Bradykinin, Kallidin and Kallikrein

1. Front Matter

   Pages I-XXII

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2. The Plasma Kallikrein-Kinin System and Its Interrelationship With Other Components of Blood

   • H. Z. Movat

   Pages 1-89

3. Kininogenases of Blood Cells (Alternate Kinin Generating Systems)

   • L. M. Greenbaum

   Pages 91-102

4. Enzymology of Glandular Kallikreins

   • F. Fiedler

   Pages 103-161

5. Kallikrein Inhibitors

   • R. Vogel

   Pages 163-225

6. Chemistry and Biologic Activity of Peptides Related to Bradykinin

   • J. M. Stewart

   Pages 227-272

7. Kinins in Nature

   • J. J. Pisano

   Pages 273-285

8. Bradykinin Receptors

   • C. E. Odya, T. L. Goodfriend

   Pages 287-300

9. Bradykinin Radioimmunoassay

   • R. C. Talamo, T. L. Goodfriend

   Pages 301-309

10. Kinins and the Peripheral and Central Nervous Systems

    • W. G. Clark

    Pages 311-356

11. Effects of Kinins on Organ Systems

    • A. R. Johnson

    Pages 357-399

12. Release of Vasoactive Substances by Kinins

    • N. A. Terragno, A. Terragno

    Pages 401-426

13. Kininases

    • E. G. Erdös

    Pages 427-487

14. Kallikrein in Exocrine Glands

    • K. Bhoola, M. Lemon, R. Matthews

    Pages 489-523

15. Renal and Urinary Kallikreins

    • P. E. Ward, H. S. Margolius

    Pages 525-548

16. Renal Kallikrein and Regulation of Blood Pressure in Man

    • I. H. Mills

    Pages 549-567

17. Kallikrein-Kinin System in Pathologic Conditions

    • R. W. Colman, P. Y. Wong

    Pages 569-607

18. Bradykinin, Kallidin, and Kallikreins

    • T. S. Paskhina, A. P. Levitsky

    Pages 609-656

19. Back Matter

    Pages 657-820

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Volume XXV of the Handbook of Experimental Pharmacology series entitled "Bradykinin, Kallidin, and Kallikrein" was published in 1970. My aim in editing this volume of the series is not to replace, but to update the 1970 edition. During the decade preceding the publication of Vol. XXV, the existence of kinins and kallikreins gained acceptance, the protein components of the system were purified and characterized and the peptides were synthesized. Even after these accomplish­ ments, interest in the subject has not abated, but has increased substantially. We have learned a great deal about the role that components of the kallikrein-kinin system play in other systems and about the immensely complex and intricate inter­ actions in blood. Directly or indirectly, kallikrein and kinins affect the coagulation of blood, the activation of complement, and the generation of angiotensin. Kinins release or modulate the actions of other agents, including prostaglandins, histamine, and catecholamines. Inhibitors of kallikrein or kininase II are employed, for example, in extracorporeal circulation or in hypertension. Kallikrein, kinins, and kininases, present in urine, were described first in 1925 and 1954, but have been ignored for decades. These substances are now studied extensively because of their possible role in blood pressure regulation. The evidence that kinins have a metabolic function is also increasing. The abundance of active components of the system in genital organs suggests a role in the fertilization process. The book is organized into chapters which bear upon these issues.

• Bradykinin
• Histamin
• Kallidin
• Kallikrein
• Prostaglandin
• blood
• central nervous system
• chemistry
• circulation
• hypertension
• nervous system
• peptides
• pharmacology
• protein
• regulation

• Departments of Pharmacology, and Internal Medicine, The University of Texas, Southwestern Medical School, Dallas, USA

  Ervin G. Erdös

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