Further Studies in the Assessment of Toxic Actions

Testing for Mutagenicity and Carcinogenicity

1. Front Matter

   Pages 1-1

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2. Assessment of Mutagenicity Tests

   • G. Röhrborn

   Pages 3-9

3. Testing of Medicines for Their Mutagenic Potency. Proposition from a French Working Party

   • G. Raynaud, D. Marzin

   Pages 10-10

4. Monitoring the Occupational Exposure to Mutagens by the Cytogenetic Analysis of Human Peripheral Lymphocytes in vivo

   • R. J. Šrám, N. P. Kuleshov

   Pages 11-18

5. Elevated Mitotic Number in the Adrenal Cortex as a Reflection of Early Events in Growth Induction by Carcinogens and Promoters — A Possible Short-Term Assay

   • M. Danz, H. Urban

   Pages 19-21

6. Sister Chromatid Exchanges in Chinese Hamster Embryonic Liver Cells Exposed Transplacentally to Bromodeoxyuridine (BrdU) and Chemical Mutagens

   • A. Basler

   Pages 22-24

7. Differences in Carcinogenicity After Transplacental and Postnatal Administration of Drugs and Pesticides

   • R. Warzok, J. Mendel, R. Thust, E.-M. Blaufuss, H. Batka, H. Schwarz

   Pages 25-28

8. Combination Effects in Chemical Carcinogenesis

   • D. Schmähl

   Pages 29-40

9. Chromosome Aberration Tests with Chinese Hamster Cells in vitro with and without Metabolic Activation — A Comparative Study on Mutagens and Carcinogens

   • M. Ishidate Jr., K. Yoshikawa

   Pages 41-44

10. Ligand Binding of Safrole to Cytochrome P-450

    • M. Delaforge, C. Ioannides, D. V. Parke

    Pages 45-48

11. Testing of Drugs for Combined Mutagenesis with Sodium Nitrite in the Host-mediated Assay

    • R. Braun, J. Schöneich, D. Ziebarth

    Pages 49-53

12. Biotransformation and Spectral Interaction of Xenobiotics with Subcellular Fractions from Drosophila Melanogaster

    • A. J. Baars, J. A. Zijlstra, M. Jansen, E. Vogel, D. D. Breimer

    Pages 54-58

13. Mutagenicity of DNOC in Drosophila Melanogaster

    • J. Müller, R. Haberzettl

    Pages 59-61

14. Standardization of Clastogenicity and SCE Assays on Mammalian Cells in vitro — Results and Problems

    • R. Thust, J. Mendel, S. Kneist, R. Warzok

    Pages 62-62

15. Influence of Experimental Factors on the Mutagenicity of Vinylic Monomers

    • F. Poncelet, C. de Meester, M. Duverger-van Bogaert, M. Lambotte-Vandepaer, M. Roberfroid, M. Mercier

    Pages 63-66

16. Modification of Mutagenic Activity of Anticancer Drugs

    • J. Revazova, L. Radchenko, G. Muravnik

    Pages 67-67

17. Mutagenic Activity in Foundry Air

    • E. Skyttä, R. Schimberg, H. Vainio

    Pages 68-72

18. The Effect of Carcinogens and Non-Carcinogens on Some Biochemical Features of the Mouse Lung Tissue

    • I. Arany, P. Rady, F. Boján, P. Kertai

    Pages 73-73

19. Attempt to Develop New Mouse Colony with High Susceptibility to Carcinogens

    • F. Boján, P. Kertai

    Pages 74-76