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Heme and Hemoproteins

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  • © 1978
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Overview

Editors:
  1. Francesco Matteis

    1. Medical Research Council Labs., MRC Toxicology Unit, Carshalton, Surrey, Great Britain

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  2. W. Norman Aldridge

    1. Medical Research Council Labs., MRC Toxicology Unit, Carshalton, Surrey, Great Britain

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 44)

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Table of contents (11 chapters)

  1. Front Matter

    Pages I-XVII
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  2. The Biosynthesis and Degradation of Heme

    • George H. Tait
    Pages 1-48
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  3. Induction of Hepatic Hemoproteins

    • K. W. Bock, H. Remmer
    Pages 49-80
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  4. Inhibition of Liver Hemoprotein Synthesis

    • Thomas R. Tephly
    Pages 81-94
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  5. Loss of Liver Cytochrome P-450 Caused by Chemicals

    • F. De Matteis
    Pages 95-127
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  6. Hepatic Porphyrias

    • F. De Matteis
    Pages 129-155
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  7. Porphyria Caused by Hexachlorobenzene and Other Polyhalogenated Aromatic Hydrocarbons

    • G. H. Elder
    Pages 157-200
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  8. The Effect of Chemicals on Hepatic Heme Biosynthesis

    • Gerald S. Marks
    Pages 201-237
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  9. Pharmacogenetics in the Field of Heme Metabolism: Drug Sensitivity in Hereditary Hepatic Porphyria

    • J. Douglas Maxwell, Urs A. Meyer
    Pages 239-254
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  10. The Influence of Hormonal and Nutritional Factors on the Regulation of Liver Heme Biosynthesis

    • D. P. Tschudy
    Pages 255-271
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  11. Effects of Drugs on Bilirubin Metabolism

    • H. L. Rayner, B. A. Schacter, L. G. Israels
    Pages 273-332
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  12. Toxic Effects of Lead, with Particular Reference to Porphyrin and Heme Metabolism

    • Shigeru Sassa
    Pages 333-371
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  13. Back Matter

    Pages 373-452
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Keywords

About this book

The study of the biological effects of foreign chemicals (whether therapeutic drugs or chemicals present at work or in the environment) interests the biologist from a number of different and complementary viewpoints. Apart from the more obvious pharmacological and toxicological interest, the experimentalist often uses foreign chemicals to produce in experimental animals disease states similar to naturally occurring diseases, so that their pathogenetic mechanisms and therapy can be studied under controlled conditions. In addition - as Claude Bernard pointed out over a century ago - foreign chemicals can be employed as instruments to analyze the most delicate vital processes; much can be learned about the physiological processes themselves by a careful study of the mechanisms by which these are altered by chemicals. The field of heme and hemoproteins offers an example of the interplay of these different approaches. Their metabolism can be altered by therapeutic drugs and other foreign chemicals and this results in a variety of biological responses that transcend the boundaries of pharmacology into the confines of clinical medi­ cine, genetics, toxicology, biochemistry and physiology. In this book a multidisciplinary approach to the study of heme metabolism is presented including the effect of chemicals on heme metabolism in patients, the results of experimental work in the whole animal, as well as in vitro studies.

Editors and Affiliations

  • Medical Research Council Labs., MRC Toxicology Unit, Carshalton, Surrey, Great Britain

    Francesco Matteis, W. Norman Aldridge

Bibliographic Information

  • Book Title: Heme and Hemoproteins

  • Editors: Francesco Matteis, W. Norman Aldridge

  • Series Title: Handbook of Experimental Pharmacology

  • DOI: https://doi.org/10.1007/978-3-642-66763-3

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1978

  • Softcover ISBN: 978-3-642-66765-7Published: 18 October 2011

  • eBook ISBN: 978-3-642-66763-3Published: 06 December 2012

  • Series ISSN: 0171-2004

  • Series E-ISSN: 1865-0325

  • Edition Number: 1

  • Number of Pages: XVIII, 452

  • Topics: Medicine/Public Health, general, Pharmacy

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