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Pharmacology of Ganglionic Transmission

  • Book
  • © 1980

Overview

Editors:
  1. Dimitry A. Kharkevich

    1. Department of Pharmacology, First Medical Institute, Moscow, USSR

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Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 53)

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Table of contents (17 chapters)

  1. Front Matter

    Pages I-XV
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  2. Introduction

    • D. A. Kharkevich
    Pages 1-8

  3. Ganglionic Transmission: Morphology and Physiology

    • V. I. Skok
    Pages 9-39

  4. Ganglionic Metabolism

    • J. D. Klingman, D. T. Organisciak, G. I. Klingman
    Pages 41-61

  5. Methods for the Examination of Ganglion-Blocking Activity

    • L. Gyermek
    Pages 63-121

  6. Relationship Between Chemical Structure and Ganglion-Blocking Activity

    • V. Trčka
    Pages 123-153

  7. Relationship Between Chemical Structure and Ganglion-Blocking Activity

    • V. Trčka
    Pages 155-184

  8. Locus and Mechanism of Action of Ganglion-Blocking Agents

    • D. A. Brown
    Pages 185-235

  9. Action of Ganglion-Blocking Agents on the Cardiovascular System

    • D. M. Aviado
    Pages 237-253

  10. Action of Ganglion-Blocking Agents on the Gastrointestinal Tract

    • D. F. J. Mason
    Pages 255-266

  11. Absorption, Distribution, Fate, and Excretion of Ganglion-Blocking Compounds

    • D. F. J. Mason
    Pages 267-279

  12. Nicotinic Ganglion-Stimulating Agents

    • R. L. Volle
    Pages 281-312

  13. Non-Nicotinic Chemical Stimulation of Automatic Ganglia

    • W. E. Haefely
    Pages 313-357

  14. Ganglion Activity of Centrally Acting Neurotropic Agents

    • A. Nistri, J. P. Quilliam
    Pages 359-384

  15. Ganglionic Actions of Anticholinesterase Agents, Catecholamines, Neuro-Muscular Blocking Agents, and Local Anaesthetics

    • R. L. Volle
    Pages 385-410

  16. Ganglionic Activity of Cardiovascular Drugs

    • D. M. Aviado
    Pages 411-415

  17. Ganglion-Blocking Agents in Internal Medicine

    • E. V. Erina
    Pages 417-438

  18. Ganglion-Blocking Agents in Anaesthesiology

    • A. A. Bunatian, A. V. Meshcherjakov
    Pages 439-463

  19. Back Matter

    Pages 465-534
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Keywords

About this book

D.A. KHARKEVICH The history of the study of ganglionic substances begins with the paper of LANGLEY and DICKINSON (1889), who established the ability of nicotine to block the neurones in the superior cervical ganglion. This was a considerable discovery as the authors ascertained that impulses were transmitted from pre- to postganglionic neurones in the autonomic ganglia. Simultaneously they indicated the possibility of pharmaco­ logical influence upon interneuronal transmission in autonomic ganglia. The idea of ganglionic receptors specifically sensitive to nicotine followed logically. Later, LANGLEY (1905, 1906) considered the problem of receptors with respect to neuro-effector synapses. It is remarkable that he was one of the first to put forward the theory of chemical mediation of excitation (" ... the nervous impulse should not pass from nerve to muscle by an electric discharge, but by the secretion of a special substance at the end of the nerve": LANGLEY, 1906, p. 183). In addition, LANGLEY JOHN N. LANGLEY (1852-1926) D.A. KHARKEVICH 2 and his collaborators managed to define the topography of autonomic ganglia more precisely by means of nicotine. It should be mentioned that it was he who introduced the terms "autonomic nervous system" and "parasympathetic nervous system".

Editors and Affiliations

  • Department of Pharmacology, First Medical Institute, Moscow, USSR

    Dimitry A. Kharkevich

Bibliographic Information

  • Book Title: Pharmacology of Ganglionic Transmission

  • Editors: Dimitry A. Kharkevich

  • Series Title: Handbook of Experimental Pharmacology

  • DOI: https://doi.org/10.1007/978-3-642-67397-9

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1980

  • Softcover ISBN: 978-3-642-67399-3Published: 15 November 2011

  • eBook ISBN: 978-3-642-67397-9Published: 06 December 2012

  • Series ISSN: 0171-2004

  • Series E-ISSN: 1865-0325

  • Edition Number: 1

  • Number of Pages: XVI, 534

  • Topics: Pharmacology/Toxicology, Pharmacy

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