Developmental Biology and Pathology

1. Front Matter

   Pages I-IX

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2. Introduction

   1. Front Matter

      Pages 1-1

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   2. Developmental Anomalies Arising from Errors of Fertilization and Cleavage

      • C. R. Austin

      Pages 3-6

3. Oocyte, Early Embryo and Maternal Host. Morphology and Biochemistry

   1. Front Matter

      Pages 7-7

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   2. Oocyte Maturation and Paternal Contribution to the Embryo in Mammals

      • D. Szöllösi

      Pages 9-27

   3. Maternal Storage in the Mammalian Oocyte

      • W. Engel, W. Franke

      Pages 29-52

   4. The Genetic Activity of Early Mammalian Embryos

      • Ch. J. Epstein

      Pages 53-58

   5. Formation of the Blastocyst: Determination of Trophoblast and Embryonic Knot

      • H.-W. Denker

      Pages 59-79

4. Pharmacological and Hormonal Influences in Early Embryogenesis

   1. Front Matter

      Pages 81-81

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   2. The Response of the Preimplantation Embryo to Exogenous Factors

      • Cecilia Lutwak-Mann

      Pages 83-86

   3. Embryo Transfer Technique and Action of Drugs on the Preimplantation Embryo

      • H. Spielmann

      Pages 87-103

   4. Uterine Secretion Protein Patterns Under Hormonal Influences

      • H. M. Beier

      Pages 105-120

5. Teratology

   1. Front Matter

      Pages 121-121

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   2. Organ Culture in Teratology

      • L. Saxén, M. Karkinen-Jääskeläinen, I. Saxén

      Pages 123-143

   3. Teratogenic Effects and Placental Permeability of Heavy Metals

      • V. H. Ferm

      Pages 145-151

6. Cytogenetics

   1. Front Matter

      Pages 153-153

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   2. Experimental Heteroploidy in Mammals

      • O. Bomsel-Helmreich

      Pages 155-175

   3. Autosomal Monosomy and Trisomy Causing Developmental Failure

      • A. Gropp, B. Putz, U. Zimmermann

      Pages 177-192

   4. Chromosomal Anomalies in Early Spontaneous Abortion

      • J. G. Boué, A. Boué

      Pages 193-208

7. Back Matter

   Pages 209-218

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The early development of the mammalian embryo belongs to a period which, for the student, provides the particularly deep fascination connected with the processes of germination of the fIrst tender buds of life. Moreover, developmental biology encompasses a very large part of biology; if broadly dermed - almost all of it. The same is true for the fIeld of pathology if the manifold possibilities of disorders of the orderly arranged pathways of developmental processes are considered. Normal development in its earliest steps - and it would be diffI­ cult to see it otherwise - means the functioning of very intricate systems of complex inter­ dependent cycles controlled by structural, genetic, physiological and biochemical determi­ nants. However, disturbances interfering with them in their very different ways, can lead to fetal death, disorders of growth and differentiation, malformation and disease, sometimes as late as in the next generation or later. This is, indeed, the concern of the pathologist to whom and to whose interest in developmental pathology, this book is dedicated. The outlines of the present volume were conceived at a symposium on "Control of early em­ bryogenesis and factors responsible for failure of embryonic development" held May 1-4, 1974 in Travemtinde and sponsored by the Deutsche Forschungsgemeinschaft. Almost fIfty active participants attended this conference. At the time and in keeping with the purpose of the conference, publication of the proceedings was not envisaged.

• Embryopathie
• Säugetiere
• biology
• development
• developmental biology
• embryo
• mammals

• Abteilung für Pathologie, Medizinische Hochschule Lübeck, Lübeck, Germany

  A. Gropp

• Department of Obstetrics and Gynecology, San Diego School of Medicine, La Jolla, USA

  K. Benirschke

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