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  • Book
  • © 1979

Current Topics in Microbiology and Immunology

Editors:

  1. W. Arber

    1. Basle, Switzerland

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  2. S. Falkow

    1. Seattle, USA

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  3. W. Henle

    1. Philadelphia, USA

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  4. P. H. Hofschneider

    1. Martinsried, Germany

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  5. J. H. Humphrey

    1. London, UK

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  6. J. Klein

    1. Tübingen, Germany

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  7. P. Koldovský

    1. Düsseldorf, Germany

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  8. H. Koprowski

    1. Basle, Switzerland

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  9. O. Maaløe

    1. Copenhagen, Denmark

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  10. F. Melchers

    1. Basle, Switzerland

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  11. R. Rott

    1. GieBen, The Netherlands

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  12. H. G. Schweiger

    1. Ladenburg/Heidelberg, Germany

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  13. L. Syruĉek

    1. Prague, Czech Republic

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  14. P. K. Vogt

    1. Los Angeles, USA

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Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 85)

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Table of contents (3 chapters)

  1. Front Matter

    Pages i-iii
    PDF

  4. Chemistry and Biology of the Enterobacterial Common Antigen (ECA)

    • Hubert Mayer, Gunter Schmidt
    Pages 99-153

  5. Back Matter

    Pages 155-183
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About this book

The study of the genetic regulation of immune response to natural multidetermi­ nant immunogens was undertaken by the method of bidirectional selective breed­ ing of High or Low antibody responder lines of mice. Five Selections are described: Selection I, carried out for agglutinin responsiveness to sheep erythrocytes and pigeon erythrocytes alternated in each generation. Selection II, carried out for agglutinin responsiveness to sheep erythrocytes repeated in each generation. Selection III and Selection IV performed respectively for agglutinin response to flagellar or somatic antigens of Salmonella typhimurium and Salmonella oranienburg alternated in each generation. Selection V, performed for passive agglutinin response to bovine serum albumin and rabbit gamma globulin alternated in each generation. In each Selection the character investigated is polygenic. High and Low responder lines diverge progressively during the selective breeding. The maximal interline separation (selection limit) is reached in the 7th-16th generations. High and Low responder lines at selection limit are considered homozygous for the character submitted to se~ection. Their variance is therefore only due to environ­ mental effects. The difference in agglutinin titre between High and Low lines is 220-fold in Selection I, 103-fold in Selection II, 90-fold in Selection III, 85-fold in Selection IV and 275-fold in Selection V. The partition of genetic and environmental variances in the foundation popu­ lations of the five Selections is established. The proportion of genetic variance is 60% in Selection I; 49% in Selection II; 51% in Selection III; 47% in Selection IV and 76% in Selection V.
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Keywords

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Editors and Affiliations

  • Basle, Switzerland

    W. Arber, H. Koprowski, F. Melchers

  • Seattle, USA

    S. Falkow

  • Philadelphia, USA

    W. Henle

  • Martinsried, Germany

    P. H. Hofschneider

  • London, UK

    J. H. Humphrey

  • Tübingen, Germany

    J. Klein

  • Düsseldorf, Germany

    P. Koldovský

  • Copenhagen, Denmark

    O. Maaløe

  • GieBen, The Netherlands

    R. Rott

  • Ladenburg/Heidelberg, Germany

    H. G. Schweiger

  • Prague, Czech Republic

    L. Syruĉek

  • Los Angeles, USA

    P. K. Vogt

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Bibliographic Information

  • Book Title: Current Topics in Microbiology and Immunology

  • Editors: W. Arber, S. Falkow, W. Henle, P. H. Hofschneider, J. H. Humphrey, J. Klein, P. Koldovský, H. Koprowski, O. Maaløe, F. Melchers, R. Rott, H. G. Schweiger, L. Syruĉek, … P. K. Vogt

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-67322-1

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 1979

  • Softcover ISBN: 978-3-642-67324-5Published: 15 November 2011

  • eBook ISBN: 978-3-642-67322-1Published: 06 December 2012

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: IV, 184

  • Topics: Medicine/Public Health, general, Biomedicine general, Life Sciences, general

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Buy it now

eBook USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

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