ability of the cell to respond to the environmental signals. The terminology of the cell cycle, the elaborate mathematical models, and the kinetic analyses are all convenient notations and descriptions of the behavior of populations of cells. However, they tell us very little about the fundamental molecular mechanisms that control cell proliferation. Stated in other terms, what controls cell reproduction are growth factors in the environment and genes and gene products inside the cell or at its surface. This book examines the aforementioned growth factors, the study of which has made very rapid progress in the past few years. The selection of topics has been influenced by logistic considerations, but the book, as a whole, gives a broad survey of the state of the art of this exciting field. For this, thanks are due to the contributors, who have given much time to the preparation of the manuscripts and have met the deadline with a punctuality that is uncommon among biomedical scientists. I would also like to thank Ms. NORA PERRETT and the staff of Springer-Verlag for their help in editing the manuscripts and in preparing the production of the book.

• Glucocorticoid
• Hormone
• Insulin
• Prostaglandin
• biology
• chemistry
• growth factor
• kidney
• kinetics
• lipide
• metabolism
• morphogenesis
• nutrition
• physiology
• toxicity

• Fels Research Institute and Department of Pathology, Temple University School of Medicine, Health Sciences Center, Philadelphia, USA

  Renato Baserga

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