Drug Addiction I

1. Front Matter

   Pages I-XXIII

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2. Problems of Drug Dependence

   1. Front Matter

      Pages 1-1

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   2. General Problems of Drug Abuse and Drug Dependence

      • W. R. Martin

      Pages 3-40

3. Morphine Dependence

   1. Front Matter

      Pages 41-41

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   2. Neuropharmacology and Neurochemistry of Subjective Effects, Analgesia, Tolerance, and Dependence Produced by Narcotic Analgesics

      • W. R. Martin, J. W. Sloan

      Pages 43-158

   3. Assessment of the Abuse Potential of Narcotic Analgesics in Animals

      • W. R. Martin, D. R. Jasinski

      Pages 159-196

   4. Assessment of the Abuse Potentiality of Morphinelike Drugs (Methods Used in Man)

      • D. R. Jasinski

      Pages 197-258

   5. Psychiatric Treatment of Narcotic Addiction

      • H. T. Conrad

      Pages 259-278

   6. Chemotherapy of Narcotic Addiction

      • W. R. Martin

      Pages 279-318

   7. Detection of Drugs of Abuse in Biological Fluids

      • Ch. W. Gorodetzky

      Pages 319-409

4. Sedative/Hypnotics and Alcohol Dependence

   1. Front Matter

      Pages 411-411

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   2. The Pharmacology of Sedative/Hypnotics, Alcohol, and Anesthetics: Sites and Mechanisms of Action

      • Cedric M. Smith

      Pages 413-587

   3. The Assessment of the Abuse Potentiality of Sedative/Hypnotics (Depressants) (Methods Used in Animals and Man)

      • H. F. Fraser, D. R. Jasinski

      Pages 589-612

   4. Clinical Aspects of Alcohol Dependence

      • N. K. Mello, J. H. Mendelson

      Pages 613-666

   5. Abuse of Non-Narcotic Analgesics

      • P. Kielholz, D. Ladewig

      Pages 667-672

5. Back Matter

   Pages 673-750

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This volume addresses the general problem of drug addiction from several points of view, which are in some ways quite unique and different from other areas of pharmacology. Drug addiction is closely associated with criminal behavior. One of the great and noble edifices of civilization is the philosophic and ethical view that man is perfectible, and some believe that this can be achieved by providing the appropriate circumstance or environment in which man can mature and be educated. Some have postulated that drug abuse is a consequence of an inadequate or pathologic set of socializing experiences or is a consequence of basic conflicts between the values and accepted patterns of behavior of a subculture and that of a larger culture. The degree to which man is malleable and perfectible by social forces is not known nor do we know the true desirability of socializing individuals to the extent that their behavior does not deviate from social norms. Some deviancy is essential for innovation and creativity, and at times there may be difficulties in determining whether an innovator or creator is exhibiting sociopathic behavior or not. This aspect of drug addiction is inherently a matter of social values and ethics.

• drug
• drug abuse
• ethics
• pharmacology
• research

• Department of Health, Education, and Welfare, Public Health Service, National Institute on Drug Abuse, Addiction Research Center, Lexington, USA

  William R. Martin

Policies and ethics