Progress in Multiple Sclerosis Research

1. Front Matter

   Pages I-XIX

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2. Experimental Models in Demyelinating Disease

   1. Front Matter

      Pages 1-1

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   2. Applications of Chronic Relapsing Experimental Allergic Encephalomyelitis to the Study of Multiple Sclerosis

      • C. S. Raine, U. Traugott, S. H. Stone

      Pages 3-10

   3. Chronic Relapsing EAE: Its Application to Study of Human Inflammatory Demyelinating Diseases

      • H. M. Wisniewski, H. Lassmann

      Pages 11-17

   4. Refinement of the EAE Model Utilizing Various Synthetic Adjuvants and Bacterial Fractions: An Attempt to Produce a Chronic Model of EAE

      • Y. Nagai, K. Akiyama, S. Kotani, T. Shimono, T. Shiba, T. Yamamoto

      Pages 18-27

   5. Discussion

      • H. J. Bauer, S. Poser, G. Ritter

      Pages 28-30

   6. Theiler’s Virus Infection of the Central Nervous System of Mice: An Animal Model of Virus-Induced Demyelination

      • H. L. Lipton, M. C. Dal Canto

      Pages 31-34

   7. Acute and Recurrent Demyelination Induced by Wild-Type and Temperature-Sensitive Mutants of Mouse Hepatitis Virus. Electron-Microscopic Studies

      • P. W. Lampert, M. V. Haspel, M. B. A. Oldstone

      Pages 35-39

   8. Coronavirus Infection in Rats

      • K. Nagashima, H. Wege, R. Meyermann, V. ter Meulen

      Pages 40-46

   9. Search for Viral Nucleic Acids in Multiple Sclerosis Brain

      • K. Dörries, V. ter Meulen

      Pages 47-52

   10. A Possible Coronavirus Isolation from Multiple Sclerosis Autopsy Material

       • J. S. Burks, B. De Vald, L. Jankovsky, J. Gerdes

       Pages 53-58

   11. Defective Viral Infection: The Rescue of Virus from Antigen-Negative Cells

       • S. A. Stohlman, A. Y. Sakaguchi, L. P. Weiner

       Pages 59-62

   12. Some Properties of Cortical Nerve Cells of Adult Rats Bulk Isolated After Brain Perfusion

       • H.-H. Althaus, W. B. Huttner

       Pages 63-66

   13. In Vitro Demyelination by Lymphocytes and Lymphokines from Patients and Experimental Animals

       • T. Yonezawa, N. Arizono, M. Hasegawa, Y. Yamamura, H. Miyaji

       Pages 67-72

   14. The Virus-Host Relationship in CNS Model Cells

       • K. Koschel

       Pages 73-79

   15. Attempts to Transmit Multiple Sclerosis to Newborn and Germ-Free Nonhuman Primates: A Ten Year Interim Report

       • W. A. Sibley, S. S. Kalter, J. F. Laguna

       Pages 80-85

3. Laboratory Investigations in Relation to the Etiology and Pathogenesis of MS

   1. Front Matter

      Pages 87-87

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   2. Introduction

      • H. J. Bauer

      Pages 89-89

   3. Production of Interspecies Hybridomas Between CSF or Blood Lymphocytes from Patients with Neurological Diseases and Mouse Myeloma Cells

      • M. Sandberg-Wollheim, M. Shander, C. M. Croce, H. Koprowski

      Pages 90-97

   4. Antibodies to Myelin Basic Protein in Cerebrospinal Fluid of Patients with Multiple Sclerosis

      • H. S. Panitch, D. A. Hafler, K. P. Johnson

      Pages 98-105

At the annual meetings of the International Federation of Multiple Sclerosis Socie­ ties (IFMSS) the representatives of the national MS societies of numerous countries assemble for discussions and reports on work accomplished, under way, and to be undertaken in the future. In addition to publicity work, education, and patient ser­ vices, there has been an increasing interest in obtaining first hand, reliable, and re­ alistic information not only on the medical problems relevant to diagnosis, treat­ ment, and the management of MS, but also on progress in the difficult field of MS research. For this purpose the International Medical Advisory Board (IMAB) was founded. In the past years its members have organized a number of symposia in conjunc­ tion with the IFMSS meetings in New York, Copenhagen, Barcelona, Toronto, Am­ sterdam. The program of the G6ttingen symposium, relevant in its focus to the 1978 meeting of the IFMSS in Hannover, had the double purpose of bringing together scientists from many countries with active MS societies, and to inform the organi­ zers and members of these societies, and thereby also the MS patients, of problems and progress in a number of areas of MS research. The program was conceived as a survey of newer work undertaken in basic and experimental MS research and, on the clinical side, as a reassessment of the prerequisites in the diagnosis of MS, the value of laboratory tests, some therapeutic approaches, and organizational princi­ ples in the management of MS.

• Laboratory
• Multiple Sklerose
• brain
• diagnosis
• education
• hand
• laboratory tests
• management
• multiple sclerosis
• myelin
• nervous system
• organizations
• patients
• research
• spinal cord

• Neurologische Klinik und Poliklinik, Neues Klinikum, Universität Göttingen, Göttingen, Germany

  H. J. Bauer, S. Poser, G. Ritter

Policies and ethics