Etomidate

1. Front Matter

   Pages I-XI

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2. The Experimental Pharmacology of Etomidate, a New Potent, Short-Acting Intravenous Hypnotic

   • R. S. Reneman, P. A. J. Janssen

   Pages 1-5

3. Protein Binding of Etomidate

   • G. A. Mannes, A. Doenicke

   Pages 6-8

4. The Effect of Intra-Arterial Injection of Etomidate and Thiopental on the Skeletal Muscle- and Arterial Wall-Structures

   • R. S. Reneman, F. Verheyen, R. Kruger, W. van Gerven, M. Borges

   Pages 9-14

5. Interaction between Etomidate and the Antihypertensive Agents Propranolol and ∝-Methyl-Dopa

   • R. S. Reneman, W. Van Gerven, R. Kruger

   Pages 15-22

6. Teratogenicity of Etomidate

   • A. Doenicke, M. Haehl

   Pages 23-24

7. Etomidate, a New Hypnotic Agent for Intravenous Application

   • A. Doenicke

   Pages 25-30

8. The EEG after Etomidate

   • J. Kugler, A. Doenicke, M. Laub

   Pages 31-48

9. A Comparison of the Acute Effects of Intravenous Induction Agents (Thiopentone, Methohexitone, Propanidid, Althesin, Ketamine, Piritramide and Etomidate) on Haemodynamics and Myocardial Oxygen Consumption in Dogs

   • D. Patschke, J. B. Brückner, J. W. Gethmann, J. Tarnow, A. Weymar

   Pages 49-71

10. Haemodynamic Effects of Etomidate — a New Hypnotic — in Patients with Myocardial Insufficiency

    • G. Hempelmann, W. Oster, S. Piepenbrock, G. Karliczek

    Pages 72-80

11. Haemodynamics, Myocardial Function, Oxygen Requirement, and Oxygen Supply of the Human Heart after Administration of Etomidate

    • D. Kettler, H. Sonntag, U. Wolfram-Donath, H. J. Hoeft, D. Regensburger, H. D. Schenk

    Pages 81-94

12. Experimental Investigations on the Direct Effect of Etomidate on Myocardial Contractility

    • K.-J. Fischer, H. Marquort

    Pages 95-112

13. The Influence of R 26 490 (Etomidate Sulfate) on Ventilation and Gas Exchange

    • B. Marquardt, H. Waibel, J. B. Brückner

    Pages 113-118

14. A Comparative Study of Blood Gases and Haemodynamics Using the New Hypnotic Etomidate, CT 1341, Methohexitone, Propanidid, and Thiopentone

    • W. Hempelmann, G. Hempelmann, S. Piepenbrock

    Pages 119-129

15. The Use of Etomidate as an Induction Agent in Fentanyl Analgesia

    • Z. Kalenda

    Pages 130-139

16. Etomidate Anaesthesia for Cardioversion

    • A. Weymar, D. Patschke, J. Tarnow, J. B. Brückner

    Pages 140-143

17. Etomidate and Fentanyl for Emergency Anaesthesia in Acute Bleeding with Haemorrhagic Shock

    • M. Zindler

    Pages 144-145

18. Clinical Experience with Etomidate in Diagnostical Interventions and Operations of Short Duration

    • A. Doenicke, W. Spiess, B. Grote, J. Aranoji

    Pages 146-151

19. Etomidate as “A New Drug in Intravenous Anaesthesia” (Conclusion)

    • A. Doenicke

    Pages 152-155

20. Back Matter

    Pages 157-158

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The question how to induce general anaesthesia without problems has been asked repeatedly by anaesthetists and pharmacologists. P. A. JANSSEN developed etomidate and published this substance in 1971 as "a potent short-acting and relatively atoxic intravenous hypnotic agent in rats". In 1974 after several years of experimental and clinical trial the barbiturate-free hypnotic etomidate (soon marketed as Hypnomidate) was introduced to numerous auditors at the occasion of the IV. European Congress of Anaesthesiologists in Madrid. As the authors extended their essays, the actuality of the present book is given. The conclusion mentions the new solution of etomidate base in 35 % propylene glycol. It is expected that the disadvantageous effects - venous pain during injection and associated involuntary muscle movement- will largely be eliminated by using the new formula of etomidate after premedication of fentanyl. Mlinchen, August 1977 Alfred DOENICKE TABLE OF CONTENTS The Experimental Pharmacology of Etomidate, a New Potent, Short-Acting Intravenous Hypnotic (R. S. RENEMAN and P. A. JANSSEN) •. . . . •• 1 Protein Binding of Etomidate (G. A. MANNES and A. DOENICKE) ••••. . . 6 The Effect of Intra-Arterial Injection of Etomidate and Thiopental on the Skeletal Muscle- and Arterial Wall-Structures (R. S. RENEMAN, F. VERHEYEN, R. KRUGER, W. VAN GERVEN and M. BORGES) . . •. . •• 9 Interaction between Etomidate and the Antihypertensive Agents Propanolol andoC-Methyl-Dopa (R. S. RENEMAN, W. VAN GERVEN and R. KRUGER) ••. •. . . 15 Teratogenicity of Etomidate (A. DOENICKE and M. HAEHL) •. ••. •.

• Etomidat
• clinical trial
• drug
• pain
• research
• shock

• Anaesthesie-Abteilung, Chirurgische Poliklinik der Universität, München 2, Deutschland

  A. Doenicke

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